Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-κB-Activating Factors through Direct Downregulation of IKKα a...

por Hancock, Meaghan H., Hook, Lauren M., Mitchell, Jennifer, Nelson, Jay A.
Publicado 2017

A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model

por Awasthi, Sita, Hook, Lauren M., Shaw, Carolyn E., Friedman, Harvey M.
Publicado 2017

Herpes simplex virus type 2 trivalent protein vaccine containing glycoproteins C, D and E protects guinea pigs against HSV-1 genital infection

por Egan, Kevin, Hook, Lauren M., Naughton, Alexis, Friedman, Harvey M., Awasthi, Sita
Publicado 2020

An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs

por Awasthi, Sita, Hook, Lauren M., Shaw, Carolyn E., Pahar, Bapi, Stagray, Jacob A., Liu, David, Veazey, Ronald S., Friedman, Harvey M.
Publicado 2017

An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection

por Egan, Kevin P., Hook, Lauren M., Naughton, Alexis, Pardi, Norbert, Awasthi, Sita, Cohen, Gary H., Weissman, Drew, Friedman, Harvey M.
Publicado 2020

Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guin...

por Hook, Lauren M., Cairns, Tina M., Awasthi, Sita, Brooks, Benjamin D., Ditto, Noah T., Eisenberg, Roselyn J., Cohen, Gary H., Friedman, Harvey M.
Publicado 2018

A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same...

por Egan, Kevin P., Awasthi, Sita, Tebaldi, Giulia, Hook, Lauren M., Naughton, Alexis M., Fowler, Bernard T., Beattie, Mitchell, Alameh, Mohamad-Gabriel, Weissman, Drew, Cohen, Gary H., Friedman, Harvey M.
Publicado 2023

Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine

por Hook, Lauren M., Awasthi, Sita, Cairns, Tina M., Alameh, Mohamad-Gabriel, Fowler, Bernard T., Egan, Kevin P., Sung, Molly M. H., Weissman, Drew, Cohen, Gary H., Friedman, Harvey M.
Publicado 2022

Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine i...

por Awasthi, Sita, Onishi, Motoyasu, Lubinski, John M., Fowler, Bernard T., Naughton, Alexis M., Hook, Lauren M., Egan, Kevin P., Hagiwara, Masaki, Shirai, Seiki, Sakai, Akiho, Nakagawa, Takayuki, Goto, Kumiko, Yoshida, Osamu, Stephens, Alisa J., Choi, Grace, Cohen, Gary H., Katayama, Kazufumi, Friedman, Harvey M.
Publicado 2023