Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice

por Schafer, Peter H., Adams, Mary, Horan, Gerald, Truzzi, Francesca, Marconi, Alessandra, Pincelli, Carlo
Publicado 2019

CC-90001, a c-Jun N-terminal kinase (JNK) inhibitor, in patients with pulmonary fibrosis: design of a phase 2, randomised, placebo-controlled trial

por Popmihajlov, Zoran, Sutherland, Donna J, Horan, Gerald S, Ghosh, Atalanta, Lynch, David A, Noble, Paul W, Richeldi, Luca, Reiss, Theodore F, Greenberg, Steven
Publicado 2022

Safety, Pharmacokinetics, and Pharmacodynamics of CC‐90001 (BMS‐986360), a c‐Jun N‐terminal Kinase Inhibitor, in Phase 1 Studies in Healthy Participants

por Ye, Ying, Gaudy, Allison, Thomas, Michael, Reyes, Josephine, Burkhardt, Barbara, Horan, Gerald, Liu, Liangang, Chen, Jian, Ghosh, Atalanta, Carayannopoulos, Leonidas N., Tatosian, Daniel A., Palmisano, Maria
Publicado 2022

CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production

por Gaur, Rajula, Mensah, Kofi A., Stricker, Jason, Adams, Mary, Parton, Anastasia, Cedzik, Dorota, Connarn, Jamie, Thomas, Michael, Horan, Gerald, Schafer, Peter, Mair, Stuart, Palmisano, Maria, Ramírez-Valle, Francisco
Publicado 2022

JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers

por van der Velden, Jos L. J., Ye, Ying, Nolin, James D., Hoffman, Sidra M., Chapman, David G., Lahue, Karolyn G., Abdalla, Sarah, Chen, Peng, Liu, Yong, Bennett, Brydon, Khalil, Nasreen, Sutherland, Donna, Smith, William, Horan, Gerald, Assaf, Mahmoud, Horowitz, Zebulun, Chopra, Rajesh, Stevens, Randall M., Palmisano, Maria, Janssen-Heininger, Yvonne M. W., Schafer, Peter H.
Publicado 2016