Rho Family GTPases and Rho GEFs in Glucose Homeostasis

por Machin, Polly A., Tsonou, Elpida, Hornigold, David C., Welch, Heidi C. E.
Publicado 2021

A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice

por Hornigold, David C., Roth, Emma, Howard, Victor, Will, Sarah, Oldham, Stephanie, Coghlan, Matthew P., Blouet, Clemence, Trevaskis, James L.
Publicado 2018

P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cells

por Hampson, Elizabeth, Tsonou, Elpida, Baker, Martin J., Hornigold, David C., Hubbard, Roderick E., Massey, Andrew, Welch, Heidi C. E.
Publicado 2021

Self-assembled GLP-1/glucagon peptide nanofibrils prolong inhibition of food intake

por Ouberai, Myriam M., Gomes Dos Santos, Ana L., Kinna, Sonja, Hornigold, David C., Baker, David, Naylor, Jacqueline, Liang, Lihuan, Corkill, Dominic J., Welland, Mark E.
Publicado 2023

Development and characterisation of a novel glucagon like peptide-1 receptor antibody

por Biggs, Emma K., Liang, Lihuan, Naylor, Jacqueline, Madalli, Shimona, Collier, Rachel, Coghlan, Matthew P., Baker, David J., Hornigold, David C., Ravn, Peter, Reimann, Frank, Gribble, Fiona M.
Publicado 2017

The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells

por Johansen, Valdemar B. I., Hampson, Elizabeth, Tsonou, Elpida, Pantarelli, Chiara, Chu, Julia Y., Crossland, Laraine, Okkenhaug, Hanneke, Massey, Andrew J., Hornigold, David C., Welch, Heidi C. E., Chetwynd, Stephen A.
Publicado 2023

A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation

por Marshall, Jason D., Heeke, Darren S., Rao, Eileen, Maynard, Sean K., Hornigold, David, McCrae, Christopher, Fraser, Neil, Tovchigrechko, Andrey, Yu, Li, Williams, Nicola, King, Sarah, Cooper, Martin E., Hajjar, Adeline M., Woo, Jennifer C.
Publicado 2016

Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly

por Ouberai, Myriam M., Dos Santos, Ana L. Gomes, Kinna, Sonja, Madalli, Shimona, Hornigold, David C., Baker, David, Naylor, Jacqueline, Sheldrake, Laura, Corkill, Dominic J., Hood, John, Vicini, Paolo, Uddin, Shahid, Bishop, Steven, Varley, Paul G., Welland, Mark E.
Publicado 2017

Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery

por Larraufie, Pierre, Roberts, Geoffrey P., McGavigan, Anne K., Kay, Richard G., Li, Joyce, Leiter, Andrew, Melvin, Audrey, Biggs, Emma K., Ravn, Peter, Davy, Kathleen, Hornigold, David C., Yeo, Giles S.H., Hardwick, Richard H., Reimann, Frank, Gribble, Fiona M.
Publicado 2019

Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice

por Lewis, Jo E., Woodward, Orla RM., Nuzzaci, Danaé, Smith, Christopher A., Adriaenssens, Alice E., Billing, Lawrence, Brighton, Cheryl, Phillips, Benjamin U., Tadross, John A., Kinston, Sarah J., Ciabatti, Ernesto, Göttgens, Berthold, Tripodi, Marco, Hornigold, David, Baker, David, Gribble, Fiona M., Reimann, Frank
Publicado 2022

Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment

por Chodorge, Matthieu, Celeste, Anthony J., Grimsby, Joseph, Konkar, Anish, Davidsson, Pia, Fairman, David, Jenkinson, Lesley, Naylor, Jacqueline, White, Nicholas, Seaman, Jonathan C., Dickson, Karen, Kemp, Benjamin, Spooner, Jennifer, Rossy, Emmanuel, Hornigold, David C., Trevaskis, James L., Bond, Nicholas J., London, Timothy B., Buchanan, Andrew, Vaughan, Tristan, Rondinone, Cristina M., Osbourn, Jane K.
Publicado 2018

Peptide-YY(3-36)/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergis...

por Boland, Brandon B., Laker, Rhianna C., O'Brien, Siobhan, Sitaula, Sadichha, Sermadiras, Isabelle, Nielsen, Jens Christian, Barkholt, Pernille, Roostalu, Urmas, Hecksher-Sørensen, Jacob, Sejthen, Sara Rubek, Thorbek, Ditte Dencker, Suckow, Arthur, Burmeister, Nicole, Oldham, Stephanie, Will, Sarah, Howard, Victor G., Gill, Benji M., Newton, Philip, Naylor, Jacqueline, Hornigold, David C., Austin, Jotham, Lantier, Louise, McGuinness, Owen P., Trevaskis, James L., Grimsby, Joseph S., Rhodes, Christopher J.
Publicado 2021