Structural and Functional Consequences of Circular Permutation on the Active Site of Old Yellow Enzyme

por Daugherty, Ashley B., Horton, John R., Cheng, Xiaodong, Lutz, Stefan
Publicado 2014

Structures of Escherichia coli DNA adenine methyltransferase (Dam) in complex with a non-GATC sequence: potential implications for methylation-independent transcriptional repressio...

por Horton, John R., Zhang, Xing, Blumenthal, Robert M., Cheng, Xiaodong
Publicado 2015

Structural basis for human PRDM9 action at recombination hot spots

por Patel, Anamika, Horton, John R., Wilson, Geoffrey G., Zhang, Xing, Cheng, Xiaodong
Publicado 2016

Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix

por Zhou, Jujun, Horton, John R., Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong
Publicado 2021

Beta class amino methyltransferases from bacteria to humans: evolution and structural consequences

por Woodcock, Clayton B, Horton, John R, Zhang, Xing, Blumenthal, Robert M, Cheng, Xiaodong
Publicado 2020

A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2

por Horton, John R., Zhou, Jujun, Chen, Qin, Zhang, Xing, Bedford, Mark T., Cheng, Xiaodong
Publicado 2022

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling

por Chang, Yanqi, Levy, Dan, Horton, John R., Peng, Junmin, Zhang, Xing, Gozani, Or, Cheng, Xiaodong
Publicado 2011

Role for first zinc finger of WT1 in DNA sequence specificity: Denys–Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites

por Wang, Dongxue, Horton, John R, Zheng, Yu, Blumenthal, Robert M, Zhang, Xing, Cheng, Xiaodong
Publicado 2018

Structure of HinP1I endonuclease reveals a striking similarity to the monomeric restriction enzyme MspI

por Yang, Zhe, Horton, John R., Maunus, Robert, Wilson, Geoffrey G., Roberts, Richard J., Cheng, Xiaodong
Publicado 2005

The State of Infectious Diseases Clinical Trials: A Systematic Review of ClinicalTrials.gov

por Goswami, Neela D., Pfeiffer, Christopher D., Horton, John R., Chiswell, Karen, Tasneem, Asba, Tsalik, Ephraim L.
Publicado 2013

Structural basis for the target specificity of actin histidine methyltransferase SETD3

por Dai, Shaobo, Horton, John R., Woodcock, Clayton B., Wilkinson, Alex W., Zhang, Xing, Gozani, Or, Cheng, Xiaodong
Publicado 2019

The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site

por Horton, John R., Woodcock, Clayton B., Opot, Sifa B., Reich, Norbert O., Zhang, Xing, Cheng, Xiaodong
Publicado 2019

Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine

por Yang, Jie, Horton, John R, Li, Jia, Huang, Yun, Zhang, Xing, Blumenthal, Robert M, Cheng, Xiaodong
Publicado 2019

Metabolic and cardiorespiratory effects of decreasing lung hyperinflation with budesonide/formoterol in COPD: a randomized, double-crossover, placebo-controlled, multicenter trial

por Divo, Miguel J., DePietro, Michael R., Horton, John R., Maguire, Cherie A., Celli, Bartolome R.
Publicado 2020

Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA

por Zhou, Jujun, Horton, John R., Yu, Dan, Ren, Ren, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong
Publicado 2021

Structures of CTCF–DNA complexes including all 11 zinc fingers

por Yang, Jie, Horton, John R, Liu, Bin, Corces, Victor G, Blumenthal, Robert M, Zhang, Xing, Cheng, Xiaodong
Publicado 2023

DNA nicking by HinP1I endonuclease: bending, base flipping and minor groove expansion

por Horton, John R., Zhang, Xing, Maunus, Robert, Yang, Zhe, Wilson, Geoffrey G., Roberts, Richard J., Cheng, Xiaodong
Publicado 2006

Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta

por Hong, Samuel, Wang, Dongxue, Horton, John R., Zhang, Xing, Speck, Samuel H., Blumenthal, Robert M., Cheng, Xiaodong
Publicado 2017

Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA

por Woodcock, Clayton B, Horton, John R, Zhou, Jujun, Bedford, Mark T, Blumenthal, Robert M, Zhang, Xing, Cheng, Xiaodong
Publicado 2020

Structure of HhaI endonuclease with cognate DNA at an atomic resolution of 1.0 Å

por Horton, John R, Yang, Jie, Zhang, Xing, Petronzio, Theresa, Fomenkov, Alexey, Wilson, Geoffrey G, Roberts, Richard J, Cheng, Xiaodong
Publicado 2020