Evaluating steroid hormone receptor interactions using the live-cell NanoBRET proximity assay

por Huggins, Rosemary J, Hosfield, David, Ishag-Osman, Amira, Lee, Keemin, Ton-That, Elia, Greene, Geoffrey L.
Publicado 2023

Overcoming mutation-based resistance to antiandrogens with rational drug design

por Balbas, Minna D, Evans, Michael J, Hosfield, David J, Wongvipat, John, Arora, Vivek K, Watson, Philip A, Chen, Yu, Greene, Geoffrey L, Shen, Yang, Sawyers, Charles L
Publicado 2013

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells

por Hosfield, David J, Weber, Sandra, Li, Nan-Sheng, Sauvage, Madline, Joiner, Carstyn F, Hancock, Govinda R, Sullivan, Emily A, Ndukwe, Estelle, Han, Ross, Cush, Sydney, Lainé, Muriel, Mader, Sylvie C, Greene, Geoffrey L, Fanning, Sean W
Publicado 2022

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

por Fanning, Sean W, Jeselsohn, Rinath, Dharmarajan, Venkatasubramanian, Mayne, Christopher G, Karimi, Mostafa, Buchwalter, Gilles, Houtman, René, Toy, Weiyi, Fowler, Colin E, Han, Ross, Lainé, Muriel, Carlson, Kathryn E, Martin, Teresa A, Nowak, Jason, Nwachukwu, Jerome C, Hosfield, David J, Chandarlapaty, Sarat, Tajkhorshid, Emad, Nettles, Kendall W, Griffin, Patrick R, Shen, Yang, Katzenellenbogen, John A, Brown, Myles, Greene, Geoffrey L
Publicado 2018