Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics

por Sun, Yuanzi, Jack, Kezia, Ercolani, Tiziana, Sangar, Daljit, Hosszu, Laszlo, Collinge, John, Bieschke, Jan
Publicado 2023

High-affinity tamoxifen analogues retain extensive positional disorder when bound to calmodulin

por Milanesi, Lilia, Trevitt, Clare R., Whitehead, Brian, Hounslow, Andrea M., Tomas, Salvador, Hosszu, Laszlo L. P., Hunter, Christopher A., Waltho, Jonathan P.
Publicado 2021

A novel prion protein variant in a patient with semantic dementia

por Kenny, Joanna, Woollacott, Ione, Koriath, Carolin, Hosszu, Laszlo, Adamson, Gary, Rudge, Peter, Rossor, Martin N, Collinge, John, Rohrer, Jonathan D, Mead, Simon
Publicado 2017

Ex vivo mammalian prions are formed of paired double helical prion protein fibrils

por Terry, Cassandra, Wenborn, Adam, Gros, Nathalie, Sells, Jessica, Joiner, Susan, Hosszu, Laszlo L. P., Tattum, M. Howard, Panico, Silvia, Clare, Daniel K., Collinge, John, Saibil, Helen R., Wadsworth, Jonathan D. F.
Publicado 2016

Characterization of Prion Disease Associated with a Two-Octapeptide Repeat Insertion

por Brennecke, Nicholas, Cali, Ignazio, Mok, Tze How, Speedy, Helen, Hosszu, Laszlo L. P., Stehmann, Christiane, Cracco, Laura, Puoti, Gianfranco, Prior, Thomas W., Cohen, Mark L., Collins, Steven J., Mead, Simon, Appleby, Brian S.
Publicado 2021

Evaluating the causality of novel sequence variants in the prion protein gene by example

por Mok, Tze How, Koriath, Carolin, Jaunmuktane, Zane, Campbell, Tracy, Joiner, Susan, Wadsworth, Jonathan D.F., Hosszu, Laszlo L.P., Brandner, Sebastian, Parvez, Ambereen, Truelsen, Thomas Clement, Lund, Eva Løbner, Saha, Romi, Collinge, John, Mead, Simon
Publicado 2018

Structural effects of the highly protective V127 polymorphism on human prion protein

por Hosszu, Laszlo L. P., Conners, Rebecca, Sangar, Daljit, Batchelor, Mark, Sawyer, Elizabeth B., Fisher, Stuart, Cliff, Matthew J., Hounslow, Andrea M., McAuley, Katherine, Leo Brady, R., Jackson, Graham S., Bieschke, Jan, Waltho, Jonathan P., Collinge, John
Publicado 2020

N-terminal Domain of Prion Protein Directs Its Oligomeric Association

por Trevitt, Clare R., Hosszu, Laszlo L. P., Batchelor, Mark, Panico, Silvia, Terry, Cassandra, Nicoll, Andrew J., Risse, Emmanuel, Taylor, William A., Sandberg, Malin K., Al-Doujaily, Huda, Linehan, Jacqueline M., Saibil, Helen R., Scott, David J., Collinge, John, Waltho, Jonathan P., Clarke, Anthony R.
Publicado 2014

A systematic investigation of production of synthetic prions from recombinant prion protein

por Schmidt, Christian, Fizet, Jeremie, Properzi, Francesca, Batchelor, Mark, Sandberg, Malin K., Edgeworth, Julie A., Afran, Louise, Ho, Sammy, Badhan, Anjna, Klier, Steffi, Linehan, Jacqueline M., Brandner, Sebastian, Hosszu, Laszlo L. P., Tattum, M. Howard, Jat, Parmjit, Clarke, Anthony R., Klöhn, Peter C., Wadsworth, Jonathan D. F., Jackson, Graham S., Collinge, John
Publicado 2015