A subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinoma

por Houchen, Courtney W., Li, Min
Publicado 2020

Epigenetic Landscape and Therapeutic Implication of Gene Isoforms of Doublecortin-Like Kinase 1 for Cancer Stem Cells

por Moore, Landon L., Houchen, Courtney W.
Publicado 2023

Attenuating DNA damage response and immunosuppression radiosensitizes pancreatic cancer

por Zhang, Yuqing, Houchen, Courtney W., Li, Min
Publicado 2022

Cancer Stem Cell Marker DCLK1 Correlates with Tumorigenic Immune Infiltrates in the Colon and Gastric Adenocarcinoma Microenvironments

por Wu, Xiangyan, Qu, Dongfeng, Weygant, Nathaniel, Peng, Jun, Houchen, Courtney W.
Publicado 2020

Tuft and Cancer Stem Cell Marker DCLK1: A New Target to Enhance Anti-Tumor Immunity in the Tumor Microenvironment

por Cao, Zhiyun, Weygant, Nathaniel, Chandrakesan, Parthasarathy, Houchen, Courtney W., Peng, Jun, Qu, Dongfeng
Publicado 2020

Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP

por Mondalek, Fadee G, Ponnurangam, Sivapriya, Govind, Janita, Houchen, Courtney, Anant, Shrikant, Pantazis, Panayotis, Ramanujam, Rama P
Publicado 2010

Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism

por Panneerselvam, Janani, Madka, Venkateshwar, Rai, Rajani, Morris, Katherine T., Houchen, Courtney W., Chandrakesan, Parthasarathy, Rao, Chinthalapally V.
Publicado 2021

Novel Regenerative Peptide TP508 Mitigates Radiation-Induced Gastrointestinal Damage By Activating Stem Cells and Preserving Crypt Integrity

por Kantara, Carla, Moya, Stephanie M., Houchen, Courtney W., Umar, Shahid, Ullrich, Robert L., Singh, Pomila, Carney, Darrell H.
Publicado 2015

Elevated doublecortin-like kinase 1 serum levels revert to baseline after therapy in early stage esophageal adenocarcinoma

por Christman, Emily M., Chandrakesan, Parthasarathy, Weygant, Nathaniel, Maple, John T., Tierney, William M., Vega, Kenneth J., Houchen, Courtney W.
Publicado 2019

RNA Binding Protein CUGBP2/CELF2 Mediates Curcumin-Induced Mitotic Catastrophe of Pancreatic Cancer Cells

por Subramaniam, Dharmalingam, Ramalingam, Satish, Linehan, David C., Dieckgraefe, Brian K., Postier, Russell G., Houchen, Courtney W., Jensen, Roy A., Anant, Shrikant
Publicado 2011

Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism

por Sureban, Sripathi M, May, Randal, Mondalek, Fadee G, Qu, Dongfeng, Ponnurangam, Sivapriya, Pantazis, Panayotis, Anant, Shrikant, Ramanujam, Rama P, Houchen, Courtney W
Publicado 2011

Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis

por Qu, Dongfeng, Weygant, Nathaniel, May, Randal, Chandrakesan, Parthasarathy, Madhoun, Mohammad, Ali, Naushad, Sureban, Sripathi M., An, Guangyu, Schlosser, Michael J., Houchen, Courtney W.
Publicado 2015

Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases

por Yarla, Nagendra Sastri, Pathuri, Gopal, Gali, Hariprasad, Terzyan, Simon, Panneerselvam, Janani, Chandrakesan, Parthasarathy, Scotti, Marcus Tullius, Houchen, Courtney, Madka, Venkateshwar, Rao, Chinthalapally V
Publicado 2020

Toxicity Assessment of Mesoporous Silica Nanoparticles upon Intravenous Injection in Mice: Implications for Drug Delivery

por MacCuaig, William M., Samykutty, Abhilash, Foote, Jeremy, Luo, Wenyi, Filatenkov, Alexander, Li, Min, Houchen, Courtney, Grizzle, William E., McNally, Lacey R.
Publicado 2022

Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2–AKT–TGF-β Signaling Axis in Pancreatic Cancer

por Shi, Xiuhui, Yang, Jingxuan, Liu, Mingyang, Zhang, Yuqing, Zhou, Zhijun, Luo, Wenyi, Fung, Kar-Ming, Xu, Chao, Bronze, Michael S., Houchen, Courtney W., Li, Min
Publicado 2022

Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1

por Weygant, Nathaniel, Qu, Dongfeng, Berry, William L, May, Randal, Chandrakesan, Parthasarathy, Owen, Daniel B, Sureban, Sripathi M, Ali, Naushad, Janknecht, Ralf, Houchen, Courtney W
Publicado 2014

Dclk1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition

por Chandrakesan, Parthasarathy, Weygant, Nathaniel, May, Randal, Qu, Dongfeng, Chinthalapally, Harisha R., Sureban, Sripathi M., Ali, Naushad, Lightfoot, Stan A., Umar, Shahid, Houchen, Courtney W.
Publicado 2014

Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury

por Chandrakesan, Parthasarathy, May, Randal, Weygant, Nathaniel, Qu, Dongfeng, Berry, William L., Sureban, Sripathi M., Ali, Naushad, Rao, Chinthalapally, Huycke, Mark, Bronze, Michael S., Houchen, Courtney W.
Publicado 2016

DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers

por Sureban, Sripathi M., Berahovich, Robert, Zhou, Hua, Xu, Shirley, Wu, Lijun, Ding, Kai, May, Randal, Qu, Dongfeng, Bannerman-Menson, Edwin, Golubovskaya, Vita, Houchen, Courtney W.
Publicado 2019

Dietary Pectin Increases Intestinal Crypt Stem Cell Survival following Radiation Injury

por Sureban, Sripathi M., May, Randal, Qu, Dongfeng, Chandrakesan, Parthasarathy, Weygant, Nathaniel, Ali, Naushad, Lightfoot, Stan A., Ding, Kai, Umar, Shahid, Schlosser, Michael J., Houchen, Courtney W.
Publicado 2015