A large scale classification of molecular fingerprints for the chemical space representation and SAR analysis

por López-Vallejo, Fabian, Waddell, Jacob, Yongye, Austin B, Houghten, Richard A, Medina-Franco, José L
Publicado 2012

Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT)

por Dong, Hui, Madegowda, Mahendra, Nefzi, Adel, Houghten, Richard A., Giulianotti, Marc A., Rosen, Barry P.
Publicado 2015

Activity-difference maps and consensus similarity measure characterize structure-activity relationships

por Medina-Franco, José L, Yongye, Austin B, Pérez-Villanueva, Jaime, Houghten, Richard A, Martínez-Mayorga, Karina
Publicado 2012

Identification of a Small Molecule That Selectively Inhibits Mouse PC2 over Mouse PC1/3: A Computational and Experimental Study

por Yongye, Austin B., Vivoli, Mirella, Lindberg, Iris, Appel, Jon R., Houghten, Richard A., Martinez-Mayorga, Karina
Publicado 2013

Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide

por Li, Yangmei, Eans, Shainnel O., Ganno-Sherwood, Michelle, Eliasof, Abbe, Houghten, Richard A., McLaughlin, Jay P.
Publicado 2023

The Mathematics of a Successful Deconvolution: A Quantitative Assessment of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors

por Santos, Radleigh G., Appel, Jon R., Giulianotti, Marc A., Edwards, Bruce S., Sklar, Larry A., Houghten, Richard A., Pinilla, Clemencia
Publicado 2013

A Novel Probe for Spliceosomal Proteins that Induces Autophagy and Death of Melanoma Cells Reveals New Targets for Melanoma Drug Discovery

por Palrasu, Manikandan, Knapinska, Anna M., Diez, Juan, Smith, Lyndsay, LaVoi, Travis, Giulianotti, Marc, Houghten, Richard A., Fields, Gregg B., Minond, Dmitriy
Publicado 2019

Discovery of a Potent and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist from an α-Conotoxin Synthetic Combinatorial Library

por Chang, Yi-Pin, Banerjee, Jayati, Dowell, Cheryl, Wu, Jinhua, Gyanda, Reena, Houghten, Richard A., Toll, Lawrence, McIntosh, J. Michael, Armishaw, Christopher J.
Publicado 2014

Novel Pyrrolidine Diketopiperazines Selectively Inhibit Melanoma Cells via Induction of Late-Onset Apoptosis

por Onwuha-Ekpete, Lillian, Tack, Lisa, Knapinska, Anna, Smith, Lyndsay, Kaushik, Gaurav, LaVoi, Travis, Giulianotti, Marc, Houghten, Richard A., Fields, Gregg B., Minond, Dmitriy
Publicado 2014

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens

por Fleeman, Renee M., Debevec, Ginamarie, Antonen, Kirsten, Adams, Jessie L., Santos, Radleigh G., Welmaker, Gregory S., Houghten, Richard A., Giulianotti, Marc A., Shaw, Lindsey N.
Publicado 2018

The Parallel Structure–Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (M...

por Ericson, Mark D., Freeman, Katie T., LaVoi, Travis M., Donow, Haley M., Santos, Radleigh G., Giulianotti, Marc A., Pinilla, Clemencia, Houghten, Richard A., Haskell-Luevano, Carrie
Publicado 2023

Degeneracy of Antigen Recognition as the Molecular Basis for the High Frequency of Naive A2/Melan-A Peptide Multimer(+) CD8(+) T Cells in Humans

por Dutoit, Valérie, Rubio-Godoy, Verena, Pittet, Mikäel J., Zippelius, Alfred, Dietrich, Pierre-Yves, Legal, Frédérique Anne, Guillaume, Philippe, Romero, Pedro, Cerottini, Jean-Charles, Houghten, Richard A., Pinilla, Clemencia, Valmori, Danila
Publicado 2002

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines

por Houghten, Richard A., Ganno, Michelle L., McLaughlin, Jay P., Dooley, Colette T., Eans, Shainnel O., Santos, Radleigh G., LaVoi, Travis, Nefzi, Adel, Welmaker, Greg, Giulianotti, Marc A., Toll, Lawrence
Publicado 2015

Novel Cyclic Lipopeptides Fusaricidin Analogs for Treating Wound Infections

por Gil, Joel, Pastar, Irena, Houghten, Richard A., Padhee, Shruti, Higa, Alexander, Solis, Michael, Valdez, Jose, Head, Cheyanne R., Michaels, Heather, Lenhart, Brian, Simms, Colin, Williams, Brandon, Cudic, Predrag, Davis, Stephen C.
Publicado 2021

The Multi-Leu Peptide Inhibitor Discriminates Between PACE4 and Furin And Exhibits Antiproliferative Effects On Prostate Cancer Cells

por Levesque, Christine, Fugère, Martin, Kwiatkowska, Anna, Couture, Frédéric, Desjardins, Roxane, Routhier, Sophie, Moussette, Philippe, Prahl, Adam, Lammek, Bernard, Appel, Jon R., Houghten, Richard A., D’Anjou, François, Dory, Yves L., Neugebauer, Witold, Day, Robert
Publicado 2012

Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human...

por Haslach, Erica M., Huang, Huisuo, Dirain, Marvin, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh G., Giulianotti, Marc A., Pinilla, Clemencia, Appel, Jon R., Doering, Skye R., Walters, Michael A., Houghten, Richard A., Haskell-Luevano, Carrie
Publicado 2014

Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis

por Welsh, Kate, Milutinovic, Snezana, Ardecky, Robert J., Gonzalez-Lopez, Marcos, Ganji, Santhi Reddy, Teriete, Peter, Finlay, Darren, Riedl, Stefan, Matsuzawa, Shu-ichi, Pinilla, Clemencia, Houghten, Richard, Vuori, Kristiina, Reed, John C., Cosford, Nicholas D. P.
Publicado 2016