Flavonoids as Human Intestinal α-Glucosidase Inhibitors

por Barber, Elizabeth, Houghton, Michael J., Williamson, Gary
Publicado 2021

Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8(+) T Cell Responses to Chronic Viral Infections and Cancer

por Okoye, Isobel S., Houghton, Michael, Tyrrell, Lorne, Barakat, Khaled, Elahi, Shokrollah
Publicado 2017

Modeling the human Na(v)1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade

por Ahmed, Marawan, Jalily Hasani, Horia, Ganesan, Aravindhan, Houghton, Michael, Barakat, Khaled
Publicado 2017

The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections

por Egli, Adrian, Santer, Deanna M, O'Shea, Daire, Tyrrell, D Lorne, Houghton, Michael
Publicado 2014

Progress towards a hepatitis C virus vaccine

por Man John Law, Lok, Landi, Abdolamir, Magee, Wendy C, Lorne Tyrrell, D, Houghton, Michael
Publicado 2013

Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism

por Sarhan, Mohammed A., Abdel-Hakeem, Mohamed S., Mason, Andrew L., Tyrrell, D. Lorne, Houghton, Michael
Publicado 2017

Enhanced Activation of Memory, but Not Naïve, B Cells in Chronic Hepatitis C Virus-Infected Patients with Cryoglobulinemia and Advanced Liver Fibrosis

por Santer, Deanna M., Ma, Mang M., Hockman, Darren, Landi, Abdolamir, Tyrrell, D. Lorne J., Houghton, Michael
Publicado 2013

A structure-based computational workflow to predict liability and binding modes of small molecules to hERG

por Kalyaanamoorthy, Subha, Lamothe, Shawn M., Hou, Xiaoqing, Moon, Tae Chul, Kurata, Harley T., Houghton, Michael, Barakat, Khaled H.
Publicado 2020

Memory CD8(+) T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection

por Shoukry, Naglaa H., Grakoui, Arash, Houghton, Michael, Chien, David Y., Ghrayeb, John, Reimann, Keith A., Walker, Christopher M.
Publicado 2003

Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19

por Aminpour, Maral, Delgado, Williams Ernesto Miranda, Wacker, Soren, Noskov, Sergey, Houghton, Michael, Tyrrell, D. Lorne J., Tuszynski, Jack A.
Publicado 2021

Characterization of antibodies induced by vaccination with Hepatitis C virus envelope glycoproteins

por Ray, Ranjit, Meyer, Keith, Banerjee, Arup, Basu, Arnab, Coates, Stephen, Abrignani, Sergio, Houghton, Michael, Frey, Sharon E., Belshe, Robert B.
Publicado 2010

Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells

por Santer, Deanna M., Minty, Gillian E. S., Golec, Dominic P., Lu, Julia, May, Julia, Namdar, Afshin, Shah, Juhi, Elahi, Shokrollah, Proud, David, Joyce, Michael, Tyrrell, D. Lorne, Houghton, Michael
Publicado 2020

Prospective Comparison of Ankle Replacement and Ankle Arthrodesis 4 Years After Surgery

por Satngeorzan, Bruce J., Norvell, Daniel, Ledoux, William R., Coetzee, J. Chris, Davitt, James S., Shofer, Jane, Anderson, John G., Bohay, Donald R., Houghton, Michael J., Maskill, John D., Brage, Michael E.
Publicado 2020

Role of the E2 Hypervariable Region (HVR1) in the Immunogenicity of a Recombinant Hepatitis C Virus Vaccine

por Law, John L. M., Logan, Michael, Wong, Jason, Kundu, Juthika, Hockman, Darren, Landi, Amir, Chen, Chao, Crawford, Kevin, Wininger, Mark, Johnson, Janelle, Mesa Prince, Catalina, Dudek, Elzbieta, Mehta, Ninad, Tyrrell, D. Lorne, Houghton, Michael
Publicado 2018

A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of...

por Johnson, Janelle, Freedman, Holly, Logan, Michael, Wong, Jason Alexander Ji-Xhin, Hockman, Darren, Chen, Chao, He, Jianqi, Beard, Michael R., Eyre, Nicholas S., Baumert, Thomas F., Tyrrell, D. Lorne, Law, John L. M., Houghton, Michael
Publicado 2019

A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in Humans

por Law, John Lok Man, Chen, Chao, Wong, Jason, Hockman, Darren, Santer, Deanna M., Frey, Sharon E., Belshe, Robert B., Wakita, Takaji, Bukh, Jens, Jones, Christopher T., Rice, Charles M., Abrignani, Sergio, Tyrrell, D. Lorne, Houghton, Michael
Publicado 2013

Effect of Different Adjuvants on the Longevity and Strength of Humoral and Cellular Immune Responses to the HCV Envelope Glycoproteins

por Akache, Bassel, Deschatelets, Lise, Harrison, Blair A., Dudani, Renu, Stark, Felicity C., Jia, Yimei, Landi, Amir, Law, John L. M., Logan, Michael, Hockman, Darren, Kundu, Juthika, Tyrrell, D. Lorne, Krishnan, Lakshmi, Houghton, Michael, McCluskie, Michael J.
Publicado 2019

No Evidence for XMRV Nucleic Acids, Infectious Virus or Anti-XMRV Antibodies in Canadian Patients with Chronic Fatigue Syndrome

por Steffen, Imke, Tyrrell, D. Lorne, Stein, Eleanor, Montalvo, Leilani, Lee, Tzong-Hae, Zhou, Yanchen, Lu, Kai, Switzer, William M., Tang, Shaohua, Jia, Hongwei, Hockman, Darren, Santer, Deanna M., Logan, Michael, Landi, Amir, Law, John, Houghton, Michael, Simmons, Graham
Publicado 2011

A Fibrosis‐Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis

por Gindin, Yevgeniy, Chung, Chuhan, Jiang, Zhaoshi, Zhou, Jing Zhu, Xu, Jun, Billin, Andrew N., Myers, Robert P., Goodman, Zachary, Landi, Abdolamir, Houghton, Michael, Green, Richard M., Levy, Cynthia, Kowdley, Kris V., Bowlus, Christopher L., Muir, Andrew J., Trauner, Michael
Publicado 2021

IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza

por Egli, Adrian, Santer, Deanna M., O'Shea, Daire, Barakat, Khaled, Syedbasha, Mohammedyaseen, Vollmer, Madeleine, Baluch, Aliyah, Bhat, Rakesh, Groenendyk, Jody, Joyce, Michael A., Lisboa, Luiz F., Thomas, Brad S., Battegay, Manuel, Khanna, Nina, Mueller, Thomas, Tyrrell, D. Lorne J., Houghton, Michael, Humar, Atul, Kumar, Deepali
Publicado 2014