A Model of Glucocorticoid Receptor Interaction With Coregulators Predicts Transcriptional Regulation of Target Genes

por Monczor, Federico, Chatzopoulou, Antonia, Zappia, Carlos Daniel, Houtman, René, Meijer, Onno C., Fitzsimons, Carlos P.
Publicado 2019

SUN-LB001 Estetrol (E4) Is a Unique Estrogen with Selective Actions in Tissues Which Are Distinctly Different from the Actions of SERMs

por Foidart, Jean-Michel, Arnal, Jean-Francois, Lenfant, Françoise, Taziaux, Mélanie, Houtman, René, Jost, Maud, Lobo, Roger
Publicado 2019

The Hippocampal Response to Acute Corticosterone Elevation Is Altered in a Mouse Model for Angelman Syndrome

por Viho, Eva M. G., Punt, A. Mattijs, Distel, Ben, Houtman, René, Kroon, Jan, Elgersma, Ype, Meijer, Onno C.
Publicado 2022

Co-activator candidate interactions for orphan nuclear receptor NR2E1

por Corso-Díaz, Ximena, de Leeuw, Charles N., Alonso, Vivian, Melchers, Diana, Wong, Bibiana K. Y., Houtman, René, Simpson, Elizabeth M.
Publicado 2016

Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies

por Clarisse, Dorien, Thommis, Jonathan, Van Wesemael, Karlien, Houtman, René, Ratman, Dariusz, Tavernier, Jan, Offner, Fritz, Beck, Ilse, De Bosscher, Karolien
Publicado 2017

Differential in Vitro Biological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand–ER [Formula: see text] Complexes

por Li, Yin, Perera, Lalith, Coons, Laurel A., Burns, Katherine A., Tyler Ramsey, J., Pelch, Katherine E., Houtman, René, van Beuningen, Rinie, Teng, Christina T., Korach, Kenneth S.
Publicado 2018

Peripheral glucocorticoid receptor antagonism by relacorilant with modest HPA axis disinhibition

por Viho, Eva M G, Kroon, Jan, Feelders, Richard A, Houtman, René, van den Dungen, Elisabeth S R, Pereira, Alberto M, Hunt, Hazel J, Hofland, Leo J, Meijer, Onno C
Publicado 2022

The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity

por Koorneef, Lisa L, Kroon, Jan, Viho, Eva M G, Wahl, Lucas F, Heckmans, Kim M L, van Dorst, Marloes M A R, Hoekstra, Menno, Houtman, René, Hunt, Hazel, Meijer, Onno C
Publicado 2020

OR12-07 Full Antagonism of Breast Cancer Cell Proliferation Can Result from Many Ligand-Induced Conformational Distortions of the Estrogen Receptor Ligand Binding Domain

por Nwachukwu, Jerome, Min, Jian, Srinivasan, Sathish K, Rangarajan, Erumbi, Guillen, Valeria Sanabria, Ziegler, Yvonne, Carlson, Kathryn, Hou, Yingwei, Kim, Sung Hoon, Izard, Tina, Houtman, Rene, Katzenellenbogen, Benita S, Nettles, Kendall W, Katzenellenbogen, John A
Publicado 2020

The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors

por Chantalat, Elodie, Boudou, Frédéric, Laurell, Henrik, Palierne, Gaëlle, Houtman, René, Melchers, Diana, Rochaix, Philippe, Filleron, Thomas, Stella, Alexandre, Burlet-Schiltz, Odile, Brouchet, Anne, Flouriot, Gilles, Métivier, Raphaël, Arnal, Jean-François, Fontaine, Coralie, Lenfant, Françoise
Publicado 2016

Estetrol Combined to Progestogen for Menopause or Contraception Indication Is Neutral on Breast Cancer

por Gallez, Anne, Blacher, Silvia, Maquoi, Erik, Konradowski, Erika, Joiret, Marc, Primac, Irina, Gérard, Céline, Taziaux, Mélanie, Houtman, René, Geris, Liesbet, Lenfant, Françoise, Marangoni, Elisabetta, Sounni, Nor Eddine, Foidart, Jean-Michel, Noël, Agnès, Péqueux, Christel
Publicado 2021

ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models

por Guo, Shanchun, Zhang, Changde, Bratton, Melyssa, Mottamal, Madhusoodanan, Liu, Jiawang, Ma, Peng, Zheng, Shilong, Zhong, Qiu, Yang, Lin, Wiese, Thomas E., Wu, Yong, Ellis, Matthew J., Matossian, Margarite, Burow, Matthew E., Miele, Lucio, Houtman, René, Wang, Guangdi
Publicado 2018

Predictive features of ligand‐specific signaling through the estrogen receptor

por Nwachukwu, Jerome C, Srinivasan, Sathish, Zheng, Yangfan, Wang, Song, Min, Jian, Dong, Chune, Liao, Zongquan, Nowak, Jason, Wright, Nicholas J, Houtman, René, Carlson, Kathryn E, Josan, Jatinder S, Elemento, Olivier, Katzenellenbogen, John A, Zhou, Hai‐Bing, Nettles, Kendall W
Publicado 2016

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

por Nwachukwu, Jerome C, Srinivasan, Sathish, Bruno, Nelson E, Parent, Alexander A, Hughes, Travis S, Pollock, Julie A, Gjyshi, Olsi, Cavett, Valerie, Nowak, Jason, Garcia-Ordonez, Ruben D, Houtman, René, Griffin, Patrick R, Kojetin, Douglas J, Katzenellenbogen, John A, Conkright, Michael D, Nettles, Kendall W
Publicado 2014

Natural helix 9 mutants of PPARγ differently affect its transcriptional activity

por Broekema, Marjoleine F., Massink, Maarten P.G., Donato, Cinzia, de Ligt, Joep, Schaarschmidt, Joerg, Borgman, Anouska, Schooneman, Marieke G., Melchers, Diana, Gerding, Martin N., Houtman, René, Bonvin, Alexandre M.J.J., Majithia, Amit R., Monajemi, Houshang, van Haaften, Gijs W., Soeters, Maarten R., Kalkhoven, Eric
Publicado 2018

Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads

por Chirumamilla, Chandra S., Palagani, Ajay, Kamaraj, Balu, Declerck, Ken, Verbeek, Marinus W. C., Oksana, Ryabtsova, De Bosscher, Karolien, Bougarne, Nadia, Ruttens, Bart, Gevaert, Kris, Houtman, René, De Vos, Winnok H., Joossens, Jurgen, Van Der Veken, Pieter, Augustyns, Koen, Van Ostade, Xaveer, Bogaerts, Annemie, De Winter, Hans, Vanden Berghe, Wim
Publicado 2017

Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice

por Bell, Rachel M.B., Villalobos, Elisa, Nixon, Mark, Miguelez-Crespo, Allende, Murphy, Lee, Fawkes, Angie, Coutts, Audrey, Sharp, Matthew G.F., Koerner, Martha V., Allan, Emma, Meijer, Onno C., Houtman, Renè, Odermatt, Alex, Beck, Katharina R., Denham, Scott G., Lee, Patricia, Homer, Natalie Z.M., Walker, Brian R., Morgan, Ruth A.
Publicado 2021

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

por Fanning, Sean W, Jeselsohn, Rinath, Dharmarajan, Venkatasubramanian, Mayne, Christopher G, Karimi, Mostafa, Buchwalter, Gilles, Houtman, René, Toy, Weiyi, Fowler, Colin E, Han, Ross, Lainé, Muriel, Carlson, Kathryn E, Martin, Teresa A, Nowak, Jason, Nwachukwu, Jerome C, Hosfield, David J, Chandarlapaty, Sarat, Tajkhorshid, Emad, Nettles, Kendall W, Griffin, Patrick R, Shen, Yang, Katzenellenbogen, John A, Brown, Myles, Greene, Geoffrey L
Publicado 2018

Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity

por Morgan, Ruth A., Beck, Katharina R., Nixon, Mark, Homer, Natalie Z. M., Crawford, Andrew A., Melchers, Diana, Houtman, René, Meijer, Onno C., Stomby, Andreas, Anderson, Anna J., Upreti, Rita, Stimson, Roland H., Olsson, Tommy, Michoel, Tom, Cohain, Ariella, Ruusalepp, Arno, Schadt, Eric E., Björkegren, Johan L. M., Andrew, Ruth, Kenyon, Christopher J., Hadoke, Patrick W. F., Odermatt, Alex, Keen, John A., Walker, Brian R.
Publicado 2017