GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

por Hauge, Maria, Vestmar, Marie A., Husted, Anna S., Ekberg, Jeppe P., Wright, Michael J., Di Salvo, Jerry, Weinglass, Adam B., Engelstoft, Maja S., Madsen, Andreas N., Lückmann, Michael, Miller, Michael W., Trujillo, Maria E., Frimurer, Thomas M., Holst, Birgitte, Howard, Andrew D., Schwartz, Thue W.
Publicado 2014

Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice

por Tan, Carina P., Feng, Yue, Zhou, Yun-Ping, Eiermann, George J., Petrov, Aleksandr, Zhou, Changyou, Lin, Songnian, Salituro, Gino, Meinke, Peter, Mosley, Ralph, Akiyama, Taro E., Einstein, Monica, Kumar, Sanjeev, Berger, Joel P., Mills, Sander G., Thornberry, Nancy A., Yang, Lihu, Howard, Andrew D.
Publicado 2008

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

por Rudenko, Olga, Shang, Jin, Munk, Alexander, Ekberg, Jeppe P., Petersen, Natalia, Engelstoft, Maja S., Egerod, Kristoffer L., Hjorth, Siv A., Wu, Margaret, Feng, Yue, Zhou, Yun-Ping, Mokrosinski, Jacek, Thams, Peter, Reimann, Frank, Gribble, Fiona, Rehfeld, Jens F., Holst, Jens J., Treebak, Jonas T., Howard, Andrew D., Schwartz, Thue W.
Publicado 2018

GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent

por Pachanski, Michele J., Kirkland, Melissa E., Kosinski, Daniel T., Mane, Joel, Cheewatrakoolpong, Boonlert, Xue, Jiyan, Szeto, Daphne, Forrest, Gail, Miller, Corin, Bunzel, Michelle, Plummer, Christopher W., Chobanian, Harry R., Miller, Michael W., Souza, Sarah, Thomas-Fowlkes, Brande S., Ogawa, Aimie M., Weinglass, Adam B., Di Salvo, Jerry, Li, Xiaoyan, Feng, Yue, Tatosian, Daniel A., Howard, Andrew D., Colletti, Steven L., Trujillo, Maria E.
Publicado 2017

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

por Shah, Shrenik K., He, Shuwen, Guo, Liangqin, Truong, Quang, Qi, Hongbo, Du, Wu, Lai, Zhong, Liu, Jian, Jian, Tianying, Hong, Qingmei, Dobbelaar, Peter, Ye, Zhixiong, Sherer, Edward, Feng, Zhe, Yu, Yang, Wong, Frederick, Samuel, Koppara, Madiera, Maria, Karanam, Bindhu V., Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Feng, Yue, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Eiermann, George J., Li, Cai, Pachanski, Michele, Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Morissette, Pierre, Volksdorf, Sylvia, Kerr, Janet, Zhang, Bei B., Howard, Andrew D., Zhou, Yun-Ping, Pasternak, Alexander, Nargund, Ravi P., Hagmann, William K.
Publicado 2015