Interaction of Gcn4 with target gene chromatin is modulated by proteasome function

por Howard, Gregory C., Tansey, William P.
Publicado 2016

Inhibition of MYC by the SMARCB1 tumor suppressor

por Weissmiller, April M., Wang, Jing, Lorey, Shelly L., Howard, Gregory C., Martinez, Ernest, Liu, Qi, Tansey, William P.
Publicado 2019

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B

por Bonizec, Mélanie, Hérissant, Lucas, Pokrzywa, Wojciech, Geng, Fuqiang, Wenzel, Sabine, Howard, Gregory C., Rodriguez, Paco, Krause, Sabine, Tansey, William P., Hoppe, Thorsten, Dargemont, Catherine
Publicado 2014

WIN site inhibition disrupts a subset of WDR5 function

por Siladi, Andrew J., Wang, Jing, Florian, Andrea C., Thomas, Lance R., Creighton, Joy H., Matlock, Brittany K., Flaherty, David K., Lorey, Shelly L., Howard, Gregory C., Fesik, Stephen W., Weissmiller, April M., Liu, Qi, Tansey, William P.
Publicado 2022

WDR5 is a conserved regulator of protein synthesis gene expression

por Bryan, Audra F, Wang, Jing, Howard, Gregory C, Guarnaccia, Alissa D, Woodley, Chase M, Aho, Erin R, Rellinger, Eric J, Matlock, Brittany K, Flaherty, David K, Lorey, Shelly L, Chung, Dai H, Fesik, Stephen W, Liu, Qi, Weissmiller, April M, Tansey, William P
Publicado 2020

Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells

por Florian, Andrea C, Woodley, Chase M, Wang, Jing, Grieb, Brian C, Slota, Macey J, Guerrazzi, Kiana, Hsu, Chih-Yuan, Matlock, Brittany K, Flaherty, David K, Lorey, Shelly L, Fesik, Stephen W, Howard, Gregory C, Liu, Qi, Weissmiller, April M, Tansey, William P
Publicado 2022

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

por Howard, Gregory C., Wang, Jing, Rose, Kristie Lindsey, Patel, Purvi, Tsui, Tina, Florian, Andrea C., Lorey, Shelly L., Grieb, Brian C., Smith, Brianna N., Slota, Macey J., Reynolds, Elizabeth M., Goswami, Soumita, Savona, Michael R., Lee, Taekyu, Fesik, Stephen W., Liu, Qi, Tansey, William P.
Publicado 2023

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

por Teuscher, Kevin B., Chowdhury, Somenath, Meyers, Kenneth M., Tian, Jianhua, Sai, Jiqing, Van Meveren, Mayme, South, Taylor M., Sensintaffar, John L., Rietz, Tyson A., Goswami, Soumita, Wang, Jing, Grieb, Brian C., Lorey, Shelly L., Howard, Gregory C., Liu, Qi, Moore, William J., Stott, Gordon M., Tansey, William P., Lee, Taekyu, Fesik, Stephen W.
Publicado 2022

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

por Aho, Erin R., Wang, Jing, Gogliotti, Rocco D., Howard, Gregory C., Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D., Cheng, Ken, Lorey, Shelly L., Lu, Bin, Wenzel, Sabine, Foshage, Audra M., Alvarado, Joseph, Wang, Feng, Shaw, J. Grace, Zhao, Bin, Weissmiller, April M., Thomas, Lance R., Vakoc, Christopher R., Hall, Matthew D., Hiebert, Scott W., Liu, Qi, Stauffer, Shaun R., Fesik, Stephen W., Tansey, William P.
Publicado 2019