An α–π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb

por Choudhury, Koushik, Howard, Rebecca J., Delemotte, Lucie
Publicado 2022

An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine

por Choudhury, Koushik, Kasimova, Marina A., McComas, Sarah, Howard, Rebecca J., Delemotte, Lucie
Publicado 2022

Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators

por Zhuang, Yuxuan, Noviello, Colleen M., Hibbs, Ryan E., Howard, Rebecca J., Lindahl, Erik
Publicado 2022

Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel

por Lycksell, Marie, Rovšnik, Urška, Hanke, Anton, Martel, Anne, Howard, Rebecca J., Lindahl, Erik
Publicado 2022

Structural and dynamic mechanisms of GABA(A) receptor modulators with opposing activities

por Zhu, Shaotong, Sridhar, Akshay, Teng, Jinfeng, Howard, Rebecca J., Lindahl, Erik, Hibbs, Ryan E.
Publicado 2022

Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity

por Heusser, Stephanie A., Lycksell, Marie, Wang, Xueqing, McComas, Sarah E., Howard, Rebecca J., Lindahl, Erik
Publicado 2018

Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations

por Rovšnik, Urška, Zhuang, Yuxuan, Forsberg, Björn O, Carroni, Marta, Yvonnesdotter, Linnea, Howard, Rebecca J, Lindahl, Erik
Publicado 2021

Molecular Mechanism for the Dual Alcohol Modulation of Cys-loop Receptors

por Murail, Samuel, Howard, Rebecca J., Broemstrup, Torben, Bertaccini, Edward J., Harris, R. Adron, Trudell, James R., Lindahl, Erik
Publicado 2012

Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization

por Bondarenko, Vasyl, Chen, Qiang, Singewald, Kevin, Haloi, Nandan, Tillman, Tommy S., Howard, Rebecca J., Lindahl, Erik, Xu, Yan, Tang, Pei
Publicado 2023

Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering

por Lycksell, Marie, Rovšnik, Urška, Bergh, Cathrine, Johansen, Nicolai T., Martel, Anne, Porcar, Lionel, Arleth, Lise, Howard, Rebecca J., Lindahl, Erik
Publicado 2021

Structural insights into opposing actions of neurosteroids on GABA(A) receptors

por Legesse, Dagimhiwat H., Fan, Chen, Teng, Jinfeng, Zhuang, Yuxuan, Howard, Rebecca J., Noviello, Colleen M., Lindahl, Erik, Hibbs, Ryan E.
Publicado 2023

Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium

por Mehregan, Aujan, Pérez-Conesa, Sergio, Zhuang, Yuxuan, Elbahnsi, Ahmad, Pasini, Diletta, Lindahl, Erik, Howard, Rebecca J., Ulens, Chris, Delemotte, Lucie
Publicado 2022

Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site

por Sridhar, Akshay, Lummis, Sarah C.R., Pasini, Diletta, Mehregan, Aujan, Brams, Marijke, Kambara, Kumiko, Bertrand, Daniel, Lindahl, Erik, Howard, Rebecca J., Ulens, Chris
Publicado 2021

Shared structural mechanisms of general anesthetics and benzodiazepines

por Kim, Jeong Joo, Gharpure, Anant, Teng, Jinfeng, Zhuang, Yuxuan, Howard, Rebecca J., Zhu, Shaotong, Noviello, Colleen M., Walsh, Richard M., Lindahl, Erik, Hibbs, Ryan E.
Publicado 2020

MDverse: Shedding Light on the Dark Matter of Molecular Dynamics Simulations

por Tiemann, Johanna K. S., Szczuka, Magdalena, Bouarroudj, Lisa, Oussaren, Mohamed, Garcia, Steven, Howard, Rebecca J., Delemotte, Lucie, Lindahl, Erik, Baaden, Marc, Lindorff-Larsen, Kresten, Chavent, Matthieu, Poulain, Pierre
Publicado 2023

Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids

por Haloi, Nandan, Huang, Shan, Nichols, Aaron L., Fine, Eve J., Friesenhahn, Nicholas J., Marotta, Christopher B., Dougherty, Dennis A., Lindahl, Erik, Howard, Rebecca J., Mayo, Stephen L., Lester, Henry A.
Publicado 2023

Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)

por Spurny, Radovan, Billen, Bert, Howard, Rebecca J., Brams, Marijke, Debaveye, Sarah, Price, Kerry L., Weston, David A., Strelkov, Sergei V., Tytgat, Jan, Bertrand, Sonia, Bertrand, Daniel, Lummis, Sarah C. R., Ulens, Chris
Publicado 2013

A missense mutation converts the Na(+),K(+)-ATPase into an ion channel and causes therapy-resistant epilepsy

por Ygberg, Sofia, Akkuratov, Evgeny E., Howard, Rebecca J., Taylan, Fulya, Jans, Daniel C., Mahato, Dhani R., Katz, Adriana, Kinoshita, Paula F., Portal, Benjamin, Nennesmo, Inger, Lindskog, Maria, Karlish, Steven J.D., Andersson, Magnus, Lindstrand, Anna, Brismar, Hjalmar, Aperia, Anita
Publicado 2021

Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples

por Alekseenko, Alisa, Barrett, Donal, Pareja-Sanchez, Yerma, Howard, Rebecca J., Strandback, Emilia, Ampah-Korsah, Henry, Rovšnik, Urška, Zuniga-Veliz, Silvia, Klenov, Alexander, Malloo, Jayshna, Ye, Shenglong, Liu, Xiyang, Reinius, Björn, Elsässer, Simon J., Nyman, Tomas, Sandh, Gustaf, Yin, Xiushan, Pelechano, Vicent
Publicado 2021

Assessing coastal wetland vulnerability to sea-level rise along the northern Gulf of Mexico coast: Gaps and opportunities for developing a coordinated regional sampling network

por Osland, Michael J., Griffith, Kereen T., Larriviere, Jack C., Feher, Laura C., Cahoon, Donald R., Enwright, Nicholas M., Oster, David A., Tirpak, John M., Woodrey, Mark S., Collini, Renee C., Baustian, Joseph J., Breithaupt, Joshua L., Cherry, Julia A., Conrad, Jeremy R., Cormier, Nicole, Coronado-Molina, Carlos A., Donoghue, Joseph F., Graham, Sean A., Harper, Jennifer W., Hester, Mark W., Howard, Rebecca J., Krauss, Ken W., Kroes, Daniel E., Lane, Robert R., McKee, Karen L., Mendelssohn, Irving A., Middleton, Beth A., Moon, Jena A., Piazza, Sarai C., Rankin, Nicole M., Sklar, Fred H., Steyer, Greg D., Swanson, Kathleen M., Swarzenski, Christopher M., Vervaeke, William C., Willis, Jonathan M., Wilson, K. Van
Publicado 2017