Current and Emerging Detoxification Therapies for Critical Care

por Howell, Brett A., Chauhan, Anuj
Publicado 2010

Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

por Yang, Kyunghee, Woodhead, Jeffrey L, Watkins, Paul B, Howell, Brett A, Brouwer, Kim LR
Publicado 2014

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling

por Woodhead, Jeffrey L, Siler, Scott Q, Howell, Brett A, Watkins, Paul B, Conway, Charles
Publicado 2022

Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses

por Shoda, Lisl KM, Battista, Christina, Siler, Scott Q, Pisetsky, David S, Watkins, Paul B, Howell, Brett A
Publicado 2017

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity

por Battista, Christina, Yang, Kyunghee, Stahl, Simone H, Mettetal, Jerome T, Watkins, Paul B, Siler, Scott Q, Howell, Brett A
Publicado 2018

Assessing Effects of BHV-0223 40 mg Zydis Sublingual Formulation and Riluzole 50 mg Oral Tablet on Liver Function Test Parameters Utilizing DILIsym

por Longo, Diane M, Shoda, Lisl K M, Howell, Brett A, Coric, Vladimir, Berman, Robert M, Qureshi, Irfan A
Publicado 2020

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury

por Woodhead, Jeffrey L., Yang, Kyunghee, Siler, Scott Q., Watkins, Paul B., Brouwer, Kim L. R., Barton, Hugh A., Howell, Brett A.
Publicado 2014

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling

por Woodhead, Jeffrey L., Yang, Kyunghee, Oldach, David, MacLauchlin, Chris, Fernandes, Prabhavathi, Watkins, Paul B., Siler, Scott Q., Howell, Brett A.
Publicado 2019

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition

por Beaudoin, James J., Yang, Kyunghee, Adiwidjaja, Jeffry, Taneja, Guncha, Watkins, Paul B., Siler, Scott Q., Howell, Brett A., Woodhead, Jeffrey L.
Publicado 2023

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

por Longo, Diane M, Woodhead, Jeffrey L, Walker, Paul, Herédi-Szabó, Krisztina, Mogyorósi, Károly, Wolenski, Francis S, Dragan, Yvonne P, Mosedale, Merrie, Siler, Scott Q, Watkins, Paul B, Howell, Brett A
Publicado 2019

Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches

por Bhattacharya, Sudin, Shoda, Lisl K.M., Zhang, Qiang, Woods, Courtney G., Howell, Brett A., Siler, Scott Q., Woodhead, Jeffrey L., Yang, Yuching, McMullen, Patrick, Watkins, Paul B., Andersen, Melvin E.
Publicado 2012

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling

por Woodhead, Jeffrey L., Paech, Franziska, Maurer, Martina, Engelhardt, Marc, Schmitt‐Hoffmann, Anne H., Spickermann, Jochen, Messner, Simon, Wind, Mathias, Witschi, Anne‐Therese, Krähenbühl, Stephan, Siler, Scott Q., Watkins, Paul B., Howell, Brett A.
Publicado 2018

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

por Generaux, Grant, Lakhani, Vinal V., Yang, Yuching, Nadanaciva, Sashi, Qiu, Luping, Riccardi, Keith, Di, Li, Howell, Brett A., Siler, Scott Q., Watkins, Paul B., Barton, Hugh A., Aleo, Michael D., Shoda, Lisl K. M.
Publicado 2019

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanist...

por Beaudoin, James J., Clemens, Lara, Miedel, Mark T., Gough, Albert, Zaidi, Fatima, Ramamoorthy, Priya, Wong, Kari E., Sarangarajan, Rangaprasad, Battista, Christina, Shoda, Lisl K. M., Siler, Scott Q., Taylor, D. Lansing, Howell, Brett A., Vernetti, Lawrence A., Yang, Kyunghee
Publicado 2023

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

por Woodhead, Jeffrey L., Brock, William J., Roth, Sharin E., Shoaf, Susan E., Brouwer, Kim L.R., Church, Rachel, Grammatopoulos, Tom N., Stiles, Linsey, Siler, Scott Q., Howell, Brett A., Mosedale, Merrie, Watkins, Paul B., Shoda, Lisl K.M.
Publicado 2017