New Paradigms to Assess Consequences of Long-Term, Low-Dose Curcumin Exposure in Lung Cancer Cells

por Smagurauskaite, Gintare, Mahale, Jagdish, Brown, Karen, Thomas, Anne L., Howells, Lynne M.
Publicado 2020

The utility of ctDNA in detecting minimal residual disease following curative surgery in colorectal cancer: a systematic review and meta-analysis

por Faulkner, Lucy G., Howells, Lynne M., Pepper, Coral, Shaw, Jacqueline A., Thomas, Anne L.
Publicado 2022

Effects of Omegaven®, EPA, DHA and oxaliplatin on oesophageal adenocarcinoma cell lines growth, cytokine and cell signal biomarkers expression

por Eltweri, Amar M., Howells, Lynne M., Thomas, Anne L., Dennison, Ashley R., Bowrey, David J.
Publicado 2018

Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line

por Hudson, E Ann, Howells, Lynne M, Gallacher-Horley, Barbara, Fox, Louise H, Gescher, Andreas, Manson, Margaret M
Publicado 2003

Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants

por Miles, Gareth J, Powley, Ian, Mohammed, Seid, Howells, Lynne, Pringle, J. Howard, Hammonds, Tim, MacFarlane, Marion, Pritchard, Catrin
Publicado 2021

Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial

por Irving, Glen RB, Iwuji, Chinenye OO, Morgan, Bruno, Berry, David P, Steward, William P, Thomas, Anne, Brown, Karen, Howells, Lynne M
Publicado 2015

Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery

por Powley, Ian R., Patel, Meeta, Miles, Gareth, Pringle, Howard, Howells, Lynne, Thomas, Anne, Kettleborough, Catherine, Bryans, Justin, Hammonds, Tim, MacFarlane, Marion, Pritchard, Catrin
Publicado 2020

Ex vivo explant model of adenoma and colorectal cancer to explore mechanisms of action and patient response to cancer prevention therapies

por Khan, Sam, Miles, Gareth J, Demetriou, Constantinos, Sidat, Zahirah, Foreman, Nalini, West, Kevin, Karmokar, Ankur, Howells, Lynne, Pritchard, Catrin, Thomas, Anne L, Brown, Karen
Publicado 2022

Myeloid derived suppressor cells are reduced and T regulatory cells stabilised in patients with advanced pancreatic cancer treated with gemcitabine and intravenous omega 3

por Isherwood, John, Arshad, Ali, Chung, Wen Yuan, Runau, Franscois, Cooke, Jill, Pollard, Cristina, Howells, Lynne, Fishwick, Jenny, Thompson, John, Metcalfe, Matthew, Steward, William, Dennison, Ashley
Publicado 2020

Characterization and Propagation of Tumor Initiating Cells Derived from Colorectal Liver Metastases: Trials, Tribulations and a Cautionary Note

por James, Mark I., Howells, Lynne M., Karmokar, Ankur, Higgins, Jennifer A., Greaves, Peter, Cai, Hong, Dennison, Ashley, Metcalfe, Matthew, Garcea, Giuseppe, Lloyd, David M., Berry, David P., Steward, William P., Brown, Karen
Publicado 2015

Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway

por Ruiz de Porras, Vicenç, Bystrup, Sara, Martínez-Cardús, Anna, Pluvinet, Raquel, Sumoy, Lauro, Howells, Lynne, James, Mark I., Iwuji, Chinenye, Manzano, José Luis, Layos, Laura, Bugés, Cristina, Abad, Albert, Martínez-Balibrea, Eva
Publicado 2016

A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps

por Briata, Irene Maria, Paleari, Laura, Rutigliani, Mariangela, Petrera, Marilena, Caviglia, Silvia, Romagnoli, Paola, Libera, Mauro Dalla, Oppezzi, Massimo, Puntoni, Matteo, Siri, Giacomo, Lazzeroni, Matteo, Howells, Lynne, Singh, Raj, Brown, Karen, DeCensi, Andrea
Publicado 2021

Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial

por Howells, Lynne M, Iwuji, Chinenye O O, Irving, Glen R B, Barber, Shaun, Walter, Harriet, Sidat, Zahirah, Griffin-Teall, Nicola, Singh, Rajinder, Foreman, Nalini, Patel, Samita R, Morgan, Bruno, Steward, William P, Gescher, Andreas, Thomas, Anne L, Brown, Karen
Publicado 2019

Clinical trials in cancer screening, prevention and early diagnosis (SPED): a systematic mapping review

por O’Dowd, Emma L., Merriel, Samuel W. D., Cheng, Vinton W. T., Khan, Sam, Howells, Lynne M., Gopal, Dipesh P., Roundhill, Elizabeth A., Brennan, Paul M., Crosbie, Philip A. J., Neal, Richard D., Brown, Karen, Crosbie, Emma J., Baldwin, David R.
Publicado 2023

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

por Alexandrou, Constantinos, Al-Aqbi, Saif Sattar, Higgins, Jennifer A., Boyle, William, Karmokar, Ankur, Andreadi, Catherine, Luo, Jin-Li, Moore, David A., Viskaduraki, Maria, Blades, Matthew, Murray, Graeme I., Howells, Lynne M., Thomas, Anne, Brown, Karen, Cheng, Paul N., Rufini, Alessandro
Publicado 2018

Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells

por Alaqbi, Saif Sattar, Burke, Lynsey, Guterman, Inna, Green, Caleb, West, Kevin, Palacios-Gallego, Raquel, Cai, Hong, Alexandrou, Constantinos, Myint, Ni Ni Moe, Parrott, Emma, Howells, Lynne M., Higgins, Jennifer A., Jones, Donald J. L., Singh, Rajinder, Britton, Robert G., Tufarelli, Cristina, Thomas, Anne, Rufini, Alessandro
Publicado 2022

Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy

por James, Mark I., Iwuji, Chinenye, Irving, Glen, Karmokar, Ankur, Higgins, Jennifer A., Griffin-Teal, Nicola, Thomas, Anne, Greaves, Peter, Cai, Hong, Patel, Samita R., Morgan, Bruno, Dennison, Ashley, Metcalfe, Matthew, Garcea, Giuseppe, Lloyd, David M., Berry, David P., Steward, William P., Howells, Lynne M., Brown, Karen
Publicado 2015

Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity

por Myint, Ni Ni Moe, Verma, Ajay M., Fernandez-Garcia, Daniel, Sarmah, Panchali, Tarpey, Patrick S., Al-Aqbi, Saif Sattar, Cai, Hong, Trigg, Ricky, West, Kevin, Howells, Lynne M., Thomas, Anne, Brown, Karen, Guttery, David S., Singh, Baljit, Pringle, Howard J., McDermott, Ultan, Shaw, Jacqui A., Rufini, Alessandro
Publicado 2018