A robust and efficient method for Mendelian randomization with hundreds of genetic variants

por Burgess, Stephen, Foley, Christopher N, Allara, Elias, Staley, James R, Howson, Joanna M. M.
Publicado 2020

Genetic Analysis of Adult-Onset Autoimmune Diabetes

por Howson, Joanna M.M., Rosinger, Silke, Smyth, Deborah J., Boehm, Bernhard O., Todd, John A.
Publicado 2011

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants

por Persyn, Elodie, Hanscombe, Ken B., Howson, Joanna M. M., Lewis, Cathryn M., Traylor, Matthew, Markus, Hugh S.
Publicado 2020

A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design

por Staley, James R, Jones, Edmund, Kaptoge, Stephen, Butterworth, Adam S, Sweeting, Michael J, Wood, Angela M, Howson, Joanna M M
Publicado 2017

Evidence That HLA Class I and II Associations With Type 1 Diabetes, Autoantibodies to GAD and Autoantibodies to IA-2, Are Distinct

por Howson, Joanna M.M., Stevens, Helen, Smyth, Deborah J., Walker, Neil M., Chandler, Kyla A., Bingley, Polly J., Todd, John A.
Publicado 2011

An atlas of mitochondrial DNA genotype-phenotype associations in the UK Biobank

por Yonova-Doing, Ekaterina, Calabrese, Claudia, Gomez-Duran, Aurora, Schon, Katherine, Wei, Wei, Karthikeyan, Savita, Chinnery, Patrick F., Howson, Joanna M. M.
Publicado 2021

A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits

por Foley, Christopher N., Staley, James R., Breen, Philip G., Sun, Benjamin B., Kirk, Paul D. W., Burgess, Stephen, Howson, Joanna M. M.
Publicado 2021

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

por Abraham, Gad, Malik, Rainer, Yonova-Doing, Ekaterina, Salim, Agus, Wang, Tingting, Danesh, John, Butterworth, Adam S., Howson, Joanna M. M., Inouye, Michael, Dichgans, Martin
Publicado 2019

Author Correction: Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

por Abraham, Gad, Malik, Rainer, Yonova-Doing, Ekaterina, Salim, Agus, Wang, Tingting, Danesh, John, Butterworth, Adam S., Howson, Joanna M. M., Inouye, Michael, Dichgans, Martin
Publicado 2020

Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling

por Karhunen, Ville, Daghlas, Iyas, Zuber, Verena, Vujkovic, Marijana, Olsen, Anette K., Knudsen, Lotte Bjerre, Haynes, William G., Howson, Joanna M. M., Gill, Dipender
Publicado 2021

FUT2 Nonsecretor Status Links Type 1 Diabetes Susceptibility and Resistance to Infection

por Smyth, Deborah J., Cooper, Jason D., Howson, Joanna M.M., Clarke, Pamela, Downes, Kate, Mistry, Trupti, Stevens, Helen, Walker, Neil M., Todd, John A.
Publicado 2011

Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups

por Georgakis, Marios K., Malik, Rainer, Richardson, Tom G., Howson, Joanna M. M., Anderson, Christopher D., Burgess, Stephen, Hovingh, G. Kees, Dichgans, Martin, Gill, Dipender
Publicado 2022

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

por Saleh, Nada M, Raj, Srilakshmi M, Smyth, Deborah J, Wallace, Chris, Howson, Joanna M M, Bell, Louise, Walker, Neil M, Stevens, Helen E, Todd, John A
Publicado 2011

An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes

por Swafford, Austin D.-E., Howson, Joanna M.M., Davison, Lucy J., Wallace, Chris, Smyth, Deborah J., Schuilenburg, Helen, Maisuria-Armer, Meeta, Mistry, Trupti, Lenardo, Michael J., Todd, John A.
Publicado 2011

Genome-Wide Association Analysis of Autoantibody Positivity in Type 1 Diabetes Cases

por Plagnol, Vincent, Howson, Joanna M. M., Smyth, Deborah J., Walker, Neil, Hafler, Jason P., Wallace, Chris, Stevens, Helen, Jackson, Laura, Simmonds, Matthew J., Bingley, Polly J., Gough, Stephen C., Todd, John A.
Publicado 2011

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients

por Downes, Kate, Marcovecchio, M. Loredana, Clarke, Pamela, Cooper, Jason D., Ferreira, Ricardo C., Howson, Joanna M. M., Jolley, Jennifer, Nutland, Sarah, Stevens, Helen E., Walker, Neil M., Wallace, Chris, Dunger, David B., Todd, John A.
Publicado 2013

Genetic Evidence for Repurposing of GLP1R (Glucagon‐Like Peptide‐1 Receptor) Agonists to Prevent Heart Failure

por Daghlas, Iyas, Karhunen, Ville, Ray, Devleena, Zuber, Verena, Burgess, Stephen, Tsao, Philip S., Lynch, Julie A., Lee, Kyung Min, Voight, Benjamin F., Chang, Kyong‐Mi, Baker, Emma H., Damrauer, Scott M., Howson, Joanna M. M., Vujkovic, Marijana, Gill, Dipender
Publicado 2021

Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes

por Cooper, Nicholas J., Shtir, Corina J., Smyth, Deborah J., Guo, Hui, Swafford, Austin D., Zanda, Manuela, Hurles, Matthew E., Walker, Neil M., Plagnol, Vincent, Cooper, Jason D., Howson, Joanna M.M., Burren, Oliver S., Onengut-Gumuscu, Suna, Rich, Stephen S., Todd, John A.
Publicado 2015

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes

por Howson, Joanna M.M., Cooper, Jason D., Smyth, Deborah J., Walker, Neil M., Stevens, Helen, She, Jin-Xiong, Eisenbarth, George S., Rewers, Marian, Todd, John A., Akolkar, Beena, Concannon, Patrick, Erlich, Henry A., Julier, Cécile, Morahan, Grant, Nerup, Jørn, Nierras, Concepcion, Pociot, Flemming, Rich, Stephen S.
Publicado 2012

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

por Ferreira, Ricardo C., Freitag, Daniel F., Cutler, Antony J., Howson, Joanna M. M., Rainbow, Daniel B., Smyth, Deborah J., Kaptoge, Stephen, Clarke, Pamela, Boreham, Charlotte, Coulson, Richard M., Pekalski, Marcin L., Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S., Butterworth, Adam S., Malarstig, Anders, Danesh, John, Todd, John A.
Publicado 2013