Intermolecular Interactions of Nucleoside Antibiotic Tunicamycin with On-Target MraY(CB)-TUN and Off-Target DPAGT1-TUN in the Active Sites Delineated by Quantum Mechanics/Molecular...

por Astani, Elahe K., Malek Zadeh, Saeid, Hsu, Ning-Shian, Lin, Kuan-Hung, Sardari, Soroush, Li, Tsung-Lin
Publicado 2022

KasQ an Epimerase Primes the Biosynthesis of Aminoglycoside Antibiotic Kasugamycin and KasF/H Acetyltransferases Inactivate Its Activity

por Rattinam, Rajesh, Basha, R. Sidick, Wang, Yung-Lin, Wang, Zhe-Chong, Hsu, Ning-Shian, Lin, Kuan-Hung, Zadeh, Saeid Malek, Adhikari, Kamal, Lin, Jin-Ping, Li, Tsung-Lin
Publicado 2022

Biochemical and structural explorations of α-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction

por Yeh, Hsien-Wei, Lin, Kuan-Hung, Lyu, Syue-Yi, Li, Yi-Shan, Huang, Chun-Man, Wang, Yung-Lin, Shih, Hao-Wei, Hsu, Ning-Shian, Wu, Chang-Jer, Li, Tsung-Lin
Publicado 2019

The flavin mononucleotide cofactor in α-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level

por Lyu, Syue-Yi, Lin, Kuan-Hung, Yeh, Hsien-Wei, Li, Yi-Shan, Huang, Chun-Man, Wang, Yung-Lin, Shih, Hao-Wei, Hsu, Ning-Shian, Wu, Chang-Jer, Li, Tsung-Lin
Publicado 2019

Evidence of Diradicals Involved in the Yeast Transketolase Catalyzed Keto‐Transferring Reactions

por Hsu, Ning‐Shian, Wang, Yung‐Lin, Lin, Kuan‐Hung, Chang, Chi‐Fon, Ke, Shyue‐Chu, Lyu, Syue‐Yi, Hsu, Li‐Jen, Li, Yi‐Shan, Chen, Sheng‐Chia, Wang, Kuei‐Chen, Li, Tsung‐Lin
Publicado 2018

Structural and chemical trapping of flavin‐oxide intermediates reveals substrate‐directed reaction multiplicity

por Lin, Kuan‐Hung, Lyu, Syue‐Yi, Yeh, Hsien‐Wei, Li, Yi‐Shan, Hsu, Ning‐Shian, Huang, Chun‐Man, Wang, Yung‐Lin, Shih, Hao‐Wei, Wang, Zhe‐Chong, Wu, Chang‐Jer, Li, Tsung‐Lin
Publicado 2020

N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry

por Wang, Yung-Lin, Chang, Chin-Yuan, Hsu, Ning-Shian, Lo, I-Wen, Lin, Kuan-Hung, Chen, Chun-Liang, Chang, Chi-Fon, Wang, Zhe-Chong, Ogasawara, Yasushi, Dairi, Tohru, Maruyama, Chitose, Hamano, Yoshimitsu, Li, Tsung-Lin
Publicado 2023

β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin

por Zadeh, Saeid Malek, Chen, Mei-Hua, Wang, Zhe-Chong, Astani, Elahe K., Lo, I-Wen, Lin, Kuan-Hung, Hsu, Ning-Shian, Adhikari, Kamal, Lyu, Syue-Yi, Tsai, Hsin-Ying, Terasawa, Yuma, Yabe, Miyuki, Yamamoto, Kazuki, Ichikawa, Satoshi, Li, Tsung-Lin
Publicado 2022