Expression defect of the rare variant/Brugada mutation R1512W depends upon the SCN5A splice variant background and can be rescued by mexiletine and the common polymorphism H558R

por Hu, Rou-Mu, Song, Evelyn J., Tester, David J., Deschenes, Isabelle, Ackerman, Michael J., Makielski, Jonathan C., Tan, Bi-Hua
Publicado 2021

Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5A mutation, N406K, found in LQT3 patients

por Hu, Rou-Mu, Tester, David J., Li, Ryan, Sun, Tianyu, Peterson, Blaise Z., Ackerman, Michael J., Makielski, Jonathan C., Tan, Bi-Hua
Publicado 2018

Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis

por Hu, Rou-Mu, Tan, Bi-Hua, Tester, David J., Song, Chunhua, He, Yang, Dovat, Sinisa, Peterson, Blaise Z., Ackerman, Michael J., Makielski, Jonathan C.
Publicado 2015

Investigation of the Cellular Pharmacological Mechanism and Clinical Evidence of the Multi-Herbal Antiarrhythmic Chinese Medicine Xin Su Ning

por Ma, Yu-ling, Hu, Rou-Mu, Yang, Xinchun, Wang, Taiyi, Noble, Penelope J., Wilkins, Robert, Ellory, Clive, Carr, Carolyn, Noble, Denis, Yang, Jiefu, Lu, Weixing, Zhang, Junhua, Hu, Hongde, Guo, Xiaomei, Chen, Min, Wu, Yang, Wei, Meng, Mao, Jingyuan, Ma, Xiaochang, Qin, Ling, Wu, Huanlin, Lu, Feng, Cao, Ying, Gao, Sheng, Gu, Wanli
Publicado 2020