Machine learning classifier approaches for predicting response to RTK-type-III inhibitors demonstrate high accuracy using transcriptomic signatures and ex vivo data

por Ferrato, Mauricio H, Marsh, Adam G, Franke, Karl R, Huang, Benjamin J, Kolb, E Anders, DeRyckere, Deborah, Grahm, Douglas K, Chandrasekaran, Sunita, Crowgey, Erin L
Publicado 2023

Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation

por Chen, Pan-Yu, Huang, Benjamin J., Harris, Max, Boone, Christopher, Wang, Weijie, Carias, Heidi, Mesiona, Brian, Mavrici, Daniela, Kohler, Amanda C., Bollag, Gideon, Zhang, Chao, Zhang, Ying, Shannon, Kevin
Publicado 2023

Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias

por Huang, Benjamin J., Wandler, Anica M., Meyer, Lauren K., Dail, Monique, Daemen, Anneleen, Sampath, Deepak, Li, Qing, Wang, Xinyue, Wong, Jasmine C., Nakitandwe, Joy, Downing, James R., Zhang, Jinghui, Taylor, Barry S., Shannon, Kevin
Publicado 2019

Inhibition of the Sec61 translocon overcomes cytokine‐induced glucocorticoid resistance in T‐cell acute lymphoblastic leukaemia

por Meyer, Lauren K., Delgado‐Martin, Cristina, Sharp, Phillip P., Huang, Benjamin J., McMinn, Dustin, Vincent, Tiffaney L., Ryan, Theresa, Horton, Terzah M., Wood, Brent L., Teachey, David T., Taunton, Jack, Kirk, Christopher J., Hermiston, Michelle L.
Publicado 2022

Framework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies

por Temple, William C, Nix, Matthew A, Naik, Akul, Izgutdina, Adila, Huang, Benjamin J, Wicaksono, Gianina, Phojanakong, Paul, Serrano, Juan Antonio Camara, Young, Elizabeth P, Ramos, Emilio, Salangsang, Fernando, Steri, Veronica, Xirenayi, Simayijiang, Hermiston, Michelle, Logan, Aaron C, Stieglitz, Elliot, Wiita, Arun P
Publicado 2023

Proposal of a new genomic framework for categorization of pediatric acute myeloid leukemia associated with prognosis

por Umeda, Masayuki, Ma, Jing, Westover, Tamara, Ni, Yonghui, Song, Guangchun, Maciaszek, Jamie L., Rusch, Michael, Rahbarinia, Delaram, Foy, Scott, Huang, Benjamin J., Walsh, Michael P., Kumar, Priyadarshini, Liu, Yanling, Fan, Yiping, Wu, Gang, Baker, Sharyn D., Ma, Xiaotu, Wang, Lu, Rubnitz, Jeffrey E., Pounds, Stanley, Klco, Jeffery M.
Publicado 2023

Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia

por Farrar, Jason E., Smith, Jenny L., Othus, Megan, Huang, Benjamin J., Wang, Yi-Cheng, Ries, Rhonda, Hylkema, Tiffany, Pogosova-Agadjanyan, Era L., Challa, Sneha, Leonti, Amanda, Shaw, Timothy I., Triche, Timothy J., Gamis, Alan S., Aplenc, Richard, Kolb, E. Anders, Ma, Xiaotu, Stirewalt, Derek L., Alonzo, Todd A., Meshinchi, Soheil
Publicado 2023

CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes

por Huang, Benjamin J., Smith, Jenny L., Wang, Yi-Cheng, Taghizadeh, Kassra, Leonti, Amanda R., Ries, Rhonda E., Liu, Yanling, Kolekar, Pandurang, Tarlock, Katherine, Gerbing, Robert, Crowgey, Erin, Furlan, Scott N., Shaw, Timothy I., Hagiwara, Kohei, Wei, Lisa, Cooper, Todd M., Gamis, Alan S., Aplenc, Richard, Kolb, E. Anders, Farrar, Jason E., Triche, Timothy, Alonzo, Todd A., Ma, Xiaotu, Meshinchi, Soheil
Publicado 2021

Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia

por Huang, Benjamin J., Smith, Jenny L., Farrar, Jason E., Wang, Yi-Cheng, Umeda, Masayuki, Ries, Rhonda E., Leonti, Amanda R., Crowgey, Erin, Furlan, Scott N., Tarlock, Katherine, Armendariz, Marcos, Liu, Yanling, Shaw, Timothy I., Wei, Lisa, Gerbing, Robert B., Cooper, Todd M., Gamis, Alan S., Aplenc, Richard, Kolb, E. Anders, Rubnitz, Jeffrey, Ma, Jing, Klco, Jeffery M., Ma, Xiaotu, Alonzo, Todd A., Triche, Timothy, Meshinchi, Soheil
Publicado 2022

Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication

por Liu, Yanling, Klein, Jonathon, Bajpai, Richa, Dong, Li, Tran, Quang, Kolekar, Pandurang, Smith, Jenny L., Ries, Rhonda E., Huang, Benjamin J., Wang, Yi-Cheng, Alonzo, Todd A., Tian, Liqing, Mulder, Heather L., Shaw, Timothy I., Ma, Jing, Walsh, Michael P., Song, Guangchun, Westover, Tamara, Autry, Robert J., Gout, Alexander M., Wheeler, David A., Wan, Shibiao, Wu, Gang, Yang, Jun J., Evans, William E., Loh, Mignon, Easton, John, Zhang, Jinghui, Klco, Jeffery M., Meshinchi, Soheil, Brown, Patrick A., Pruett-Miller, Shondra M., Ma, Xiaotu
Publicado 2023

CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target

por Le, Quy, Hadland, Brandon, Smith, Jenny L., Leonti, Amanda, Huang, Benjamin J., Ries, Rhonda, Hylkema, Tiffany A., Castro, Sommer, Tang, Thao T., McKay, Cyd N., Perkins, LaKeisha, Pardo, Laura, Sarthy, Jay, Beckman, Amy K., Williams, Robin, Idemmili, Rhonda, Furlan, Scott, Ishida, Takashi, Call, Lindsey, Srivastava, Shivani, Loeb, Anisha M., Milano, Filippo, Imren, Suzan, Morris, Shelli M., Pakiam, Fiona, Olson, Jim M., Loken, Michael R., Brodersen, Lisa, Riddell, Stanley R., Tarlock, Katherine, Bernstein, Irwin D., Loeb, Keith R., Meshinchi, Soheil
Publicado 2022

Structural surfaceomics reveals an AML-specific conformation of integrin β(2) as a CAR T cellular therapy target

por Mandal, Kamal, Wicaksono, Gianina, Yu, Clinton, Adams, Jarrett J., Hoopmann, Michael R., Temple, William C., Izgutdina, Adila, Escobar, Bonell Patiño, Gorelik, Maryna, Ihling, Christian H., Nix, Matthew A., Naik, Akul, Xie, William H., Hübner, Juwita, Rollins, Lisa A., Reid, Sandy M., Ramos, Emilio, Kasap, Corynn, Steri, Veronica, Serrano, Juan Antonio Camara, Salangsang, Fernando, Phojanakong, Paul, McMillan, Melanie, Gavallos, Victor, Leavitt, Andrew D., Logan, Aaron C., Rooney, Cliona M., Eyquem, Justin, Sinz, Andrea, Huang, Benjamin J., Stieglitz, Elliot, Smith, Catherine C., Moritz, Robert L., Sidhu, Sachdev S., Huang, Lan, Wiita, Arun P.
Publicado 2023

Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia

por Umeda, Masayuki, Ma, Jing, Huang, Benjamin J., Hagiwara, Kohei, Westover, Tamara, Abdelhamed, Sherif, Barajas, Juan M., Thomas, Melvin E., Walsh, Michael P., Song, Guangchun, Tian, Liqing, Liu, Yanling, Chen, Xiaolong, Kolekar, Pandurang, Tran, Quang, Foy, Scott G., Maciaszek, Jamie L., Kleist, Andrew B., Leonti, Amanda R., Ju, Bengsheng, Easton, John, Wu, Huiyun, Valentine, Virginia, Valentine, Marcus B., Liu, Yen-Chun, Ries, Rhonda E., Smith, Jenny L., Parganas, Evan, Iacobucci, Ilaria, Hiltenbrand, Ryan, Miller, Jonathan, Myers, Jason R., Rampersaud, Evadnie, Rahbarinia, Delaram, Rusch, Michael, Wu, Gang, Inaba, Hiroto, Wang, Yi-Cheng, Alonzo, Todd A., Downing, James R., Mullighan, Charles G., Pounds, Stanley, Babu, M. Madan, Zhang, Jinghui, Rubnitz, Jeffrey E., Meshinchi, Soheil, Ma, Xiaotu, Klco, Jeffery M.
Publicado 2022