BH3 Mimetics for the Treatment of B-Cell Malignancies—Insights and Lessons from the Clinic

por Lin, Victor S., Xu, Zhuo-Fan, Huang, David C. S., Thijssen, Rachel
Publicado 2020

Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics

por Cragg, Mark S, Kuroda, Junya, Puthalakath, Hamsa, Huang, David C. S, Strasser, Andreas
Publicado 2007

Current Advances and Future Strategies for BCL-2 Inhibitors: Potent Weapons against Cancers

por Xu, Jiaxuan, Dong, Xiaoqing, Huang, David C. S., Xu, Peipei, Zhao, Quan, Chen, Bing
Publicado 2023

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

por Uren, Rachel T., Dewson, Grant, Chen, Lin, Coyne, Stephanie C., Huang, David C.S., Adams, Jerry M., Kluck, Ruth M.
Publicado 2007

Debcl, a Proapoptotic Bcl-2 Homologue, Is a Component of the Drosophila melanogaster Cell Death Machinery

por Colussi, Paul A., Quinn, Leonie M., Huang, David C.S., Coombe, Michelle, Read, Stuart H., Richardson, Helena, Kumar, Sharad
Publicado 2000

Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-X(L)

por Hausmann, George, O'Reilly, Lorraine A., van Driel, Rosemary, Beaumont, Jennifer G., Strasser, Andreas, Adams, Jerry M., Huang, David C.S.
Publicado 2000

Loss of RIPK3 does not impact MYC-driven lymphomagenesis or chemotherapeutic drug-induced killing of malignant lymphoma cells

por Thijssen, Rachel, Alvarez-Diaz, Silvia, Grace, Clea, Gao, Ming-yuan, Segal, David H., Xu, Zhen, Strasser, Andreas, Huang, David C. S.
Publicado 2020

MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication

por Fleming, Peter, Kvansakul, Marc, Voigt, Valentina, Kile, Benjamin T., Kluck, Ruth M., Huang, David C. S., Degli-Esposti, Mariapia A., Andoniou, Christopher E.
Publicado 2013

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

por Kvansakul, Marc, Wei, Andrew H., Fletcher, Jamie I., Willis, Simon N., Chen, Lin, Roberts, Andrew W., Huang, David C. S., Colman, Peter M.
Publicado 2010

A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation

por Wölwer, Christina B., Pase, Luke B., Pearson, Helen B., Gödde, Nathan J., Lackovic, Kurt, Huang, David C. S., Russell, Sarah M., Humbert, Patrick O.
Publicado 2015

Variability of Inducible Expression across the Hematopoietic System of Tetracycline Transactivator Transgenic Mice

por Takiguchi, Megumi, Dow, Lukas E., Prier, Julia E., Carmichael, Catherine L., Kile, Benjamin T., Turner, Stephen J., Lowe, Scott W., Huang, David C. S., Dickins, Ross A.
Publicado 2013

The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia

por Ko, Tun Kiat, Chin, Hui San, Chuah, Charles T.H., Huang, John W.J., Ng, King-Pan, Khaw, Seong Lin, Huang, David C.S., Ong, S. Tiong
Publicado 2015

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

por Iyer, Sweta, Anwari, Khatira, Alsop, Amber E., Yuen, Wai Shan, Huang, David C. S., Carroll, John, Smith, Nicholas A., Smith, Brian J., Dewson, Grant, Kluck, Ruth M.
Publicado 2016

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

por McKenzie, Mark D., Jamieson, Emma, Jansen, Elisa S., Scott, Clare L., Huang, David C.S., Bouillet, Philippe, Allison, Janette, Kay, Thomas W.H., Strasser, Andreas, Thomas, Helen E.
Publicado 2010

BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming

por Kim, Esther J.Y., Anko, Minna-Liisa, Flensberg, Christoffer, Majewski, Ian J., Geng, Fan-Suo, Firas, Jaber, Huang, David C.S., van Delft, Mark F., Heath, Joan K.
Publicado 2018

MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex

por Djajawi, Tirta Mario, Liu, Lei, Gong, Jia-nan, Huang, Allan Shuai, Luo, Ming-jie, Xu, Zhen, Okamoto, Toru, Call, Melissa J., Huang, David C. S., van Delft, Mark F.
Publicado 2020

Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

por Masamsetti, V. Pragathi, Low, Ronnie Ren Jie, Mak, Ka Sin, O’Connor, Aisling, Riffkin, Chris D., Lamm, Noa, Crabbe, Laure, Karlseder, Jan, Huang, David C. S., Hayashi, Makoto T., Cesare, Anthony J.
Publicado 2019

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

por Lee, Erinna F., Czabotar, Peter E., van Delft, Mark F., Michalak, Ewa M., Boyle, Michelle J., Willis, Simon N., Puthalakath, Hamsa, Bouillet, Philippe, Colman, Peter M., Huang, David C.S., Fairlie, W. Douglas
Publicado 2008

Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia

por McArthur, Kate, D’Cruz, Akshay A., Segal, David, Lackovic, Kurt, Wilks, Andrew F., O’Donnell, Joanne A., Nowell, Cameron J., Gerlic, Motti, Huang, David C.S., Burns, Christopher J., Croker, Ben A.
Publicado 2017

Transcriptional silencing of fetal hemoglobin expression by NonO

por Li, Xinyu, Chen, Mengxia, Liu, Biru, Lu, Peifen, Lv, Xiang, Zhao, Xiang, Cui, Shuaiying, Xu, Peipei, Nakamura, Yukio, Kurita, Ryo, Chen, Bing, Huang, David C S, Liu, De-Pei, Liu, Ming, Zhao, Quan
Publicado 2021