Leveraging Bulk and Single-Cell RNA Sequencing Data of NSCLC Tumor Microenvironment and Therapeutic Potential of NLOC-15A, A Novel Multi-Target Small Molecule

por Lawal, Bashir, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2022

BC-N102 suppress breast cancer tumorigenesis by interfering with cell cycle regulatory proteins and hormonal signaling, and induction of time-course arrest of cell cycle at G1/G0 p...

por Lawal, Bashir, Kuo, Yu-Cheng, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2021

Pro-Oncogenic c-Met/EGFR, Biomarker Signatures of the Tumor Microenvironment are Clinical and Therapy Response Prognosticators in Colorectal Cancer, and Therapeutic Targets of 3-Ph...

por Lawal, Bashir, Wang, Yu-Chi, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2021

A new niclosamide derivatives‐B17 can inhibit urological cancers growth through apoptosis‐related pathway

por Wu, Chia‐Lun, Chen, Chun‐Liang, Huang, Hsu‐Shan, Yu, Dah‐Shyong
Publicado 2018

In silico study of novel niclosamide derivatives, SARS-CoV-2 nonstructural proteins catalytic residue-targeting small molecules drug candidates

por Lawal, Bashir, Tsai, Sheng-Kuang, Wu, Alexander T.H., Huang, Hsu-Shan
Publicado 2023

In Silico Evaluation of HN-N07 Small Molecule as an Inhibitor of Angiogenesis and Lymphangiogenesis Oncogenic Signatures in Non-Small Cell Lung Cancer

por Chen, Lung-Ching, Mokgautsi, Ntlotlang, Kuo, Yu-Cheng, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2023

Comprehensive Omics Analysis of a Novel Small-Molecule Inhibitor of Chemoresistant Oncogenic Signatures in Colorectal Cancer Cell with Antitumor Effects

por Huang, Tse-Hung, Mokgautsi, Ntlotlang, Huang, Yan-Jiun, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2021

In vivo Pharmacokinetic and Anticancer Studies of HH-N25, a Selective Inhibitor of Topoisomerase I, and Hormonal Signaling for Treating Breast Cancer

por Lawal, Bashir, Kuo, Yu-Cheng, Sumitra, Maryam Rachmawati, Wu, Alexander T H, Huang, Hsu-Shan
Publicado 2021

Multi-Omics Identification of Genetic Alterations in Head and Neck Squamous Cell Carcinoma and Therapeutic Efficacy of HNC018 as a Novel Multi-Target Agent for c-MET/STAT3/AKT Sign...

por Khedkar, Harshita Nivrutti, Chen, Lung-Ching, Kuo, Yu-Cheng, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2023

Identification of CDK1, PBK, and CHEK1 as an Oncogenic Signature in Glioblastoma: A Bioinformatics Approach to Repurpose Dapagliflozin as a Therapeutic Agent

por Chinyama, Harold A., Wei, Li, Mokgautsi, Ntlotlang, Lawal, Bashir, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2023

CC12 Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Lines and Mouse Xenograft Model

por Fann, Li-Yun, Shih, Jui-Hu, Tseng, Jen-Ho, Huang, Hsu-Shan, Hsiao, Sheng-Huang
Publicado 2020

Identification of a novel immune-inflammatory signature of COVID-19 infections, and evaluation of pharmacokinetics and therapeutic potential of RXn-02, a novel small-molecule deriv...

por Lawal, Bashir, Kuo, Yu-Cheng, Rachmawati Sumitra, Maryam, Wu, Alexander T.H., Huang, Hsu-Shan
Publicado 2022

Multiomics Study of a Novel Naturally Derived Small Molecule, NSC772864, as a Potential Inhibitor of Proto-Oncogenes Regulating Cell Cycle Progression in Colorectal Cancer

por Mokgautsi, Ntlotlang, Kuo, Yu-Cheng, Chen, Chien-Hsin, Huang, Yan-Jiun, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2023

γ-Mangostin isolated from Garcinia mangostana L. suppresses inflammation and alleviates symptoms of osteoarthritis via modulating miR-124-3p/IL-6/NF-κB signaling

por Chiu, Yen-Shuo, Wu, Jia-Lin, Yeh, Chi-Tai, Yadav, Vijesh Kumar, Huang, Hsu-Shan, Wang, Liang-Shun
Publicado 2020

Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines

por Lawal, Bashir, Liu, Yen-Lin, Mokgautsi, Ntlotlang, Khedkar, Harshita, Sumitra, Maryam Rachmawati, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2021

An Integrated Bioinformatics Study of a Novel Niclosamide Derivative, NSC765689, a Potential GSK3β/β-Catenin/STAT3/CD44 Suppressor with Anti-Glioblastoma Properties

por Mokgautsi, Ntlotlang, Wen, Ya-Ting, Lawal, Bashir, Khedkar, Harshita, Sumitra, Maryam Rachmawati, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2021

Network Pharmacological Analysis through a Bioinformatics Approach of Novel NSC765600 and NSC765691 Compounds as Potential Inhibitors of CCND1/CDK4/PLK1/CD44 in Cancer Types

por Mokgautsi, Ntlotlang, Wang, Yu-Chi, Lawal, Bashir, Khedkar, Harshita, Sumitra, Maryam Rachmawati, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2021

mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 Are Druggable Candidates for N-(2,4-Difluorophenyl)-2′,4′-Difluoro-4-Hydroxybiphenyl-3-Carboxamide (NSC765598), With Consequent Anticancer Implicat...

por Lawal, Bashir, Lee, Ching-Yu, Mokgautsi, Ntlotlang, Sumitra, Maryam Rachmawati, Khedkar, Harshita, Wu, Alexander T.H., Huang, Hsu-Shan
Publicado 2021

Preclinical Evaluation of a Novel Small Molecule LCC-21 to Suppress Colorectal Cancer Malignancy by Inhibiting Angiogenic and Metastatic Signatures

por Mokgautsi, Ntlotlang, Kuo, Yu-Cheng, Huang, Yan-Jiun, Chen, Chien-Hsin, Mukhopadhyay, Debabrata, Wu, Alexander T. H., Huang, Hsu-Shan
Publicado 2023

A Preclinical Investigation of GBM-N019 as a Potential Inhibitor of Glioblastoma via Exosomal mTOR/CDK6/STAT3 Signaling

por Wu, Alexander T. H., Huang, Hsu-Shan, Wen, Ya-Ting, Lawal, Bashir, Mokgautsi, Ntlotlang, Huynh, Thanh-Tuan, Hsiao, Michael, Wei, Li
Publicado 2021