Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation

por Chen, Chyi-Ying A., Strouz, Krista, Huang, Kai-Lieh, Shyu, Ann-Bin
Publicado 2020

Inositol hexakisphosphate is required for Integrator function

por Lin, Min-Han, Jensen, Madeline K., Elrod, Nathan D., Huang, Kai-Lieh, Welle, Kevin A., Wagner, Eric J., Tong, Liang
Publicado 2022

Vimentin Is a Novel Anti-Cancer Therapeutic Target; Insights from In Vitro and In Vivo Mice Xenograft Studies

por Lahat, Guy, Zhu, Quan-Sheng, Huang, Kai-Lieh, Wang, Suizhao, Bolshakov, Svetlana, Liu, Jeffery, Torres, Keila, Langley, Robert R., Lazar, Alexander J., Hung, Mien Chie, Lev, Dina
Publicado 2010

Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module

por Albrecht, Todd R, Shevtsov, Sergey P, Wu, Yixuan, Mascibroda, Lauren G, Peart, Natoya J, Huang, Kai-Lieh, Sawyer, Iain A, Tong, Liang, Dundr, Miroslav, Wagner, Eric J
Publicado 2018

The Integrator complex cleaves nascent mRNAs to attenuate transcription

por Tatomer, Deirdre C., Elrod, Nathan D., Liang, Dongming, Xiao, Mei-Sheng, Jiang, Jeffrey Z., Jonathan, Michael, Huang, Kai-Lieh, Wagner, Eric J., Cherry, Sara, Wilusz, Jeremy E.
Publicado 2019

Vimentin is a novel AKT1 target mediating motility and invasion

por Zhu, Quan-Sheng, Rosenblatt, Kevin, Huang, Kai-Lieh, Lahat, Guy, Brobey, Reynolds, Bolshakov, Svetlana, Nguyen, Theresa, Ding, Zhiyong, Belousov, Roman, Bill, Katelynn, Luo, Xuemei, Lazar, Alexander, Dicker, Adam, Mills, Gordon B., Hung, Mien-Chie, Lev, Dina
Publicado 2010

INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex

por Mascibroda, Lauren G., Shboul, Mohammad, Elrod, Nathan D., Colleaux, Laurence, Hamamy, Hanan, Huang, Kai-Lieh, Peart, Natoya, Singh, Moirangthem Kiran, Lee, Hane, Merriman, Barry, Jodoin, Jeanne N., Sitaram, Poojitha, Lee, Laura A., Fathalla, Raja, Al-Rawashdeh, Baeth, Ababneh, Osama, El-Khateeb, Mohammad, Escande-Beillard, Nathalie, Nelson, Stanley F., Wu, Yixuan, Tong, Liang, Kenney, Linda J., Roy, Sudipto, Russell, William K., Amiel, Jeanne, Reversade, Bruno, Wagner, Eric J.
Publicado 2022

Alternative polyadenylation alters protein dosage by switching between intronic and 3′UTR sites

por de Prisco, Nicola, Ford, Caitlin, Elrod, Nathan D., Lee, Winston, Tang, Lauren C., Huang, Kai-Lieh, Lin, Ai, Ji, Ping, Jonnakuti, Venkata S., Boyle, Lia, Cabaj, Maximilian, Botta, Salvatore, Õunap, Katrin, Reinson, Karit, Wojcik, Monica H., Rosenfeld, Jill A., Bi, Weimin, Tveten, Kristian, Prescott, Trine, Gerstner, Thorsten, Schroeder, Audrey, Fong, Chin-To, George-Abraham, Jaya K., Buchanan, Catherine A., Hanson-Khan, Andrea, Bernstein, Jonathan A., Nella, Aikaterini A., Chung, Wendy K., Brandt, Vicky, Jovanovic, Marko, Targoff, Kimara L., Yalamanchili, Hari Krishna, Wagner, Eric J., Gennarino, Vincenzo A.
Publicado 2023