The GPCR–β-arrestin complex allosterically activates C-Raf by binding its amino terminus

por Zang, Yunxiang, Kahsai, Alem W., Pakharukova, Natalia, Huang, Li-yin, Lefkowitz, Robert J.
Publicado 2021

Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin

por Kahsai, Alem W., Shah, Kunal S., Shim, Paul J., Lee, Mason A., Shreiber, Bowie N., Schwalb, Allison M., Zhang, Xingdong, Kwon, Henry Y., Huang, Li-Yin, Soderblom, Erik J., Ahn, Seungkirl, Lefkowitz, Robert J.
Publicado 2023

Structure of active β-arrestin1 bound to a G protein-coupled receptor phosphopeptide

por Shukla, Arun K., Manglik, Aashish, Kruse, Andrew C., Xiao, Kunhong, Reis, Rosana I., Tseng, Wei-Chou, Staus, Dean P., Hilger, Daniel, Uysal, Serdar, Huang, Li-Yin, Paduch, Marcin, Tripathi-Shukla, Prachi, Koide, Akiko, Koide, Shohei, Weis, William I., Kossiakoff, Anthony A., Kobilka, Brian K., Lefkowitz, Robert J.
Publicado 2013

Small-Molecule Positive Allosteric Modulators of the β(2)-Adrenoceptor Isolated from DNA-Encoded Libraries

por Ahn, Seungkirl, Pani, Biswaranjan, Kahsai, Alem W., Olsen, Eva K., Husemoen, Gitte, Vestergaard, Mikkel, Jin, Lei, Zhao, Shuai, Wingler, Laura M., Rambarat, Paula K., Simhal, Rishabh K., Xu, Thomas T., Sun, Lillian D., Shim, Paul J., Staus, Dean P., Huang, Li-Yin, Franch, Thomas, Chen, Xin, Lefkowitz, Robert J.
Publicado 2018

Structure of an Endosomal Signaling GPCR–G Protein–β-arrestin Mega-Complex

por Nguyen, Anthony H., Thomsen, Alex R. B., Cahill, Thomas J., Huang, Rick, Huang, Li-Yin, Marcink, Tara, Clarke, Oliver B., Heissel, Søren, Masoudi, Ali, Ben-Hail, Danya, Samaan, Fadi, Dandey, Venkata P., Tan, Yong Zi, Hong, Chuan, Mahoney, Jacob P., Triest, Sarah, Little, John, Chen, Xin, Sunahara, Roger, Steyaert, Jan, Molina, Henrik, Yu, Zhiheng, des Georges, Amedee, Lefkowitz, Robert J.
Publicado 2019

Visualization of arrestin recruitment by a G Protein-Coupled Receptor

por Shukla, Arun K., Westfield, Gerwin H., Xiao, Kunhong, Reis, Rosana I., Huang, Li-Yin, Tripathi-Shukla, Prachi, Qian, Jiang, Li, Sheng, Blanc, Adi, Oleskie, Austin N., Dosey, Anne M., Su, Min, Liang, Cui-Rong, Gu, Ling-Ling, Shan, Jin-Ming, Chen, Xin, Hanna, Rachel, Choi, Minjung, Yao, Xiao Jie, Klink, Bjoern U., Kahsai, Alem W., Sidhu, Sachdev S., Koide, Shohei, Penczek, Pawel A., Kossiakoff, Anthony A., Jr, Virgil L. Woods, Kobilka, Brian K., Skiniotis, Georgios, Lefkowitz, Robert J.
Publicado 2014