Ig-VAE: Generative modeling of protein structure by direct 3D coordinate generation

por Eguchi, Raphael R., Choe, Christian A., Huang, Po-Ssu
Publicado 2022

An all-atom protein generative model

por Chu, Alexander E., Cheng, Lucy, Nesr, Gina El, Xu, Minkai, Huang, Po-Ssu
Publicado 2023

De Novo Design of a Highly Stable Ovoid TIM Barrel: Unlocking Pocket Shape towards Functional Design

por Chu, Alexander E., Fernandez, Daniel, Liu, Jingjia, Eguchi, Raphael R., Huang, Po-Ssu
Publicado 2022

Control of repeat protein curvature by computational protein design

por Park, Keunwan, Shen, Betty W., Parmeggiani, Fabio, Huang, Po-Ssu, Stoddard, Barry L., Baker, David
Publicado 2015

De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy

por Huang, Po-Ssu, Feldmeier, Kaspar, Parmeggiani, Fabio, Velasco, D. Alejandro Fernandez, Höcker, Birte, Baker, David
Publicado 2015

RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

por Huang, Po-Ssu, Ban, Yih-En Andrew, Richter, Florian, Andre, Ingemar, Vernon, Robert, Schief, William R., Baker, David
Publicado 2011

Protein sequence design with a learned potential

por Anand, Namrata, Eguchi, Raphael, Mathews, Irimpan I., Perez, Carla P., Derry, Alexander, Altman, Russ B., Huang, Po-Ssu
Publicado 2022

Exploring the repeat protein universe through computational protein design

por Brunette, TJ, Parmeggiani, Fabio, Huang, Po-Ssu, Bhabha, Gira, Ekiert, Damian C., Tsutakawa, Susan E., Hura, Greg L., Tainer, John A., Baker, David
Publicado 2015

Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion

por Caldwell, Shane J., Haydon, Ian C., Piperidou, Nikoletta, Huang, Po-Ssu, Bick, Matthew J., Sjöström, H. Sebastian, Hilvert, Donald, Baker, David, Zeymer, Cathleen
Publicado 2020

Interleukin-2 superkines by computational design

por Ren, Junming, Chu, Alexander E., Jude, Kevin M., Picton, Lora K., Kare, Aris J., Su, Leon, Montano Romero, Alejandra, Huang, Po-Ssu, Garcia, K. Christopher
Publicado 2022

Theoretical basis for stabilizing messenger RNA through secondary structure design

por Wayment-Steele, Hannah K., Kim, Do Soon, Choe, Christian A., Nicol, John J., Wellington-Oguri, Roger, Watkins, Andrew M., Sperberg, R. Andres Parra, Huang, Po-Ssu, Participants, Eterna, Das, Rhiju
Publicado 2021

Theoretical basis for stabilizing messenger RNA through secondary structure design

por Wayment-Steele, Hannah K, Kim, Do Soon, Choe, Christian A, Nicol, John J, Wellington-Oguri, Roger, Watkins, Andrew M, Parra Sperberg, R Andres, Huang, Po-Ssu, Participants, Eterna, Das, Rhiju
Publicado 2021

Correction to ‘Theoretical basis for stabilizing messenger RNA through secondary structure design’

por Wayment-Steele, Hannah K, Kim, Do Soon, Choe, Christian A, Nicol, John J, Wellington-Oguri, Roger, Watkins, Andrew M, Parra Sperberg, R Andres, Huang, Po-Ssu, Participants, Eterna, Das, Rhiju
Publicado 2021

Computational design of closely related proteins that adopt two well-defined but structurally divergent folds

por Wei, Kathy Y., Moschidi, Danai, Bick, Matthew J., Nerli, Santrupti, McShan, Andrew C., Carter, Lauren P., Huang, Po-Ssu, Fletcher, Daniel A., Sgourakis, Nikolaos G., Boyken, Scott E., Baker, David
Publicado 2020

A computationally engineered RAS rheostat reveals RAS/ERK signaling dynamics

por Rose, John C., Huang, Po-Ssu, Camp, Nathan D., Ye, Jordan, Leidal, Andrew M., Goreshnik, Inna, Trevillian, Bridget M., Dickinson, Miles S., Cunningham-Bryant, Daniel, Debnath, Jayanta, Baker, David, Wolf-Yadlin, Alejandro, Maly, Dustin J.
Publicado 2016

The molecular basis of chaperone-mediated interleukin 23 assembly control

por Meier, Susanne, Bohnacker, Sina, Klose, Carolin J., Lopez, Abraham, Choe, Christian A., Schmid, Philipp W. N., Bloemeke, Nicolas, Rührnößl, Florian, Haslbeck, Martin, Bieren, Julia Esser-von, Sattler, Michael, Huang, Po-Ssu, Feige, Matthias J.
Publicado 2019

Design of a hyperstable 60-subunit protein icosahedron

por Hsia, Yang, Bale, Jacob B., Gonen, Shane, Shi, Dan, Sheffler, William, Fong, Kimberly K., Nattermann, Una, Xu, Chunfu, Huang, Po-Ssu, Ravichandran, Rashmi, Yi, Sue, Davis, Trisha N., Gonen, Tamir, King, Neil P., Baker, David
Publicado 2016

De novo design of a fluorescence-activating β-barrel

por Dou, Jiayi, Vorobieva, Anastassia A., Sheffler, William, Doyle, Lindsey A., Park, Hahnbeom, Bick, Matthew J., Mao, Binchen, Foight, Glenna W., Lee, Min Yen, Gagnon, Lauren A., Carter, Lauren, Sankaran, Banumathi, Ovchinnikov, Sergey, Marcos, Enrique, Huang, Po-Ssu, Vaughan, Joshua C., Stoddard, Barry L., Baker, David
Publicado 2018

Fully synthetic platform to rapidly generate tetravalent bispecific nanobody–based immunoglobulins

por Misson Mindrebo, Laetitia, Liu, Hejun, Ozorowski, Gabriel, Tran, Quoc, Woehl, Jordan, Khalek, Irene, Smith, Jessica M., Barman, Shawn, Zhao, Fangzhu, Keating, Celina, Limbo, Oliver, Verma, Megan, Liu, Jingjia, Stanfield, Robyn L., Zhu, Xueyong, Turner, Hannah L., Sok, Devin, Huang, Po-Ssu, Burton, Dennis R., Ward, Andrew B., Wilson, Ian A., Jardine, Joseph G.
Publicado 2023

Computational Design of Transmembrane Pores

por Xu, Chunfu, Lu, Peilong, El-Din, Tamer M. Gamal, Pei, Xue Y., Johnson, Matthew C., Uyeda, Atsuko, Bick, Matthew J., Xu, Qi, Jiang, Daohua, Bai, Hua, Reggiano, Gabriella, Hsia, Yang, Brunette, TJ, Dou, Jiayi, Ma, Dan, Lynch, Eric, Boyken, Scott E., Huang, Po-Ssu, Stewart, Lance, DiMaio, Frank, Kollman, Justin M., Luisi, Ben F., Matsuura, Tomoaki, Catterall, William A., Baker, David
Publicado 2020