Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair

por Huang, Shar-yin Naomi, Pommier, Yves
Publicado 2019

Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes

por Saha, Liton Kumar, Saha, Sourav, Yang, Xi, Huang, Shar-yin Naomi, Sun, Yilun, Jo, Ukhyun, Pommier, Yves
Publicado 2023

Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo

por Cho, Jang-Eun, Huang, Shar-yin N., Burgers, Peter M., Shuman, Stewart, Pommier, Yves, Jinks-Robertson, Sue
Publicado 2016

TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

por Huang, Shar-yin N., Murai, Junko, Dalla Rosa, Ilaria, Dexheimer, Thomas S., Naumova, Alena, Gmeiner, William H., Pommier, Yves
Publicado 2013

The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes

por Saha, Sourav, Huang, Shar-yin Naomi, Yang, Xi, Saha, Liton Kumar, Sun, Yilun, Khandagale, Prashant, Jenkins, Lisa M., Pommier, Yves
Publicado 2023

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining

por Kawale, Ajinkya S, Akopiants, Konstantin, Valerie, Kristoffer, Ruis, Brian, Hendrickson, Eric A, Huang, Shar-yin N, Pommier, Yves, Povirk, Lawrence F
Publicado 2018

Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome

por Al Khatib, Iman, Deng, Jingti, Symes, Andrew, Kerr, Marina, Zhang, Hongliang, Huang, Shar-yin Naomi, Pommier, Yves, Khan, Aneal, Shutt, Timothy E.
Publicado 2022

Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes

por Huang, Shar-yin N., Michaels, Stephanie A., Mitchell, Brianna B., Majdalani, Nadim, Vanden Broeck, Arnaud, Canela, Andres, Tse-Dinh, Yuk-Ching, Lamour, Valerie, Pommier, Yves
Publicado 2021

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

por Sun, Yilun, Chen, Jiji, Huang, Shar-yin N., Su, Yijun P., Wang, Wenjie, Agama, Keli, Saha, Sourav, Jenkins, Lisa M., Pascal, John M., Pommier, Yves
Publicado 2021

DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

por Saha, Sourav, Sun, Yilun, Naomi Huang, Shar-yin, Baechler, Simone Andrea, Pongor, Lorinc Sandor, Agama, Keli, Jo, Ukhyun, Zhang, Hongliang, Tse-Dinh, Yuk-Ching, Pommier, Yves
Publicado 2020

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage

por Das, Benu Brata, Huang, Shar-yin N., Murai, Junko, Rehman, Ishita, Amé, Jean-Christophe, Sengupta, Souvik, Das, Subhendu K., Majumdar, Papiya, Zhang, Hongliang, Biard, Denis, Majumder, Hemanta K., Schreiber, Valérie, Pommier, Yves
Publicado 2014

The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)

por Tsuda, Masataka, Terada, Kazuhiro, Ooka, Masato, Kobayashi, Koji, Sasanuma, Hiroyuki, Fujisawa, Ryo, Tsurimoto, Toshiki, Yamamoto, Junpei, Iwai, Shigenori, Kadoda, Kei, Akagawa, Remi, Huang, Shar-Yin Naomi, Pommier, Yves, Sale, Julian E., Takeda, Shunichi, Hirota, Kouji
Publicado 2017

BAMscale: quantification of next-generation sequencing peaks and generation of scaled coverage tracks

por Pongor, Lorinc S., Gross, Jacob M., Vera Alvarez, Roberto, Murai, Junko, Jang, Sang-Min, Zhang, Hongliang, Redon, Christophe, Fu, Haiqing, Huang, Shar-Yin, Thakur, Bhushan, Baris, Adrian, Marino-Ramirez, Leonardo, Landsman, David, Aladjem, Mirit I., Pommier, Yves
Publicado 2020

Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT

por Al Khatib, Iman, Deng, Jingti, Lei, Yuanjiu, Torres-Odio, Sylvia, Rojas, Gladys R, Newman, Laura E, Chung, Brian K, Symes, Andrew, Zhang, Hongliang, Huang, Shar-yin N, Pommier, Yves, Khan, Aneal, Shadel, Gerald S, West, Andrew Phillip, Gibson, William T, Shutt, Timothy E
Publicado 2023

Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex

por Sun, Yilun, Baechler, Simone A., Zhang, Xiaohu, Kumar, Suresh, Factor, Valentina M., Arakawa, Yasuhiro, Chau, Cindy H., Okamoto, Kanako, Parikh, Anup, Walker, Bob, Su, Yijun P., Chen, Jiji, Ting, Tabitha, Huang, Shar-yin N., Beck, Erin, Itkin, Zina, McKnight, Crystal, Xie, Changqing, Roper, Nitin, Nijhawan, Deepak, Figg, William Douglas, Meltzer, Paul S., Yang, James C., Thomas, Craig J., Pommier, Yves
Publicado 2023