Continuous directed evolution of proteins with improved soluble expression

por Wang, Tina, Badran, Ahmed H., Huang, Tony P., Liu, David R.
Publicado 2018

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

por Mok, Beverly Y., Kotrys, Anna V., Raguram, Aditya, Huang, Tony P., Mootha, Vamsi K., Liu, David R.
Publicado 2022

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

por Huang, Tony P., Zhao, Kevin T., Miller, Shannon M., Gaudelli, Nicole M., Oakes, Benjamin L., Fellmann, Christof, Savage, David F., Liu, David R.
Publicado 2019

High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs

por Huang, Tony P., Heins, Zachary J., Miller, Shannon M., Wong, Brandon G., Balivada, Pallavi A., Wang, Tina, Khalil, Ahmad S., Liu, David R.
Publicado 2022

Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors

por Davis, Jessie R., Wang, Xiao, Witte, Isaac P., Huang, Tony P., Levy, Jonathan M., Raguram, Aditya, Banskota, Samagya, Seidah, Nabil G., Musunuru, Kiran, Liu, David R.
Publicado 2022

Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors

por Davis, Jessie R., Wang, Xiao, Witte, Isaac P., Huang, Tony P., Levy, Jonathan M., Raguram, Aditya, Banskota, Samagya, Seidah, Nabil G., Musunuru, Kiran, Liu, David R.
Publicado 2022

Continuous evolution of SpCas9 variants compatible with non-G PAMs

por Miller, Shannon M., Wang, Tina, Randolph, Peyton B., Arbab, Mandana, Shen, Max W., Huang, Tony P., Matuszek, Zaneta, Newby, Gregory A., Rees, Holly A., Liu, David R.
Publicado 2020

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity

por Neugebauer, Monica E., Hsu, Alvin, Arbab, Mandana, Krasnow, Nicholas A., McElroy, Amber N., Pandey, Smriti, Doman, Jordan L., Huang, Tony P., Raguram, Aditya, Banskota, Samagya, Newby, Gregory A., Tolar, Jakub, Osborn, Mark J., Liu, David R.
Publicado 2022