Oncolytic targeting of androgen-sensitive prostate tumor by the respiratory syncytial virus (RSV): consequences of deficient interferon-dependent antiviral defense

por Echchgadda, Ibtissam, Chang, Te-Hung, Sabbah, Ahmed, Bakri, Imad, Ikeno, Yuji, Hubbard, Gene B, Chatterjee, Bandana, Bose, Santanu
Publicado 2011

Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology?

por Ikeno, Yuji, Hubbard, Gene B., Lee, Shuko, Dube, Sara M., Flores, Lisa C., Roman, Madeline G., Bartke, Andrzej
Publicado 2013

Thioredoxin, oxidative stress, cancer and aging

por Flores, Lisa C, Ortiz, Melanie, Dube, Sara, Hubbard, Gene B, Lee, Shuko, Salmon, Adam, Zhang, Yiqiang, Ikeno, Yuji
Publicado 2012

Continuous overexpression of thioredoxin 1 enhances cancer development and does not extend maximum lifespan in male C57BL/6 mice

por Flores, Lisa C., Roman, Madeline G., Cunningham, Geneva M., Cheng, Christie, Dube, Sara, Allen, Colton, Van Remmen, Holly, Hubbard, Gene B., Saunders, Thomas L., Ikeno, Yuji
Publicado 2018

The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas

por Mahlke, Megan A., Cortez, Lisa A., Ortiz, Melanie A., Rodriguez, Marisela, Uchida, Koji, Shigenaga, Mark K., Lee, Shuko, Zhang, Yiquang, Tominaga, Kaoru, Hubbard, Gene B., Ikeno, Yuji
Publicado 2011

Thioredoxin overexpression in mitochondria showed minimum effects on aging and age-related diseases in male C57BL/6 mice

por Roman, Madeline G., Flores, Lisa C., Cunningham, Geneva M., Cheng, Christie, Dube, Sara, Allen, Colton, Van Remmen, Holly, Bai, Yidong, Hubbard, Gene B., Saunders, Thomas L., Ikeno, Yuji
Publicado 2020

Does Reduced IGF-1R Signaling in Igf1r (+/−) Mice Alter Aging?

por Bokov, Alex F., Garg, Neha, Ikeno, Yuji, Thakur, Sachin, Musi, Nicolas, DeFronzo, Ralph A., Zhang, Ning, Erickson, Rebecca C., Gelfond, Jon, Hubbard, Gene B., Adamo, Martin L., Richardson, Arlan
Publicado 2011

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR−/− mice

por List, Edward O., Berryman, Darlene E., Ikeno, Yuji, Hubbard, Gene B., Funk, Kevin, Comisford, Ross, Young, Jonathan A., Stout, Michael B., Tchkonia, Tamar, Masternak, Michal M., Bartke, Andrzej, Kirkland, James L., Miller, Richard A., Kopchick, John J.
Publicado 2015

Reductions in serum IGF-1 during aging impair health span

por Gong, Zhenwei, Kennedy, Oran, Sun, Hui, Wu, YingJie, Williams, Garry A, Klein, Laura, Cardoso, Luis, Matheny, Ronald W, Hubbard, Gene B, Ikeno, Yuji, Farrar, Roger P, Schaffler, Mitchell B, Adamo, Martin L, Muzumdar, Radhika H, Yakar, Shoshana
Publicado 2014

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

por Mao, Kai, Quipildor, Gabriela Farias, Tabrizian, Tahmineh, Novaj, Ardijana, Guan, Fangxia, Walters, Ryan O., Delahaye, Fabien, Hubbard, Gene B., Ikeno, Yuji, Ejima, Keisuke, Li, Peng, Allison, David B., Salimi-Moosavi, Hossein, Beltran, Pedro J., Cohen, Pinchas, Barzilai, Nir, Huffman, Derek M.
Publicado 2018

Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas D...

por Sathler-Avelar, Renato, Vitelli-Avelar, Danielle Marquete, Mattoso-Barbosa, Armanda Moreira, Perdigão-de-Oliveira, Marcelo, Costa, Ronaldo Peres, Elói-Santos, Silvana Maria, Gomes, Matheus de Souza, do Amaral, Laurence Rodrigues, Teixeira-Carvalho, Andréa, Martins-Filho, Olindo Assis, Dick, Edward J., Hubbard, Gene B., VandeBerg, Jane F., VandeBerg, John L.
Publicado 2016

Cynomolgus macaques naturally infected with Trypanosoma cruzi-I exhibit an overall mixed pro-inflammatory/modulated cytokine signature characteristic of human Chagas disease

por Vitelli-Avelar, Danielle Marquete, Sathler-Avelar, Renato, Mattoso-Barbosa, Armanda Moreira, Gouin, Nicolas, Perdigão-de-Oliveira, Marcelo, Valério-dos-Reis, Leydiane, Costa, Ronaldo Peres, Elói-Santos, Silvana Maria, Gomes, Matheus de Souza, do Amaral, Laurence Rodrigues, Teixeira-Carvalho, Andréa, Martins-Filho, Olindo Assis, Dick, Edward J., Hubbard, Gene B., VandeBerg, Jane F., VandeBerg, John L.
Publicado 2017

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

por Zhu, Yi, Tchkonia, Tamara, Pirtskhalava, Tamar, Gower, Adam C, Ding, Husheng, Giorgadze, Nino, Palmer, Allyson K, Ikeno, Yuji, Hubbard, Gene B, Lenburg, Marc, O’Hara, Steven P, LaRusso, Nicholas F, Miller, Jordan D, Roos, Carolyn M, Verzosa, Grace C, LeBrasseur, Nathan K, Wren, Jonathan D, Farr, Joshua N, Khosla, Sundeep, Stout, Michael B, McGowan, Sara J, Fuhrmann-Stroissnigg, Heike, Gurkar, Aditi U, Zhao, Jing, Colangelo, Debora, Dorronsoro, Akaitz, Ling, Yuan Yuan, Barghouthy, Amira S, Navarro, Diana C, Sano, Tokio, Robbins, Paul D, Niedernhofer, Laura J, Kirkland, James L
Publicado 2015

Senolytics Improve Physical Function and Increase Lifespan in Old Age

por Xu, Ming, Pirtskhalava, Tamar, Farr, Joshua N., Weigand, Bettina M., Palmer, Allyson K., Weivoda, Megan M., Inman, Christina L., Ogrodnik, Mikolaj B., Hachfeld, Christine M., Fraser, Daniel G., Onken, Jennifer L., Johnson, Kurt O., Verzosa, Grace C., Langhi, Larissa G. P., Weigl, Moritz, Giorgadze, Nino, LeBrasseur, Nathan K., Miller, Jordan D., Jurk, Diana, Singh, Ravinder J., Allison, David B., Ejima, Keisuke, Hubbard, Gene B., Ikeno, Yuji, Cubro, Hajrunisa, Garovic, Vesna D., Hou, Xiaonan, Weroha, SJ, Robbins, Paul D., Niedernhofer, Laura J., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L.
Publicado 2018