SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands

por Huber, Sylwia, Casagrande, Fabio, Hug, Melanie N., Wang, Lisha, Heine, Philipp, Kummer, Lutz, Plückthun, Andreas, Hennig, Michael
Publicado 2017

Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans

por Dangy, Jean-Pierre, Scherr, Nicole, Gersbach, Philipp, Hug, Melanie N., Bieri, Raphael, Bomio, Claudio, Li, Jun, Huber, Sylwia, Altmann, Karl-Heinz, Pluschke, Gerd
Publicado 2016

Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain

por Richter, Kirsten, Rufer, Arne C., Muller, Magali, Burger, Dominique, Casagrande, Fabio, Grossenbacher, Tabea, Huber, Sylwia, Hug, Melanie N., Koldewey, Philipp, D'Osualdo, Andrea, Schlatter, Daniel, Stoll, Theodor, Rudolph, Markus G.
Publicado 2020

Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies

por Moors, Tim E., Mona, Daniel, Luehe, Stefan, Duran-Pacheco, Gonzalo, Spycher, Liz, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N., Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Dernick, Gregor, van de Berg, Wilma D. J., Britschgi, Markus
Publicado 2022

Synthetic single domain antibodies for the conformational trapping of membrane proteins

por Zimmermann, Iwan, Egloff, Pascal, Hutter, Cedric AJ, Arnold, Fabian M, Stohler, Peter, Bocquet, Nicolas, Hug, Melanie N, Huber, Sylwia, Siegrist, Martin, Hetemann, Lisa, Gera, Jennifer, Gmür, Samira, Spies, Peter, Gygax, Daniel, Geertsma, Eric R, Dawson, Roger JP, Seeger, Markus A
Publicado 2018

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy

por Moors, Tim E., Maat, Christina A., Niedieker, Daniel, Mona, Daniel, Petersen, Dennis, Timmermans-Huisman, Evelien, Kole, Jeroen, El-Mashtoly, Samir F., Spycher, Liz, Zago, Wagner, Barbour, Robin, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N., Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Geurts, Jeroen J. G., Gerwert, Klaus, Britschgi, Markus, van de Berg, Wilma D. J.
Publicado 2021

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

por Sivaramakrishnan, Manaswini, McCarthy, Kathleen D., Campagne, Sébastien, Huber, Sylwia, Meier, Sonja, Augustin, Angélique, Heckel, Tobias, Meistermann, Hélène, Hug, Melanie N., Birrer, Pascale, Moursy, Ahmed, Khawaja, Sarah, Schmucki, Roland, Berntenis, Nikos, Giroud, Nicolas, Golling, Sabrina, Tzouros, Manuel, Banfai, Balazs, Duran-Pacheco, Gonzalo, Lamerz, Jens, Hsiu Liu, Ying, Luebbers, Thomas, Ratni, Hasane, Ebeling, Martin, Cléry, Antoine, Paushkin, Sergey, Krainer, Adrian R., Allain, Frédéric H.-T., Metzger, Friedrich
Publicado 2017

DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome

por Richter, Hans, Satz, Alexander L., Bedoucha, Marc, Buettelmann, Bernd, Petersen, Ann C., Harmeier, Anja, Hermosilla, Ricardo, Hochstrasser, Remo, Burger, Dominique, Gsell, Bernard, Gasser, Rodolfo, Huber, Sylwia, Hug, Melanie N., Kocer, Buelent, Kuhn, Bernd, Ritter, Martin, Rudolph, Markus G., Weibel, Franziska, Molina-David, Judith, Kim, Jin-Ju, Santos, Javier Varona, Stihle, Martine, Georges, Guy J., Bonfil, R. Daniel, Fridman, Rafael, Uhles, Sabine, Moll, Solange, Faul, Christian, Fornoni, Alessia, Prunotto, Marco
Publicado 2018