Recruitment of UvrBC complexes to UV-induced damage in the absence of UvrA increases cell survival

por Springall, Luke, Hughes, Craig D, Simons, Michelle, Azinas, Stavros, Van Houten, Bennett, Kad, Neil M
Publicado 2018

Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes

por Hughes, Craig D., Wang, Hong, Ghodke, Harshad, Simons, Michelle, Towheed, Atif, Peng, Ye, Van Houten, Bennett, Kad, Neil M.
Publicado 2013

Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein

por Iljina, Marija, Tosatto, Laura, Choi, Minee L., Sang, Jason C., Ye, Yu, Hughes, Craig D., Bryant, Clare E., Gandhi, Sonia, Klenerman, David
Publicado 2016

Directly interrogating single quantum dot labelled UvrA(2) molecules on DNA tightropes using an optically trapped nanoprobe

por Simons, Michelle, Pollard, Mark R., Hughes, Craig D., Ward, Andrew D., Van Houten, Bennett, Towrie, Mike, Botchway, Stan W., Parker, Anthony W., Kad, Neil M.
Publicado 2015

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

por Hughes, Craig D., Choi, Minee L., Ryten, Mina, Hopkins, Lee, Drews, Anna, Botía, Juan A., Iljina, Maria, Rodrigues, Margarida, Gagliano, Sarah A., Gandhi, Sonia, Bryant, Clare, Klenerman, David
Publicado 2018

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

por Angelova, Plamena R., Choi, Minee L., Berezhnov, Alexey V., Horrocks, Mathew H., Hughes, Craig D., De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S., Kunath, Tilo, Devine, Michael J., Gissen, Paul, Shchepinov, Mikhail S., Sylantyev, Sergiy, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Publicado 2020

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

por Iljina, Marija, Hong, Liu, Horrocks, Mathew H., Ludtmann, Marthe H., Choi, Minee L., Hughes, Craig D., Ruggeri, Francesco S., Guilliams, Tim, Buell, Alexander K., Lee, Ji-Eun, Gandhi, Sonia, Lee, Steven F., Bryant, Clare E., Vendruscolo, Michele, Knowles, Tuomas P. J., Dobson, Christopher M., De Genst, Erwin, Klenerman, David
Publicado 2017