Multi Locus View: an extensible web-based tool for the analysis of genomic data.

por Sergeant, Martin J., Hughes, Jim R., Hentges, Lance, Lunter, Gerton, Downes, Damien J., Taylor, Stephen
Publicado 2021

Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C

por Oudelaar, A. Marieke, Davies, James O.J., Downes, Damien J., Higgs, Douglas R., Hughes, Jim R.
Publicado 2017

LanceOtron: a deep learning peak caller for genome sequencing experiments

por Hentges, Lance D, Sergeant, Martin J, Cole, Christopher B, Downes, Damien J, Hughes, Jim R, Taylor, Stephen
Publicado 2022

Between form and function: the complexity of genome folding

por Oudelaar, A. Marieke, Hanssen, Lars L.P., Hardison, Ross C., Kassouf, Mira T., Hughes, Jim R., Higgs, Douglas R.
Publicado 2017

Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints

por Schwessinger, Ron, Suciu, Maria C., McGowan, Simon J., Telenius, Jelena, Taylor, Stephen, Higgs, Doug R., Hughes, Jim R.
Publicado 2017

High-Throughput Genotyping of CRISPR/Cas Edited Cells in 96-Well Plates

por Nussbaum, Lea, Telenius, Jelena M., Hill, Stephanie, Hirschfeld, Priscila P., Suciu, Maria C., Downes, Damien J., Hughes, Jim R.
Publicado 2018

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus

por Oudelaar, A. Marieke, Harrold, Caroline L., Hanssen, Lars L. P., Telenius, Jelena M., Higgs, Douglas R., Hughes, Jim R.
Publicado 2019

Predicting the three-dimensional folding of cis-regulatory regions in mammalian genomes using bioinformatic data and polymer models

por Brackley, Chris A., Brown, Jill M., Waithe, Dominic, Babbs, Christian, Davies, James, Hughes, Jim R., Buckle, Veronica J., Marenduzzo, Davide
Publicado 2016

Multiplexed analysis of chromosome conformation at vastly improved sensitivity

por Davies, James O.J., Telenius, Jelena M., McGowan, Simon, Roberts, Nigel A., Taylor, Stephen, Higgs, Douglas R., Hughes, Jim R.
Publicado 2015

Capture‐C reveals preformed chromatin interactions between HIF‐binding sites and distant promoters

por Platt, James L, Salama, Rafik, Smythies, James, Choudhry, Hani, Davies, James OJ, Hughes, Jim R, Ratcliffe, Peter J, Mole, David R
Publicado 2016

DeepC: predicting 3D genome folding using megabase-scale transfer learning

por Schwessinger, Ron, Gosden, Matthew, Downes, Damien, Brown, Richard C, Oudelaar, A. Marieke, Telenius, Jelena, Teh, Yee Whye, Lunter, Gerton, Hughes, Jim R.
Publicado 2020

Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells

por Torres, Jason M., Sun, Han, Nylander, Vibe, Downes, Damien J., van de Bunt, Martijn, McCarthy, Mark I., Hughes, Jim R., Gloyn, Anna L.
Publicado 2023

Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo

por Simon, Claire S., Downes, Damien J., Gosden, Matthew E., Telenius, Jelena, Higgs, Douglas R., Hughes, Jim R., Costello, Ita, Bikoff, Elizabeth K., Robertson, Elizabeth J.
Publicado 2017

Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells

por Pavlaki, Ioanna, Shapiro, Michael, Pisignano, Giuseppina, Jones, Stephanie M. E., Telenius, Jelena, Muñoz-Descalzo, Silvia, Williams, Robert J., Hughes, Jim R., Vance, Keith W.
Publicado 2022

Causes and Consequences of Chromatin Variation between Inbred Mice

por Hosseini, Mona, Goodstadt, Leo, Hughes, Jim R., Kowalczyk, Monika S., de Gobbi, Marco, Otto, Georg W., Copley, Richard R., Mott, Richard, Higgs, Douglas R., Flint, Jonathan
Publicado 2013

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes

por Voon, Hsiao P.J., Hughes, Jim R., Rode, Christina, De La Rosa-Velázquez, Inti A., Jenuwein, Thomas, Feil, Robert, Higgs, Douglas R., Gibbons, Richard J.
Publicado 2015

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation

por Godfrey, Laura, Kerry, Jon, Thorne, Ross, Repapi, Emmanouela, Davies, James O.J., Tapia, Marta, Ballabio, Erica, Hughes, Jim R., Geng, Huimin, Konopleva, Marina, Milne, Thomas A.
Publicado 2017

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker

por Bozhilov, Yavor K., Downes, Damien J., Telenius, Jelena, Marieke Oudelaar, A., Olivier, Emmanuel N., Mountford, Joanne C., Hughes, Jim R., Gibbons, Richard J., Higgs, Douglas R.
Publicado 2021

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element

por Huang, Peng, Keller, Cheryl A., Giardine, Belinda, Grevet, Jeremy D., Davies, James O.J., Hughes, Jim R., Kurita, Ryo, Nakamura, Yukio, Hardison, Ross C., Blobel, Gerd A.
Publicado 2017

Capture-C: A modular and flexible approach for high-resolution chromosome conformation capture

por Downes, Damien J., Smith, Alastair L., Karpinska, Magdalena A., Velychko, Taras, Rue-Albrecht, Kevin, Sims, David, Milne, Thomas A., Davies, James O.J., Oudelaar, A. Marieke, Hughes, Jim R.
Publicado 2022