Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils

por Hughes, Michael P., Goldschmidt, Lukasz, Eisenberg, David S.
Publicado 2021

Rapid assessment of early biophysical changes in K562 cells during apoptosis determined using dielectrophoresis

por Chin, Sue, Hughes, Michael P, Coley, Helen M, Labeed, Fatima H
Publicado 2006

Applications of dielectrophoretic/electro-hydrodynamic “zipper” electrodes for detection of biological nanoparticles

por Hübner, Yvonne, Hoettges, Kai F, McDonnell, Martin B, Carter, Michael J, Hughes, Michael P
Publicado 2007

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta

por Jiang, Lin, Liu, Cong, Leibly, David, Landau, Meytal, Zhao, Minglei, Hughes, Michael P, Eisenberg, David S
Publicado 2013

Correction: Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta

por Jiang, Lin, Liu, Cong, Leibly, David, Landau, Meytal, Zhao, Minglei, Hughes, Michael P, Eisenberg, David S
Publicado 2013

Bioinformatic identification of previously unrecognized amyloidogenic proteins

por Rosenberg, Gregory M., Murray, Kevin A., Salwinski, Lukasz, Hughes, Michael P., Abskharon, Romany, Eisenberg, David S.
Publicado 2022

Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model

por Rocha-Ferreira, Eridan, Rudge, Brogan, Hughes, Michael P., Rahim, Ahad A., Hristova, Mariya, Robertson, Nicola J.
Publicado 2016

CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid

por Lu, Jiahui, Cao, Qin, Hughes, Michael P., Sawaya, Michael R., Boyer, David R., Cascio, Duilio, Eisenberg, David S.
Publicado 2020

Systemic AAV9 gene therapy using the synapsin I promoter rescues a mouse model of neuronopathic Gaucher disease but with limited cross-correction potential to astrocytes

por Massaro, Giulia, Hughes, Michael P, Whaler, Sammie M, Wallom, Kerri-Lee, Priestman, David A, Platt, Frances M, Waddington, Simon N, Rahim, Ahad A
Publicado 2020

Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies

por Murray, Kevin A., Hughes, Michael P., Hu, Carolyn J., Sawaya, Michael R., Salwinski, Lukasz, Pan, Hope, French, Samuel W., Seidler, Paul M., Eisenberg, David S.
Publicado 2022

Atomic Structures of Segments from TDP-43 LCD and insight into Reversible and Pathogenic Aggregation

por Guenther, Elizabeth L., Cao, Qin, Trinh, Hamilton, Lu, Jiahui, Sawaya, Michael R., Cascio, Duilio, Boyer, David R., Rodriguez, Jose A., Hughes, Michael P., Eisenberg, David S.
Publicado 2018

Biophysical Characteristics Reveal Neural Stem Cell Differentiation Potential

por Labeed, Fatima H., Lu, Jente, Mulhall, Hayley J., Marchenko, Steve A., Hoettges, Kai F., Estrada, Laura C., Lee, Abraham P., Hughes, Michael P., Flanagan, Lisa A.
Publicado 2011

AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann–Pick type C1 disease

por Hughes, Michael P, Smith, Dave A, Morris, Lauren, Fletcher, Claire, Colaco, Alexandria, Huebecker, Mylene, Tordo, Julie, Palomar, Nuria, Massaro, Giulia, Henckaerts, Els, Waddington, Simon N, Platt, Frances M, Rahim, Ahad A
Publicado 2018

Epilepsy Gene Therapy Using an Engineered Potassium Channel

por Snowball, Albert, Chabrol, Elodie, Wykes, Robert C., Shekh-Ahmad, Tawfeeq, Cornford, Jonathan H., Lieb, Andreas, Hughes, Michael P., Massaro, Giulia, Rahim, Ahad A., Hashemi, Kevan S., Kullmann, Dimitri M., Walker, Matthew C., Schorge, Stephanie
Publicado 2019

Perinatal systemic gene delivery using adeno-associated viral vectors

por Karda, Rajvinder, Buckley, Suzanne M. K., Mattar, Citra N., Ng, Joanne, Massaro, Giulia, Hughes, Michael P., Kurian, Manju A., Baruteau, Julien, Gissen, Paul, Chan, Jerry K. Y., Bacchelli, Chiara, Waddington, Simon N., Rahim, Ahad A.
Publicado 2014

A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins

por Kamal, Muntasir, Tokmakjian, Levon, Knox, Jessica, Mastrangelo, Peter, Ji, Jingxiu, Cai, Hao, Wojciechowski, Jakub W, Hughes, Michael P, Takács, Kristóf, Chu, Xiaoquan, Pei, Jianfeng, Grolmusz, Vince, Kotulska, Malgorzata, Forman-Kay, Julie Deborah, Roy, Peter J
Publicado 2022

Ten–Second Electrophysiology: Evaluation of the 3DEP Platform for high-speed, high-accuracy cell analysis

por Hoettges, Kai F., Henslee, Erin A., Torcal Serrano, Ruth M., Jabr, Rita I., Abdallat, Rula G., Beale, Andrew D., Waheed, Abdul, Camelliti, Patrizia, Fry, Christopher H., van der Veen, Daan R., Labeed, Fatima H., Hughes, Michael P.
Publicado 2019

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle

por Vogler, Thomas O., Wheeler, Joshua R., Nguyen, Eric D., Hughes, Michael P., Britson, Kyla A., Lester, Evan, Rao, Bhalchandra, Dalla Betta, Nicole, Whitney, Oscar N., Ewachiw, Theodore E., Gomes, Edward, Shorter, James, Lloyd, Thomas E., Eisenberg, David S., Taylor, J. Paul, Johnson, Aaron M., Olwin, Bradley B., Parker, Roy
Publicado 2018

Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer

por Baruteau, Julien, Perocheau, Dany P., Hanley, Joanna, Lorvellec, Maëlle, Rocha-Ferreira, Eridan, Karda, Rajvinder, Ng, Joanne, Suff, Natalie, Diaz, Juan Antinao, Rahim, Ahad A., Hughes, Michael P., Banushi, Blerida, Prunty, Helen, Hristova, Mariya, Ridout, Deborah A., Virasami, Alex, Heales, Simon, Howe, Stewen J., Buckley, Suzanne M. K., Mills, Philippa B., Gissen, Paul, Waddington, Simon N.
Publicado 2018

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

por Yang, Zemin, Johnson, Bryan A., Meliopoulos, Victoria A., Ju, Xiaohui, Zhang, Peipei, Hughes, Michael P., Wu, Jinjun, Koreski, Kaitlin P., Chang, Ti-Cheng, Wu, Gang, Hixon, Jeff, Duffner, Jay, Wong, Kathy, Lemieux, Rene, Lokugamage, Kumari G., Alvardo, Rojelio E., Crocquet-Valdes, Patricia A., Walker, David H., Plante, Kenneth S., Plante, Jessica A., Weaver, Scott C., Kim, Hong Joo, Meyers, Rachel, Schultz-Cherry, Stacey, Ding, Qiang, Menachery, Vineet D., Taylor, J. Paul
Publicado 2023