Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders

por Hughes, Scott J., Ciulli, Alessio
Publicado 2017

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

por Girardini, Miriam, Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Ciulli, Alessio
Publicado 2019

Structure‐Based Design of a Macrocyclic PROTAC

por Testa, Andrea, Hughes, Scott J., Lucas, Xavier, Wright, Jane E., Ciulli, Alessio
Publicado 2019

Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs

por Hughes, Scott J., Antoshchenko, Tetyana, Chen, Yun, Lu, Hua, Pizarro, Juan C., Park, Hee-Won
Publicado 2016

Correction: Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs

por Hughes, Scott J, Antoshchenko, Tetyana, Chen, Yun, Lu, Hua, Pizarro, Juan C, Park, Hee-Won
Publicado 2016

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate

por Roy, Michael J., Winkler, Sandra, Hughes, Scott J., Whitworth, Claire, Galant, Michael, Farnaby, William, Rumpel, Klaus, Ciulli, Alessio
Publicado 2019

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

por Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Chen, Wenzhang, Lamont, Douglas J., Rocha, Sonia, Alessi, Dario R., Romeo, Roberto, Ciulli, Alessio
Publicado 2017

Understanding and Improving the Membrane Permeability of VH032-Based PROTACs

por Klein, Victoria G., Townsend, Chad E., Testa, Andrea, Zengerle, Michael, Maniaci, Chiara, Hughes, Scott J., Chan, Kwok-Ho, Ciulli, Alessio, Lokey, R. Scott
Publicado 2020

Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

por Hanzl, Alexander, Casement, Ryan, Imrichova, Hana, Hughes, Scott J., Barone, Eleonora, Testa, Andrea, Bauer, Sophie, Wright, Jane, Brand, Matthias, Ciulli, Alessio, Winter, Georg E.
Publicado 2023

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual...

por Zoppi, Vittoria, Hughes, Scott J., Maniaci, Chiara, Testa, Andrea, Gmaschitz, Teresa, Wieshofer, Corinna, Koegl, Manfred, Riching, Kristin M., Daniels, Danette L., Spallarossa, Andrea, Ciulli, Alessio
Publicado 2018

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

por Imaide, Satomi, Riching, Kristin M., Makukhin, Nikolai, Vetma, Vesna, Whitworth, Claire, Hughes, Scott J., Trainor, Nicole, Mahan, Sarah D., Murphy, Nancy, Cowan, Angus D., Chan, Kwok-Ho, Craigon, Conner, Testa, Andrea, Maniaci, Chiara, Urh, Marjeta, Daniels, Danette L., Ciulli, Alessio
Publicado 2021