Results of a proof of concept, double-blind, randomized trial of a second generation antisense oligonucleotide targeting high-sensitivity C-reactive protein (hs-CRP) in rheumatoid...

por Warren, Marshelle S, Hughes, Steven G, Singleton, Walter, Yamashita, Mason, Genovese, Mark C
Publicado 2015

Lack of QT Prolongation for 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlle...

por Yu, Rosie Z., Gunawan, Rudy, Geary, Richard S., Hughes, Steven G., Henry, Scott P., Wang, Yanfeng
Publicado 2017

N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels

por Alexander, Veronica J, Xia, Shuting, Hurh, Eunju, Hughes, Steven G, O’Dea, Louis, Geary, Richard S, Witztum, Joseph L, Tsimikas, Sotirios
Publicado 2019

An Integrated Safety Analysis of Infants and Children with Symptomatic Spinal Muscular Atrophy (SMA) Treated with Nusinersen in Seven Clinical Trials

por Darras, Basil T., Farrar, Michelle A., Mercuri, Eugenio, Finkel, Richard S., Foster, Richard, Hughes, Steven G., Bhan, Ishir, Farwell, Wildon, Gheuens, Sarah
Publicado 2019

The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans

por Crooke, Stanley T., Baker, Brenda F., Pham, Nguyen C., Hughes, Steven G., Kwoh, T. Jesse, Cai, Danlin, Tsimikas, Sotirios, Geary, Richard S., Bhanot, Sanjay
Publicado 2018

The Effects of 2′-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials

por Crooke, Stanley T., Baker, Brenda F., Witztum, Joseph L., Kwoh, T. Jesse, Pham, Nguyen C., Salgado, Nelson, McEvoy, Bradley W., Cheng, Wei, Hughes, Steven G., Bhanot, Sanjay, Geary, Richard S.
Publicado 2017

IONIS-PKK(Rx) a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production

por Ferrone, Jason D., Bhattacharjee, Gourab, Revenko, Alexey S., Zanardi, Thomas A., Warren, Marshelle S., Derosier, Frederick J., Viney, Nicholas J., Pham, Nguyen C., Kaeser, Gwendolyn E., Baker, Brenda F., Schneider, Eugene, Hughes, Steven G., Monia, Brett P., MacLeod, A. Robert
Publicado 2019

Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine

por Ong, Eugenia Z., Yee, Jia Xin, Ooi, Justin S. G., Syenina, Ayesa, de Alwis, Ruklanthi, Chen, Shiwei, Sim, Jean X. Y., Kalimuddin, Shirin, Leong, Yan Shan, Chan, Yvonne F. Z., Sekulovich, Rose, Sullivan, Brian M., Lindert, Kelly, Sullivan, Sean B., Chivukula, Pad, Hughes, Steven G., Low, Jenny G., Ooi, Eng Eong, Chan, Kuan Rong
Publicado 2022

Inotersen preserves or improves quality of life in hereditary transthyretin amyloidosis

por Coelho, Teresa, Yarlas, Aaron, Waddington-Cruz, Marcia, White, Michelle K., Sikora Kessler, Asia, Lovley, Andrew, Pollock, Michael, Guthrie, Spencer, Ackermann, Elizabeth J., Hughes, Steven G., Karam, Chafic, Khella, Sami, Gertz, Morie, Merlini, Giampaolo, Obici, Laura, Schmidt, Hartmut H., Polydefkis, Michael, Dyck, P. James B., Brannagan III, Thomas H., Conceição, Isabel, Benson, Merrill D., Berk, John L.
Publicado 2019

A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine

por Low, Jenny G., de Alwis, Ruklanthi, Chen, Shiwei, Kalimuddin, Shirin, Leong, Yan Shan, Mah, Tania Ken Lin, Yuen, Natalene, Tan, Hwee Cheng, Zhang, Summer L., Sim, Jean X. Y., Chan, Yvonne F. Z., Syenina, Ayesa, Yee, Jia Xin, Ong, Eugenia Z., Sekulovich, Rose, Sullivan, Brian B., Lindert, Kelly, Sullivan, Sean M., Chivukula, Pad, Hughes, Steven G., Ooi, Eng Eong
Publicado 2022

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial.

por Reilley, Matthew J., McCoon, Patricia, Cook, Carl, Lyne, Paul, Kurzrock, Razelle, Kim, Youngsoo, Woessner, Richard, Younes, Anas, Nemunaitis, John, Fowler, Nathan, Curran, Michael, Liu, Qinying, Zhou, Tianyuan, Schmidt, Joanna, Jo, Minji, Lee, Samantha J., Yamashita, Mason, Hughes, Steven G., Fayad, Luis, Piha-Paul, Sarina, Nadella, Murali V. P., Xiao, Xiaokun, Hsu, Jeff, Revenko, Alexey, Monia, Brett P., MacLeod, A. Robert, Hong, David S.
Publicado 2018