Cell‐level systems biology model to study inflammatory bowel diseases and their treatment options

por Stübler, Sabine, Kloft, Charlotte, Huisinga, Wilhelm
Publicado 2023

Drug-Class Specific Impact of Antivirals on the Reproductive Capacity of HIV

por von Kleist, Max, Menz, Stephan, Huisinga, Wilhelm
Publicado 2010

Deriving mechanism‐based pharmacodynamic models by reducing quantitative systems pharmacology models: An application to warfarin

por Falkenhagen, Undine, Knöchel, Jane, Kloft, Charlotte, Huisinga, Wilhelm
Publicado 2023

Quantifying uncertainty, variability and likelihood for ordinary differential equation models

por Weiße, Andrea Y, Middleton, Richard H, Huisinga, Wilhelm
Publicado 2010

Predicting the F(ab)-mediated effect of monoclonal antibodies in vivo by combining cell-level kinetic and pharmacokinetic modelling

por Krippendorff, Ben-Fillippo, Oyarzún, Diego A., Huisinga, Wilhelm
Publicado 2012

Nonparametric goodness‐of‐fit testing for parametric covariate models in pharmacometric analyses

por Hartung, Niklas, Wahl, Martin, Rastogi, Abhishake, Huisinga, Wilhelm
Publicado 2021

Nonlinear pharmacokinetics of therapeutic proteins resulting from receptor mediated endocytosis

por Krippendorff, Ben-Fillippo, Kuester, Katharina, Kloft, Charlotte, Huisinga, Wilhelm
Publicado 2009

Estimating HIV-1 Fitness Characteristics from Cross-Sectional Genotype Data

por Gopalakrishnan, Sathej, Montazeri, Hesam, Menz, Stephan, Beerenwinkel, Niko, Huisinga, Wilhelm
Publicado 2014

Physiology-based toxicokinetic modelling of aluminium in rat and man

por Hethey, Christoph, Hartung, Niklas, Wangorsch, Gaby, Weisser, Karin, Huisinga, Wilhelm
Publicado 2021

Bayesian Data Assimilation to Support Informed Decision Making in Individualized Chemotherapy

por Maier, Corinna, Hartung, Niklas, de Wiljes, Jana, Kloft, Charlotte, Huisinga, Wilhelm
Publicado 2020

Reinforcement learning and Bayesian data assimilation for model‐informed precision dosing in oncology

por Maier, Corinna, Hartung, Niklas, Kloft, Charlotte, Huisinga, Wilhelm, de Wiljes, Jana
Publicado 2021

A continued learning approach for model‐informed precision dosing: Updating models in clinical practice

por Maier, Corinna, de Wiljes, Jana, Hartung, Niklas, Kloft, Charlotte, Huisinga, Wilhelm
Publicado 2021

Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data

por Kluwe, Franziska, Michelet, Robin, Huisinga, Wilhelm, Zeitlinger, Markus, Mikus, Gerd, Kloft, Charlotte
Publicado 2023

HIV Quasispecies Dynamics during Pro-Active Treatment Switching: Impact on Multi-Drug Resistance and Resistance Archiving in Latent Reservoirs

por von Kleist, Max, Menz, Stephan, Stocker, Hartmut, Arasteh, Keikawus, Schütte, Christof, Huisinga, Wilhelm
Publicado 2011

Semimechanistic Clearance Models of Oncology Biotherapeutics and Impact of Study Design: Cetuximab as a Case Study

por Grisic, Ana‐Marija, Khandelwal, Akash, Bertolino, Mauro, Huisinga, Wilhelm, Girard, Pascal, Kloft, Charlotte
Publicado 2020

Analysis of protrusion dynamics in amoeboid cell motility by means of regularized contour flows

por Schindler, Daniel, Moldenhawer, Ted, Stange, Maike, Lepro, Valentino, Beta, Carsten, Holschneider, Matthias, Huisinga, Wilhelm
Publicado 2021

Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Response Exemplified by Levofloxacin

por Busse, David, Schaeftlein, André, Solms, Alexander, Ilia, Luis, Michelet, Robin, Zeitlinger, Markus, Huisinga, Wilhelm, Kloft, Charlotte
Publicado 2021

Spontaneous transitions between amoeboid and keratocyte-like modes of migration

por Moldenhawer, Ted, Moreno, Eduardo, Schindler, Daniel, Flemming, Sven, Holschneider, Matthias, Huisinga, Wilhelm, Alonso, Sergio, Beta, Carsten
Publicado 2022

Exploring Dried Blood Spot Cortisol Concentrations as an Alternative for Monitoring Pediatric Adrenal Insufficiency Patients: A Model-Based Analysis

por Stachanow, Viktoria, Neumann, Uta, Blankenstein, Oliver, Bindellini, Davide, Melin, Johanna, Ross, Richard, Whitaker, Martin J., Huisinga, Wilhelm, Michelet, Robin, Kloft, Charlotte
Publicado 2022

A prognostic baseline blood biomarker and tumor growth kinetics integrated model in paclitaxel/platinum treated advanced non‐small cell lung cancer patients

por Ojara, Francis Williams, Henrich, Andrea, Frances, Nicolas, Nassar, Yomna M., Huisinga, Wilhelm, Hartung, Niklas, Geiger, Kimberly, Holdenrieder, Stefan, Joerger, Markus, Kloft, Charlotte
Publicado 2023