Autologous T-cell therapy based on a lentiviral vector expressing long antisense RNA targeted against HIV-1 env gene influences HIV replication and evolution in vivo

por Pasternak, Alexander, Korokhov, Nikolay, Berkhout, Ben, Lukashov, Vladimir, Humeau, Laurent
Publicado 2013

Development of a Low Bias Method for Characterizing Viral Populations Using Next Generation Sequencing Technology

por Willerth, Stephanie M., Pedro, Hélder A. M., Pachter, Lior, Humeau, Laurent M., Arkin, Adam P., Schaffer, David V.
Publicado 2010

Characterization of guinea pig T cell responses elicited after EP-assisted delivery of DNA vaccines to the skin

por Schultheis, Katherine, Schaefer, Hubert, Yung, Bryan S., Oh, Janet, Muthumani, Karuppiah, Humeau, Laurent, Broderick, Kate E., Smith, Trevor R.F.
Publicado 2016

Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics

por Khoshnejad, Makan, Patel, Ami, Wojtak, Krzysztof, Kudchodkar, Sagar B., Humeau, Laurent, Lyssenko, Nicholas N., Rader, Daniel J., Muthumani, Kar, Weiner, David B.
Publicado 2019

Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation

por Schommer, Nina N., Nguyen, Jacklyn, Yung, Bryan S., Schultheis, Katherine, Muthumani, Kar, Weiner, David B., Humeau, Laurent, Broderick, Kate E., Smith, Trevor R.F.
Publicado 2019

Immunogenicity of a protective intradermal DNA vaccine against lassa virus in cynomolgus macaques

por Jiang, Jingjing, Banglore, Preeti, Cashman, Kathleen A., Schmaljohn, Connie S., Schultheis, Katherine, Pugh, Holly, Nguyen, Jacklyn, Humeau, Laurent M., Broderick, Kate E., Ramos, Stephanie J.
Publicado 2019

Immunotherapy of prostate cancer using novel synthetic DNA vaccines targeting multiple tumor antigens

por Bordoloi, Devivasha, Xiao, Peng, Choi, Hyeree, Ho, Michelle, Perales-Puchalt, Alfredo, Khoshnejad, Makan, Kim, J. Joseph, Humeau, Laurent, Srinivasan, Alagarsamy, Weiner, David B., Muthumani, Kar
Publicado 2021

Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo

por Khoshnejad, Makan, Perales-Puchalt, Alfredo, Dia, Yaya, Xiao, Peng, Patel, Ami, Xu, Ziyang, Zhu, Xizhou, Yun, Kun, Baboo, Ishana, Qureshi, Rehman, Humeau, Laurent, Muthumani, Kar, Weiner, David B.
Publicado 2020

Adjuvant Screen Identifies Synthetic DNA-Encoding Flt3L and CD80 Immunotherapeutics as Candidates for Enhancing Anti-tumor T Cell Responses

por Thorne, Amy Haseley, Malo, Kirsten N., Wong, Ashley J., Nguyen, Tricia T., Cooch, Neil, Reed, Charles, Yan, Jian, Broderick, Kate E., Smith, Trevor R. F., Masteller, Emma L., Humeau, Laurent
Publicado 2020

Survival of the Fittest: Positive Selection of CD4+ T Cells Expressing a Membrane-Bound Fusion Inhibitor Following HIV-1 Infection

por Kimpel, Janine, Braun, Stephen E., Qiu, Gang, Wong, Fay Eng, Conolle, Michelle, Schmitz, Jörn E., Brendel, Christian, Humeau, Laurent M., Dropulic, Boro, Rossi, John J., Berger, Annemarie, von Laer, Dorothee, Johnson, R. Paul
Publicado 2010

Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity

por Schultheis, Katherine, Pugh, Holly M, Oh, Janet, Nguyen, Jacklyn, Yung, Bryan, Reed, Charles, Cooch, Neil, Chen, Jing, Yan, Jian, Muthumani, Kar, Humeau, Laurent M., Weiner, David B., Broderick, Kate E., Smith, Trevor R. F.
Publicado 2020

Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model

por Tursi, Nicholas J., Reeder, Sophia M., Flores-Garcia, Yevel, Bah, Mamadou A., Mathis-Torres, Shamika, Salgado-Jimenez, Berenice, Esquivel, Rianne, Xu, Ziyang, Chu, Jacqueline D., Humeau, Laurent, Patel, Ami, Zavala, Fidel, Weiner, David B.
Publicado 2022

DNA vaccine VGX-3100 with electroporation induces regression of cervical intraepithelial neoplasia 2/3 and clears HPV infection with robust T cell responses: results of a randomize...

por Humeau, Laurent, Trimble, Cornelia, Morrow, Matthew, Shen, Xuefei, Dallas, Michael, Weiner, David, Boyer, Jean, Yan, Jian, Kraynyak, Kimberly, Sylvester, Albert, Giffear, Mary, Marcozzi-Pierce, Kathy, Shah, Divya, Broderick, Kate, Khan, Amir, Lee, Jessica, Sardesai, Niranjan, Bargarazzi, Mark
Publicado 2014

Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

por Jiang, Sheng, Wu, Shuting, Zhao, Gan, He, Yue, Bao, Linlin, Liu, Jiangning, Qin, Chuan, Hou, Jiawang, Ding, Yuan, Cheng, Alex, Jiang, Brian, Wu, John, Yan, Jian, Humeau, Laurent, Patella, Ami, Weiner, David B., Broderick, Kate, Wang, Bin
Publicado 2022

Immunotherapy with VGX-3100 (HPV16 and HPV18 plasmids) + INO-9012 (DNA encoding IL-12) in human papillomavirus (HPV) associated head and neck squamous cell carcinoma (HNSCCa): inte...

por Aggarwal, Charu, Cohen, Roger, Morrow, Matthew P, Bauml, Joshua, Weinstein, Gregory, Boyer, Jean, Shen, Xuefei, Yan, Jian, Goldenberg, Jessica, Nashit, Drishty, Oyola, Sandra, Lee, Jessica, Humeau, Laurent M, Weiner, David B, Yang, Zane, Bagarazzi, Mark L, Weiner, David
Publicado 2015

Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model

por Reeder, Sophia M., Reuschel, Emma L., Bah, Mamadou A., Yun, Kun, Tursi, Nicholas J., Kim, Kevin Y., Chu, Jacqueline, Zaidi, Faraz I., Yilmaz, Ilknur, Hart, Robert J., Perrin, Benjamin, Xu, Ziyang, Humeau, Laurent, Weiner, David B., Aly, Ahmed S. I.
Publicado 2020

Protection against Borreliella burgdorferi infection mediated by a synthetically engineered DNA vaccine

por Guibinga, Ghiabe H., Sahay, Bikash, Brown, Heather, Cooch, Neil, Chen, Jing, Yan, Jian, Reed, Charles, Mishra, Meerambika, Yung, Bryan, Pugh, Holly, Schultheis, Katherine, Esquivel, Rianne N., Weiner, David B., Humeau, Laurent H., Broderick, Kate E., Smith, Trevor R.F.
Publicado 2020

Protective immunity by an engineered DNA vaccine for Mayaro virus

por Choi, Hyeree, Kudchodkar, Sagar B., Reuschel, Emma L., Asija, Kanika, Borole, Piyush, Ho, Michelle, Wojtak, Krzysztof, Reed, Charles, Ramos, Stephanie, Bopp, Nathen E., Aguilar, Patricia V., Weaver, Scott C., Kim, J. Joseph, Humeau, Laurent, Tebas, Pablo, Weiner, David B., Muthumani, Kar
Publicado 2019

Multivalent DNA Vaccines as a Strategy to Combat Multiple Concurrent Epidemics: Mosquito-Borne and Hemorrhagic Fever Viruses

por Jiang, Jingjing, Ramos, Stephanie J., Bangalore, Preeti, Elwood, Dustin, Cashman, Kathleen A., Kudchodkar, Sagar B., Schultheis, Katherine, Pugh, Holly, Walters, Jewell, Tur, Jared, Yan, Jian, Patel, Ami, Muthumani, Kar, Schmaljohn, Connie S., Weiner, David B., Humeau, Laurent M., Broderick, Kate E.
Publicado 2021

Mucosal chemokine adjuvant enhances synDNA vaccine-mediated responses to SARS-CoV-2 and provides heterologous protection in vivo

por Gary, Ebony N., Tursi, Nicholas J., Warner, Bryce, Parzych, Elizabeth M., Ali, Ali R., Frase, Drew, Moffat, Estella, Embury-Hyatt, Carissa, Smith, Trevor R.F., Broderick, Kate E., Humeau, Laurent, Kobasa, Darwyn, Patel, Ami, Kulp, Daniel W., Weiner, David B.
Publicado 2022