Development of a Low Bias Method for Characterizing Viral Populations Using Next Generation Sequencing Technology

por Willerth, Stephanie M., Pedro, Hélder A. M., Pachter, Lior, Humeau, Laurent M., Arkin, Adam P., Schaffer, David V.
Publicado 2010

Immunogenicity of a protective intradermal DNA vaccine against lassa virus in cynomolgus macaques

por Jiang, Jingjing, Banglore, Preeti, Cashman, Kathleen A., Schmaljohn, Connie S., Schultheis, Katherine, Pugh, Holly, Nguyen, Jacklyn, Humeau, Laurent M., Broderick, Kate E., Ramos, Stephanie J.
Publicado 2019

Survival of the Fittest: Positive Selection of CD4+ T Cells Expressing a Membrane-Bound Fusion Inhibitor Following HIV-1 Infection

por Kimpel, Janine, Braun, Stephen E., Qiu, Gang, Wong, Fay Eng, Conolle, Michelle, Schmitz, Jörn E., Brendel, Christian, Humeau, Laurent M., Dropulic, Boro, Rossi, John J., Berger, Annemarie, von Laer, Dorothee, Johnson, R. Paul
Publicado 2010

Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity

por Schultheis, Katherine, Pugh, Holly M, Oh, Janet, Nguyen, Jacklyn, Yung, Bryan, Reed, Charles, Cooch, Neil, Chen, Jing, Yan, Jian, Muthumani, Kar, Humeau, Laurent M., Weiner, David B., Broderick, Kate E., Smith, Trevor R. F.
Publicado 2020

Immunotherapy with VGX-3100 (HPV16 and HPV18 plasmids) + INO-9012 (DNA encoding IL-12) in human papillomavirus (HPV) associated head and neck squamous cell carcinoma (HNSCCa): inte...

por Aggarwal, Charu, Cohen, Roger, Morrow, Matthew P, Bauml, Joshua, Weinstein, Gregory, Boyer, Jean, Shen, Xuefei, Yan, Jian, Goldenberg, Jessica, Nashit, Drishty, Oyola, Sandra, Lee, Jessica, Humeau, Laurent M, Weiner, David B, Yang, Zane, Bagarazzi, Mark L, Weiner, David
Publicado 2015

Multivalent DNA Vaccines as a Strategy to Combat Multiple Concurrent Epidemics: Mosquito-Borne and Hemorrhagic Fever Viruses

por Jiang, Jingjing, Ramos, Stephanie J., Bangalore, Preeti, Elwood, Dustin, Cashman, Kathleen A., Kudchodkar, Sagar B., Schultheis, Katherine, Pugh, Holly, Walters, Jewell, Tur, Jared, Yan, Jian, Patel, Ami, Muthumani, Kar, Schmaljohn, Connie S., Weiner, David B., Humeau, Laurent M., Broderick, Kate E.
Publicado 2021

DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections

por Elliott, Sarah T. C., Kallewaard, Nicole L., Benjamin, Ebony, Wachter-Rosati, Leslie, McAuliffe, Josephine M., Patel, Ami, Smith, Trevor R. F., Schultheis, Katherine, Park, Daniel H., Flingai, Seleeke, Wise, Megan C., Mendoza, Janess, Ramos, Stephanie, Broderick, Kate E., Yan, Jian, Humeau, Laurent M., Sardesai, Niranjan Y., Muthumani, Kar, Zhu, Qing, Weiner, David B.
Publicado 2017

Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus

por Patel, Ami, Reuschel, Emma L., Xu, Ziyang, Zaidi, Faraz I., Kim, Kevin Y., Scott, Dana P., Mendoza, Janess, Ramos, Stephanie, Stoltz, Regina, Feldmann, Friederike, Okumura, Atsushi, Meade-White, Kimberly, Haddock, Elaine, Thomas, Tina, Rosenke, Rebecca, Lovaglio, Jamie, Hanley, Patrick W., Saturday, Greg, Muthumani, Kar, Feldmann, Heinz, Humeau, Laurent M., Broderick, Kate E., Weiner, David B.
Publicado 2021

Nanoparticle Vaccines: In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity (Adv...

por Xu, Ziyang, Wise, Megan C., Chokkalingam, Neethu, Walker, Susanne, Tello‐Ruiz, Edgar, Elliott, Sarah T. C., Perales‐Puchalt, Alfredo, Xiao, Peng, Zhu, Xizhou, Pumroy, Ruth A., Fisher, Paul D., Schultheis, Katherine, Schade, Eric, Menis, Sergey, Guzman, Stacy, Andersen, Hanne, Broderick, Kate E., Humeau, Laurent M., Muthumani, Kar, Moiseenkova‐Bell, Vera, Schief, William R., Weiner, David B., Kulp, Daniel W.
Publicado 2020

In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity

por Xu, Ziyang, Wise, Megan C., Chokkalingam, Neethu, Walker, Susanne, Tello‐Ruiz, Edgar, Elliott, Sarah T. C., Perales‐Puchalt, Alfredo, Xiao, Peng, Zhu, Xizhou, Pumroy, Ruth A., Fisher, Paul D., Schultheis, Katherine, Schade, Eric, Menis, Sergey, Guzman, Stacy, Andersen, Hanne, Broderick, Kate E., Humeau, Laurent M., Muthumani, Kar, Moiseenkova‐Bell, Vera, Schief, William R., Weiner, David B., Kulp, Daniel W.
Publicado 2020

INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants

por Andrade, Viviane M., Christensen-Quick, Aaron, Agnes, Joseph, Tur, Jared, Reed, Charles, Kalia, Richa, Marrero, Idania, Elwood, Dustin, Schultheis, Katherine, Purwar, Mansi, Reuschel, Emma, McMullan, Trevor, Pezzoli, Patrick, Kraynyak, Kim, Sylvester, Albert, Mammen, Mammen P., Tebas, Pablo, Joseph Kim, J., Weiner, David B., Smith, Trevor R. F., Ramos, Stephanie J., Humeau, Laurent M., Boyer, Jean D., Broderick, Kate E.
Publicado 2021

Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates

por Walters, Jewell N., Schouest, Blake, Patel, Ami, Reuschel, Emma L., Schultheis, Katherine, Parzych, Elizabeth, Maricic, Igor, Gary, Ebony N., Purwar, Mansi, Andrade, Viviane M., Doan, Arthur, Elwood, Dustin, Eblimit, Zeena, Nguyen, Brian, Frase, Drew, Zaidi, Faraz I., Kulkarni, Abhijeet, Generotti, Alison, Joseph Kim, J, Humeau, Laurent M., Ramos, Stephanie J., Smith, Trevor R.F., Weiner, David B., Broderick, Kate E.
Publicado 2022

One or two dose regimen of the SARS-CoV-2 synthetic DNA vaccine INO-4800 protects against respiratory tract disease burden in nonhuman primate challenge model

por Gooch, Karen E., Smith, Trevor R.F., Salguero, Francisco J., Fotheringham, Susan A., Watson, Robert J., Dennis, Mike J., Handley, Alastair, Humphries, Holly E., Longet, Stephanie, Tipton, Tom, Sarfas, Charlotte, Sibley, Laura, Slack, Gillian S., Rayner, Emma, Ryan, Kathryn A., Schultheis, Katherine, Ramos, Stephanie J., White, Andrew, Charlton, Sue, Sharpe, Sally A., Gleeson, Fergus, Humeau, Laurent M., Hall, Yper, Broderick, Kate E., Carroll, Miles W.
Publicado 2021

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection

por Konrath, Kylie M., Liaw, Kevin, Wu, Yuanhan, Zhu, Xizhou, Walker, Susanne N., Xu, Ziyang, Schultheis, Katherine, Chokkalingam, Neethu, Chawla, Himanshi, Du, Jianqiu, Tursi, Nicholas J., Moore, Alan, Adolf-Bryfogle, Jared, Purwar, Mansi, Reuschel, Emma L., Frase, Drew, Sullivan, Matthew, Fry, Benjamin, Maricic, Igor, Andrade, Viviane M., Iffland, Christel, Crispin, Max, Broderick, Kate E., Humeau, Laurent M.P.F., Patel, Ami, Smith, Trevor R.F., Pallesen, Jesper, Weiner, David B., Kulp, Daniel W.
Publicado 2022

Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial

por Tebas, Pablo, Yang, ShuPing, Boyer, Jean D., Reuschel, Emma L., Patel, Ami, Christensen-Quick, Aaron, Andrade, Viviane M., Morrow, Matthew P., Kraynyak, Kimberly, Agnes, Joseph, Purwar, Mansi, Sylvester, Albert, Pawlicki, Jan, Gillespie, Elisabeth, Maricic, Igor, Zaidi, Faraz I., Kim, Kevin Y., Dia, Yaya, Frase, Drew, Pezzoli, Patrick, Schultheis, Katherine, Smith, Trevor R.F., Ramos, Stephanie J., McMullan, Trevor, Buttigieg, Karen, Carroll, Miles W., Ervin, John, Diehl, Malissa C., Blackwood, Elliott, Mammen, Mammen P., Lee, Jessica, Dallas, Michael J., Brown, Ami Shah, Shea, Jacqueline E., Kim, J.Joseph, Weiner, David B., Broderick, Kate E., Humeau, Laurent M.
Publicado 2020

Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model

por Patel, Ami, Walters, Jewell N., Reuschel, Emma L., Schultheis, Katherine, Parzych, Elizabeth, Gary, Ebony N., Maricic, Igor, Purwar, Mansi, Eblimit, Zeena, Walker, Susanne N., Guimet, Diana, Bhojnagarwala, Pratik, Adeniji, Opeyemi S., Doan, Arthur, Xu, Ziyang, Elwood, Dustin, Reeder, Sophia M., Pessaint, Laurent, Kim, Kevin Y., Cook, Anthony, Chokkalingam, Neethu, Finneyfrock, Brad, Tello-Ruiz, Edgar, Dodson, Alan, Choi, Jihae, Generotti, Alison, Harrison, John, Tursi, Nicholas J., Andrade, Viviane M., Dia, Yaya, Zaidi, Faraz I., Andersen, Hanne, Abdel-Mohsen, Mohamed, Lewis, Mark G., Muthumani, Kar, Kim, J. Joseph, Kulp, Daniel W., Humeau, Laurent M., Ramos, Stephanie J., Smith, Trevor R.F., Weiner, David B., Broderick, Kate E.
Publicado 2021

Immunogenicity of a DNA vaccine candidate for COVID-19

por Smith, Trevor R. F., Patel, Ami, Ramos, Stephanie, Elwood, Dustin, Zhu, Xizhou, Yan, Jian, Gary, Ebony N., Walker, Susanne N., Schultheis, Katherine, Purwar, Mansi, Xu, Ziyang, Walters, Jewell, Bhojnagarwala, Pratik, Yang, Maria, Chokkalingam, Neethu, Pezzoli, Patrick, Parzych, Elizabeth, Reuschel, Emma L., Doan, Arthur, Tursi, Nicholas, Vasquez, Miguel, Choi, Jihae, Tello-Ruiz, Edgar, Maricic, Igor, Bah, Mamadou A., Wu, Yuanhan, Amante, Dinah, Park, Daniel H., Dia, Yaya, Ali, Ali Raza, Zaidi, Faraz I., Generotti, Alison, Kim, Kevin Y., Herring, Timothy A., Reeder, Sophia, Andrade, Viviane M., Buttigieg, Karen, Zhao, Gan, Wu, Jiun-Ming, Li, Dan, Bao, Linlin, Liu, Jiangning, Deng, Wei, Qin, Chuan, Brown, Ami Shah, Khoshnejad, Makan, Wang, Nianshuang, Chu, Jacqueline, Wrapp, Daniel, McLellan, Jason S., Muthumani, Kar, Wang, Bin, Carroll, Miles W., Kim, J. Joseph, Boyer, Jean, Kulp, Daniel W., Humeau, Laurent M. P. F., Weiner, David B., Broderick, Kate E.
Publicado 2020