Relative Contribution of Framework and CDR Regions in Antibody Variable Domains to Multimerisation of Fv- and scFv-Containing Bispecific Antibodies

por Bhatta, Pallavi, Humphreys, David P.
Publicado 2018

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design

por Stoyle, Chloe L., Stephens, Paul E., Humphreys, David P., Heywood, Sam, Cain, Katharine, Bulleid, Neil J.
Publicado 2017

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection again...

por Monaghan, Tanya M, Negm, Ola H, MacKenzie, Brendon, Hamed, Mohamed R, Shone, Clifford C, Humphreys, David P, Acharya, K Ravi, Wilcox, Mark H
Publicado 2017

Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum hal...

por Adams, Ralph, Griffin, Laura, Compson, Joanne E., Jairaj, Mark, Baker, Terry, Ceska, Tom, West, Shauna, Zaccheo, Oliver, Davé, Emma, Lawson, Alastair DG., Humphreys, David P., Heywood, Sam
Publicado 2016

On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation

por Sopp, Joshua M., Peters, Shirley J., Rowley, Tania F., Oldham, Robert J., James, Sonya, Mockridge, Ian, French, Ruth R., Turner, Alison, Beers, Stephen A., Humphreys, David P., Cragg, Mark S.
Publicado 2021

Escherichia coli “TatExpress” strains export several g/L human growth hormone to the periplasm by the Tat pathway

por Guerrero Montero, Isabel, Richards, Kirsty L., Jawara, Chillel, Browning, Douglas F., Peswani, Amber R., Labrit, Mickael, Allen, Matthew, Aubry, Cedric, Davé, Emma, Humphreys, David P., Busby, Stephen J. W., Robinson, Colin
Publicado 2019

Impact of Human FcγR Gene Polymorphisms on IgG-Triggered Cytokine Release: Critical Importance of Cell Assay Format

por Hussain, Khiyam, Hargreaves, Chantal E., Rowley, Tania F., Sopp, Joshua M., Latham, Kate V., Bhatta, Pallavi, Sherington, John, Cutler, Rona M., Humphreys, David P., Glennie, Martin J., Strefford, Jonathan C., Cragg, Mark S.
Publicado 2019

TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life

por Davé, Emma, Durrant, Oliver, Dhami, Neha, Compson, Joanne, Broadbridge, Janice, Archer, Sophie, Maroof, Asher, Whale, Kevin, Menochet, Karelle, Bonnaillie, Pierre, Barry, Emily, Wild, Gavin, Peerboom, Claude, Bhatta, Pallavi, Ellis, Mark, Hinchliffe, Matthew, Humphreys, David P., Heywood, Sam P.
Publicado 2023

Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding

por Davé, Emma, Adams, Ralph, Zaccheo, Oliver, Carrington, Bruce, Compson, Joanne E., Dugdale, Sarah, Airey, Michael, Malcolm, Sarah, Hailu, Hanna, Wild, Gavin, Turner, Alison, Heads, James, Sarkar, Kaushik, Ventom, Andrew, Marshall, Diane, Jairaj, Mark, Kopotsha, Tim, Christodoulou, Louis, Zamacona, Miren, Lawson, Alastair D., Heywood, Sam, Humphreys, David P.
Publicado 2016

Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions

por Rowley, Tania F., Peters, Shirley J., Aylott, Mike, Griffin, Robert, Davies, Nicola L., Healy, Louise J., Cutler, Rona M., Eddleston, Alison, Pither, Thomas L., Sopp, Joshua M., Zaccheo, Oliver, Fossati, Gianluca, Cain, Katharine, Ventom, Andrew M., Hailu, Hanna, Ward, Eleanor J., Sherington, John, Brennan, Frank R., Fallah-Arani, Farnaz, Humphreys, David P.
Publicado 2018