Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis

por Hu, Xiaohu, Wang, Yibo, Hunkele, Amanda, Provasi, Davide, Pasternak, Gavril W., Filizola, Marta
Publicado 2019

Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception

por Urai, Ákos, Váradi, András, Szőcs, Levente, Komjáti, Balázs, Le Rouzic, Valerie, Hunkele, Amanda, Pasternak, Gavril W., Majumdar, Susruta, Hosztafi, Sándor
Publicado 2016

Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy

por Bhowmik, Srijita, Galeta, Juraj, Havel, Václav, Nelson, Melissa, Faouzi, Abdelfattah, Bechand, Benjamin, Ansonoff, Mike, Fiala, Tomas, Hunkele, Amanda, Kruegel, Andrew C., Pintar, John. E., Majumdar, Susruta, Javitch, Jonathan A., Sames, Dalibor
Publicado 2021

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

por Uprety, Rajendra, Che, Tao, Zaidi, Saheem A, Grinnell, Steven G, Varga, Balázs R, Faouzi, Abdelfattah, Slocum, Samuel T, Allaoa, Abdullah, Varadi, András, Nelson, Melissa, Bernhard, Sarah M, Kulko, Elizaveta, Le Rouzic, Valerie, Eans, Shainnel O, Simons, Chloe A, Hunkele, Amanda, Subrath, Joan, Pan, Ying Xian, Javitch, Jonathan A, McLaughlin, Jay P, Roth, Bryan L, Pasternak, Gavril W, Katritch, Vsevolod, Majumdar, Susruta
Publicado 2021