c-Rel and its many roles in cancer: an old story with new twists

por Hunter, Jill E, Leslie, Jack, Perkins, Neil D
Publicado 2016

Ionizing radiation-induced NF-κB activation requires PARP-1 function to confer radio-resistance

por Veuger, Stephany J., Hunter, Jill E., Durkacz, Barbara W.
Publicado 2008

Increased migration and motility in XIAP-null cells mediated by the C-RAF protein kinase

por Russell, Lauren G., Davis, Lydia A. K., Hunter, Jill E., Perkins, Neil D., Kenneth, Niall S.
Publicado 2022

NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699

por Hunter, Jill E., Willmore, Elaine, Irving, Julie A. E., Hostomsky, Zdenek, Veuger, Stephany J., Durkacz, Barbara W.
Publicado 2011

Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12

por Sandhu, Sumit, Sou, Ieng F., Hunter, Jill E., Salmon, Lucy, Wilson, Caroline L., Perkins, Neil D., Hunter, Neil, Davies, Owen R., McClurg, Urszula L.
Publicado 2021

Expression and Activity of the NF-κB Subunits in Chronic Lymphocytic Leukaemia: A Role for RelB and Non-Canonical Signalling

por Mulligan, Evan A., Tudhope, Susan J., Hunter, Jill E., Clift, Arabella E. G., Elliott, Sarah L., Summerfield, Geoffrey P., Wallis, Jonathan, Pepper, Chris J., Durkacz, Barabara, Veuger, Stephany, Willmore, Elaine
Publicado 2023

Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential

por Madgwick, Suzanne, Luli, Saimir, Sellier, Helene, Butterworth, Jacqueline A., Leslie, Jack, Moore, Adam J., Corbin, Emma K., Yemm, Adrian I., Chiremba, Robson T., Tiniakos, Dina, Oakley, Fiona, Perkins, Neil D., Hunter, Jill E.
Publicado 2022

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

por Hunter, Jill E., Campbell, Amy E., Kerridge, Scott, Fraser, Callum, Hannaway, Nicola L., Luli, Saimir, Ivanova, Iglika, Brownridge, Philip J., Coxhead, Jonathan, Taylor, Leigh, Leary, Peter, Hasoon, Megan S. R., Eyers, Claire E., Perkins, Neil D.
Publicado 2022

PARP1 expression, activity and ex vivo sensitivity to the PARP inhibitor, talazoparib (BMN 673), in chronic lymphocytic leukaemia

por Herriott, Ashleigh, Tudhope, Susan J., Junge, Gesa, Rodrigues, Natalie, Patterson, Miranda J., Woodhouse, Laura, Lunec, John, Hunter, Jill E., Mulligan, Evan A., Cole, Michael, Allinson, Lisa M., Wallis, Jonathan P., Marshall, Scott, Wang, Evelyn, Curtin, Nicola J., Willmore, Elaine
Publicado 2015

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

por Leslie, Jack, Hunter, Jill E., Collins, Amy, Rushton, Amelia, Russell, Lauren G., Ramon‐Gil, Erik, Laszczewska, Maja, McCain, Misti, Zaki, Marco Y. W., Knox, Amber, Seow, Yixin, Sabater, Laura, Geh, Daniel, Perkins, Neil D., Reeves, Helen L., Tiniakos, Dina, Mann, Derek A., Oakley, Fiona
Publicado 2023

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

por Hunter, Jill E., Campbell, Amy E., Butterworth, Jacqueline A., Sellier, Helene, Hannaway, Nicola L., Luli, Saimir, Floudas, Achilleas, Kenneth, Niall S., Moore, Adam J., Brownridge, Philip J., Thomas, Huw D., Coxhead, Jonathan, Taylor, Leigh, Leary, Peter, Hasoon, Megan S.R., Knight, Andrew M., Garrett, Michelle D., Collins, Ian, Eyers, Claire E., Perkins, Neil D.
Publicado 2022

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

por Hunter, Jill E., Campbell, Amy E., Hannaway, Nicola L., Kerridge, Scott, Luli, Saimir, Butterworth, Jacqueline A., Sellier, Helene, Mukherjee, Reshmi, Dhillon, Nikita, Sudhindar, Praveen D., Shukla, Ruchi, Brownridge, Philip J., Bell, Hayden L., Coxhead, Jonathan, Taylor, Leigh, Leary, Peter, Hasoon, Megan S.R., Collins, Ian, Garrett, Michelle D., Eyers, Claire E., Perkins, Neil D.
Publicado 2022

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma

por Walton, Mike I., Eve, Paul D., Hayes, Angela, Henley, Alan T., Valenti, Melanie R., De Haven Brandon, Alexis K., Box, Gary, Boxall, Kathy J., Tall, Matthew, Swales, Karen, Matthews, Thomas P., McHardy, Tatiana, Lainchbury, Michael, Osborne, James, Hunter, Jill E., Perkins, Neil D., Aherne, G. Wynne, Reader, John C., Raynaud, Florence I., Eccles, Suzanne A., Collins, Ian, Garrett, Michelle D.
Publicado 2015