The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis

por Stephenson, Katherine E., Porte, Joanne, Kelly, Aoife, Wallace, William A., Huntington, Catherine E., Overed-Sayer, Catherine L., Cohen, E. Suzanne, Jenkins, R. Gisli, John, Alison E.
Publicado 2023

Haplosaurus computes protein haplotypes for use in precision drug design

por Spooner, William, McLaren, William, Slidel, Timothy, Finch, Donna K., Butler, Robin, Campbell, Jamie, Eghobamien, Laura, Rider, David, Kiefer, Christine Mione, Robinson, Matthew J., Hardman, Colin, Cunningham, Fiona, Vaughan, Tristan, Flicek, Paul, Huntington, Catherine Chaillan
Publicado 2018

Affinity maturation of a novel antagonistic human monoclonal antibody with a long V(H) CDR3 targeting the Class A GPCR formyl-peptide receptor 1

por Douthwaite, Julie A, Sridharan, Sudharsan, Huntington, Catherine, Hammersley, Jayne, Marwood, Rose, Hakulinen, Jonna K, Ek, Margareta, Sjögren, Tove, Rider, David, Privezentzev, Cyril, Seaman, Jonathan C, Cariuk, Peter, Knights, Vikki, Young, Joyce, Wilkinson, Trevor, Sleeman, Matthew, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Publicado 2014

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction

por England, Elizabeth, Rees, D. Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T. Y., Chaillan Huntington, Catherine E., Houslay, Kirsty F., Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B., Rapley, Laura, Sims, Dorothy A., Hollins, Claire, Hinchy, Elizabeth C., Strain, Martin D., Kemp, Benjamin P., Corkill, Dominic J., May, Richard D., Vousden, Katherine A., Butler, Robin J., Mustelin, Tomas, Vaughan, Tristan J., Lowe, David C., Colley, Caroline, Cohen, E. Suzanne
Publicado 2023

Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex

por Strickson, Sam, Houslay, Kirsty F., Negri, Victor A., Ohne, Yoichiro, Ottosson, Tomas, Dodd, Roger B., Huntington, Catherine Chaillan, Baker, Tina, Li, Jingjing, Stephenson, Katherine E., O'Connor, Andy J., Sagawe, J. Sophie, Killick, Helen, Moore, Tom, Rees, D. Gareth, Koch, Sofia, Sanden, Caroline, Wang, Yixin, Gubbins, Elise, Ghaedi, Mahboobe, Kolbeck, Roland, Saumyaa, Saumyaa, Erjefält, Jonas S., Sims, Gary P., Humbles, Alison A., Scott, Ian C., Romero Ros, Xavier, Cohen, E. Suzanne
Publicado 2023

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

por Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas
Publicado 2015