Systematic interrogation of diverse Omic data reveals interpretable, robust, and generalizable transcriptomic features of clinically successful therapeutic targets

por Rouillard, Andrew D., Hurle, Mark R., Agarwal, Pankaj
Publicado 2018

Predicting clinically promising therapeutic hypotheses using tensor factorization

por Yao, Jin, Hurle, Mark R., Nelson, Matthew R., Agarwal, Pankaj
Publicado 2019

Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues

por Kumar, Vinod, Sanseau, Philippe, Simola, Daniel F., Hurle, Mark R., Agarwal, Pankaj
Publicado 2016

Network and pathway expansion of genetic disease associations identifies successful drug targets

por MacNamara, Aidan, Nakic, Nikolina, Amin Al Olama, Ali, Guo, Cong, Sieber, Karsten B., Hurle, Mark R., Gutteridge, Alex
Publicado 2020

Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease

por Reisdorf, William C., Xie, Qing, Zeng, Xin, Xie, Wensheng, Rajpal, Neetu, Hoang, Bao, Burgert, Mark E., Kumar, Vinod, Hurle, Mark R., Rajpal, Deepak K., O’Donnell, Sarah, MacDonald, Thomas T., Vossenkämper, Anna, Wang, Lin, Reilly, Mike, Votta, Bart J., Sanchez, Yolanda, Agarwal, Pankaj
Publicado 2019

Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery

por Rebollo-Lopez, María Jose, Lelièvre, Joël, Alvarez-Gomez, Daniel, Castro-Pichel, Julia, Martínez-Jiménez, Francisco, Papadatos, George, Kumar, Vinod, Colmenarejo, Gonzalo, Mugumbate, Grace, Hurle, Mark, Barroso, Vanessa, Young, Rob J., Martinez-Hoyos, María, González del Río, Rubén, Bates, Robert H., Lopez-Roman, Eva Maria, Mendoza-Losana, Alfonso, Brown, James R., Alvarez-Ruiz, Emilio, Marti-Renom, Marc A., Overington, John P., Cammack, Nicholas, Ballell, Lluís, Barros-Aguire, David
Publicado 2015

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

por Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip C., Hurle, Mark R., Gutteridge, Alex, Erola, Pau, Liu, Yi, Luo, Shan, Robinson, Jamie, Richardson, Tom G., Staley, James R., Elsworth, Benjamin, Burgess, Stephen, Sun, Benjamin B., Danesh, John, Runz, Heiko, Maranville, Joseph C., Martin, Hannah M., Yarmolinsky, James, Laurin, Charles, Holmes, Michael V., Liu, Jimmy Z., Estrada, Karol, Santos, Rita, McCarthy, Linda, Waterworth, Dawn, Nelson, Matthew R., Smith, George Davey, Butterworth, Adam S., Hemani, Gibran, Scott, Robert A., Gaunt, Tom R.
Publicado 2020