Targeting opioid receptor signaling in depression: do we need selective κ opioid receptor antagonists?

por Bailey, Sarah J., Husbands, Stephen M.
Publicado 2018

Synthetic Cannabinoid Receptor Agonists Detection Using Fluorescence Spectral Fingerprinting

por May, Benedict, Naqi, Husain A., Tipping, Michael, Scott, Jenny, Husbands, Stephen M., Blagbrough, Ian S., Pudney, Christopher R.
Publicado 2019

The novel μ‐opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

por Hill, Rob, Disney, Alex, Conibear, Alex, Sutcliffe, Katy, Dewey, William, Husbands, Stephen, Bailey, Chris, Kelly, Eamonn, Henderson, Graeme
Publicado 2018

Behavioural tasks sensitive to acute abstinence and predictive of smoking cessation success: a systematic review and meta‐analysis

por Grabski, Meryem, Curran, H. Valerie, Nutt, David J., Husbands, Stephen M., Freeman, Tom P., Fluharty, Meg, Munafò, Marcus R.
Publicado 2016

Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid...

por Kumar, Vinod, Polgar, Willma E., Cami-Kobeci, Gerta, Thomas, Mark P., Khroyan, Taline V., Toll, Lawrence, Husbands, Stephen M.
Publicado 2018

Additive Effects of 3,4-Methylenedioxymethamphetamine (MDMA) and Compassionate Imagery on Self-Compassion in Recreational Users of Ecstasy

por Kamboj, Sunjeev K., Walldén, Ylva S. E., Falconer, Caroline J., Alotaibi, Majdah Raji, Blagbrough, Ian S., Husbands, Stephen M., Freeman, Tom P.
Publicado 2017

Opioid Antagonists from the Orvinol Series as Potential Reversal Agents for Opioid Overdose

por Disney, Alex, Olson, Keith M., Shafer, Amanda M., Moore, Sierra C., Anand, Jessica P., Traynor, John R., Husbands, Stephen M.
Publicado 2022

Identification of an imidazoline binding protein: Creatine kinase and an imidazoline-2 binding site

por Kimura, Atsuko, Tyacke, Robin J., Robinson, James J., Husbands, Stephen M., Minchin, Michael C.W., Nutt, David J., Hudson, Alan L.
Publicado 2009

C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu...

por Cueva, Juan Pablo, Roche, Christopher, Ostovar, Mehrnoosh, Kumar, Vinod, Clark, Mary J., Hillhouse, Todd M., Lewis, John W., Traynor, John R., Husbands, Stephen M.
Publicado 2015

Long‐term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox

por Zamora, Joshua C., Smith, Hudson R., Jennings, Elaine M., Chavera, Teresa S., Kotipalli, Varun, Jay, Aleasha, Husbands, Stephen M., Disney, Alex, Berg, Kelly A., Clarke, William P.
Publicado 2021

Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity

por Kumar, Vinod, Ridzwan, Irna E., Grivas, Konstantinos, Lewis, John W., Clark, Mary J., Meurice, Claire, Jimenez-Gomez, Corina, Pogozheva, Irina, Mosberg, Henry, Traynor, John R., Husbands, Stephen M.
Publicado 2014

Orvinols with Mixed Kappa/Mu Opioid Receptor Agonist Activity

por Greedy, Benjamin M., Bradbury, Faye, Thomas, Mark P., Grivas, Konstantinos, Cami-Kobeci, Gerta, Archambeau, Ashley, Bosse, Kelly, Clark, Mary J., Aceto, Mario, Lewis, John W., Traynor, John R., Husbands, Stephen M.
Publicado 2013

Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible μ Opioid Receptor Antagonist Effects

por Moynihan, Humphrey A., Derrick, Ian., Broadbear, Jillian H., Greedy, Benjamin M., Aceto, Mario D., Harris, Louis S., Purington, Lauren C. S., Thomas, Mark P., Woods, James H., Traynor, John R., Husbands, Stephen M., Lewis, John W.
Publicado 2012

Instant Detection of Synthetic Cannabinoids on Physical Matrices, Implemented on a Low-Cost, Ultraportable Device

por Cozier, Gyles E., Andrews, Rachael C., Frinculescu, Anca, Kumar, Ranjeet, May, Benedict, Tooth, Tom, Collins, Peter, Costello, Andrew, Haines, Tom S. F., Freeman, Tom P., Blagbrough, Ian S., Scott, Jennifer, Shine, Trevor, Sutcliffe, Oliver B., Husbands, Stephen M., Leach, Jonathan, Bowman, Richard W., Pudney, Christopher R.
Publicado 2023

Structural insights into μ-opioid receptor activation

por Huang, Weijiao, Manglik, Aashish, Venkatakrishnan, A. J., Laeremans, Toon, Feinberg, Evan N., Sanborn, Adrian L., Kato, Hideaki E., Livingston, Kathryn E., Thorsen, Thor S., Kling, Ralf, Granier, Sébastien, Gmeiner, Peter, Husbands, Stephen M., Traynor, John R., Weis, William I., Steyaert, Jan, Dror, Ron O., Kobilka, Brian K.
Publicado 2015

Photochemical Fingerprinting Is a Sensitive Probe for the Detection of Synthetic Cannabinoid Receptor Agonists; toward Robust Point-of-Care Detection

por Andrews, Rachael C., May, Benedict, Hernández, Federico J., Cozier, Gyles E., Townsend, Piers A., Sutcliffe, Oliver B., Haines, Tom S. F., Freeman, Tom P., Scott, Jennifer, Husbands, Stephen M., Blagbrough, Ian S., Bowman, Richard W., Lewis, Simon E., Grayson, Matthew N., Crespo-Otero, Rachel, Carbery, David R., Pudney, Christopher R.
Publicado 2023