The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN...

por Mazzacurati, Lucia, Lambert, Que T., Pradhan, Anuradha, Griner, Lori N., Huszar, Dennis, Reuther, Gary W.
Publicado 2015

Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress

por Doshi, Kshama A., Trotta, Rossana, Natarajan, Karthika, Rassool, Feyruz V., Tron, Adriana E., Huszar, Dennis, Perrotti, Danilo, Baer, Maria R.
Publicado 2016

Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse large B cell lymphoma

por Ezell, Scott A., Wang, Suping, Bihani, Teeru, Lai, Zhongwu, Grosskurth, Shaun E., Tepsuporn, Suprawee, Davies, Barry R., Huszar, Dennis, Byth, Kate F.
Publicado 2016

Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment

por Derry, Jonathan M.J., Burns, Connor, Frazier, Jason P., Beirne, Emily, Grenley, Marc, DuFort, Christopher C., Killingbeck, Emily, Leon, Michael, Williams, Claire, Gregory, Mark, Houlton, Jeffrey, Clayburgh, Daniel, Swiecicki, Paul, Huszar, Dennis, Berger, Allison, Klinghoffer, Richard A.
Publicado 2023

A sumoylation program is essential for maintaining the mitotic fidelity in proliferating mantle cell lymphoma cells

por Hanel, Walter, Lata, Pushpa, Youssef, Youssef, Tran, Ha, Tsyba, Liudmyla, Sehgal, Lalit, Blaser, Bradley W., Huszar, Dennis, Helmig-Mason, JoBeth, Zhang, Liwen, Schrock, Morgan S., Summers, Matthew K., Chan, Wing Keung, Prouty, Alexander, Mundy-Bosse, Bethany L., Chen-Kiang, Selina, Danilov, Alexey V., Maddocks, Kami, Baiocchi, Robert A., Alinari, Lapo
Publicado 2022