Evaluating the Use of Linear Mixed-Effect Models for Inference of the Concentration-QTc Slope Estimate as a Surrogate for a Biological QTc Model

por Huh, Y, Hutmacher, MM
Publicado 2015

Population Exposure‐Response Modeling of Naloxegol in Patients With Noncancer‐Related Pain and Opioid‐Induced Constipation

por Al‐Huniti, N, Nielsen, JC, Hutmacher, MM, Lappalainen, J, Cantagallo, K, Sostek, M
Publicado 2016

Model‐Informed Development and Registration of a Once‐Daily Regimen of Extended‐Release Tofacitinib

por Lamba, M, Hutmacher, MM, Furst, DE, Dikranian, A, Dowty, ME, Conrado, D, Stock, T, Nduaka, C, Cook, J, Krishnaswami, S
Publicado 2017

Evaluating Dosage Optimality for Tofacitinib, an Oral Janus Kinase Inhibitor, in Plaque Psoriasis, and the Influence of Body Weight

por Hutmacher, MM, Papp, K, Krishnaswami, S, Ito, K, Tan, H, Wolk, R, Valdez, H, Mebus, C, Rottinghaus, ST, Gupta, P
Publicado 2017