Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation

por Markowicz-Piasecka, Magdalena, Huttunen, Kristiina M., Sikora, Joanna
Publicado 2018

L-Type amino acid transporter 1 as a target for drug delivery

por Puris, Elena, Gynther, Mikko, Auriola, Seppo, Huttunen, Kristiina M.
Publicado 2020

L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels

por Montaser, Ahmed, Lehtonen, Marko, Gynther, Mikko, Huttunen, Kristiina M.
Publicado 2020

Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival

por Tampio, Janne, Huttunen, Johanna, Montaser, Ahmed, Huttunen, Kristiina M.
Publicado 2020

Sulfenamide and Sulfonamide Derivatives of Metformin – A New Option to Improve Endothelial Function and Plasma Haemostasis

por Markowicz-Piasecka, Magdalena, Huttunen, Kristiina M., Broncel, Marlena, Sikora, Joanna
Publicado 2019

Astrocyte-Targeted Transporter-Utilizing Derivatives of Ferulic Acid Can Have Multifunctional Effects Ameliorating Inflammation and Oxidative Stress in the Brain

por Montaser, Ahmed, Huttunen, Johanna, Ibrahim, Sherihan Abdelhamid, Huttunen, Kristiina M.
Publicado 2019

Pleiotropic Activity of Metformin and Its Sulfonamide Derivatives on Vascular and Platelet Haemostasis

por Markowicz-Piasecka, Magdalena, Huttunen, Kristiina M., Sadkowska, Adrianna, Sikora, Joanna
Publicado 2019

Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

por Markowicz-Piasecka, Magdalena, Huttunen, Johanna, Montaser, Ahmed, Huttunen, Kristiina M.
Publicado 2020

Structural Comparison of Sulfonamide-Based Derivatives That Can Improve Anti-Coagulation Properties of Metformin

por Zajda, Agnieszka, Sikora, Joanna, Huttunen, Kristiina M., Markowicz-Piasecka, Magdalena
Publicado 2022

Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs)

por Huttunen, Johanna, Adla, Santosh Kumar, Markowicz-Piasecka, Magdalena, Huttunen, Kristiina M.
Publicado 2022

Effective Cellular Transport of Ortho-Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells

por Markowicz-Piasecka, Magdalena, Komeil, Ibrahim, Huttunen, Johanna, Sikora, Joanna, Huttunen, Kristiina M.
Publicado 2020

Novel Sulfonamide-Based Analogs of Metformin Exert Promising Anti-Coagulant Effects without Compromising Glucose-Lowering Activity

por Markowicz-Piasecka, Magdalena, Sadkowska, Adrianna, Sikora, Joanna, Broncel, Marlena, Huttunen, Kristiina M.
Publicado 2020

Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells

por Markowicz-Piasecka, Magdalena, Sadowski, Karol, Huttunen, Johanna, Sikora, Joanna, Huttunen, Kristiina M.
Publicado 2021

Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

por Huttunen, Johanna, Agami, Mahmoud, Tampio, Janne, Montaser, Ahmed B., Huttunen, Kristiina M.
Publicado 2021

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

por Huttunen, Kristiina M., Terasaki, Tetsuya, Urtti, Arto, Montaser, Ahmed B., Uchida, Yasuo
Publicado 2022

Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity

por Markowicz-Piasecka, Magdalena, Sikora, Joanna, Mateusiak, Łukasz, Mikiciuk-Olasik, Elżbieta, Huttunen, Kristiina M.
Publicado 2017

Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes

por Tonduru, Arun Kumar, Adla, Santosh Kumar, Huttunen, Kristiina M., Kronenberger, Thales, Poso, Antti
Publicado 2022

L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Prod...

por Tampio, Janne, Markowicz-Piasecka, Magdalena, Montaser, Ahmed, Rysä, Jaana, Kauppinen, Anu, Huttunen, Kristiina M.
Publicado 2022

Metformin – a Future Therapy for Neurodegenerative Diseases: Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla

por Markowicz-Piasecka, Magdalena, Sikora, Joanna, Szydłowska, Aleksandra, Skupień, Agata, Mikiciuk-Olasik, Elżbieta, Huttunen, Kristiina M.
Publicado 2017

Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2

por Adla, Santosh Kumar, Tonduru, Arun Kumar, Kronenberger, Thales, Kudova, Eva, Poso, Antti, Huttunen, Kristiina M.
Publicado 2021