Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPP(swe) Mice Without Inducing Microhemorrhage

por Villarreal, Stephanie, Zhao, Fuqiang, Hyde, Lynn A., Holder, Daniel, Forest, Thomas, Sondey, Marie, Chen, Xia, Sur, Cyrille, Parker, Eric M., Kennedy, Matthew E.
Publicado 2017

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

por Song, Lixin, Lu, Sherry X, Ouyang, Xuesong, Melchor, Jerry, Lee, Julie, Terracina, Giuseppe, Wang, Xiaohai, Hyde, Lynn, Hess, J Fred, Parker, Eric M, Zhang, Lili
Publicado 2015

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

por Hyde, Lynn A., Zhang, Qi, Del Vecchio, Robert A., Leach, Prescott T., Cohen-Williams, Mary E., Chen, Lei, Wong, Gwendolyn T., McHugh, Nansie A., Chen, Joseph, Higgins, Guy A., Asberom, Theodros, Li, Wei, Pissarnitski, Dmitri, Levitan, Diane, Nomeir, Amin A., Clader, John W., Zhang, Lili, Parker, Eric M.
Publicado 2013

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

por Hastings, Nicholas B., Wang, Xiaohai, Song, Lixin, Butts, Brent D., Grotz, Diane, Hargreaves, Richard, Fred Hess, J., Hong, Kwok-Lam Karen, Huang, Cathy Ruey-Ruey, Hyde, Lynn, Laverty, Maureen, Lee, Julie, Levitan, Diane, Lu, Sherry X., Maguire, Maureen, Mahadomrongkul, Veeravan, McEachern, Ernest J., Ouyang, Xuesong, Rosahl, Thomas W., Selnick, Harold, Stanton, Michaela, Terracina, Giuseppe, Vocadlo, David J., Wang, Ganfeng, Duffy, Joseph L., Parker, Eric M., Zhang, Lili
Publicado 2017