Picking the Right Patient for Human Epidermal Growth Factor Receptor 3–Targeted Therapy in Platinum-Resistant Ovarian Cancer

por Schram, Alison M., Iasonos, Alexia, Hyman, David M.
Publicado 2016

Precision oncology: Charting a path forward to broader deployment of genomic profiling

por Schram, Alison M., Berger, Michael F., Hyman, David M.
Publicado 2017

Primary debulking surgery for metastatic cervical adenocarcinoma: A case report

por Davenport, Sara M., Suidan, Rudy S., Huang, James, Hyman, David M., Chi, Dennis S.
Publicado 2015

Challenges and Opportunities in Dose Finding in Oncology and Immuno‐oncology

por Ji, Yan, Jin, Jin Y., Hyman, David M., Kim, Geoffrey, Suri, Ajit
Publicado 2018

Discovery through clinical sequencing in oncology

por Donoghue, Mark T.A., Schram, Alison M., Hyman, David M., Taylor, Barry S.
Publicado 2020

Basket Trials in Oncology: A Trade-Off Between Complexity and Efficiency

por Cunanan, Kristen M., Gonen, Mithat, Shen, Ronglai, Hyman, David M., Riely, Gregory J., Begg, Colin B., Iasonos, Alexia
Publicado 2017

Diffuse reduction of cerebral grey matter volumes in Erdheim-Chester disease

por Diamond, Eli L., Hatzoglou, Vaios, Patel, Sneha, Abdel-Wahab, Omar, Rampal, Raajit, Hyman, David M., Holodny, Andrei I., Raj, Ashish
Publicado 2016

A phase Ib dose-escalation and expansion study of the oral MEK inhibitor pimasertib and PI3K/MTOR inhibitor voxtalisib in patients with advanced solid tumours

por Schram, Alison M., Gandhi, Leena, Mita, Monica M., Damstrup, Lars, Campana, Frank, Hidalgo, Manuel, Grande, Enrique, Hyman, David M., Heist, Rebecca S.
Publicado 2018

Predictors of early treatment discontinuation in patients enrolled on Phase I oncology trials

por Hyman, David M., Eaton, Anne A., Gounder, Mrinal M., Pamer, Erika G., Pettiford, Jasmine, Carvajal, Richard D., Ivy, S. Percy, Iasonos, Alexia, Spriggs, David R.
Publicado 2015

Response to Selective RET Inhibition With LOXO-292 in a Patient With RET Fusion-Positive Lung Cancer With Leptomeningeal Metastases

por Guo, Robin, Schreyer, Mark, Chang, Jason C., Rothenberg, S. Michael, Henry, Dahlia, Cotzia, Paolo, Kris, Mark G., Rekhtman, Natasha, Young, Robert J., Hyman, David M., Drilon, Alexander
Publicado 2019

Larotrectinib Demonstrates CNS Efficacy in TRK Fusion-Positive Solid Tumors

por Rosen, Ezra Y., Schram, Alison M., Young, Robert J., Schreyer, Mark W., Hechtman, Jaclyn F., Shu, Catherine A., Ku, Nora C., Hyman, David M., Drilon, Alexander
Publicado 2019

Expression of the Carboxy-Terminal Portion of MUC16/CA125 Induces Transformation and Tumor Invasion

por Rao, Thapi D., Tian, Huasong, Ma, Xun, Yan, Xiujun, Thapi, Sahityasri, Schultz, Nikolaus, Rosales, Nestor, Monette, Sebastien, Wang, Amy, Hyman, David M., Levine, Douglas A., Solit, David, Spriggs, David R.
Publicado 2015

Larotrectinib versus Prior Therapies in Tropomyosin Receptor Kinase Fusion Cancer: An Intra-Patient Comparative Analysis

por Italiano, Antoine, Nanda, Shivani, Briggs, Andrew, Garcia-Foncillas, Jesus, Lassen, Ulrik, Vassal, Gilles, Kummar, Shivaani, van Tilburg, Cornelis M., Hong, David S., Laetsch, Theodore W., Keating, Karen, Reeves, John A., Fellous, Marc, Childs, Barrett H., Drilon, Alexander, Hyman, David M.
Publicado 2020

Efficacy of Vemurafenib in Patients With Non–Small-Cell Lung Cancer With BRAF V600 Mutation: An Open-Label, Single-Arm Cohort of the Histology-Independent VE-BASKET Study

por Subbiah, Vivek, Gervais, Radj, Riely, Gregory, Hollebecque, Antoine, Blay, Jean-Yves, Felip, Enriqueta, Schuler, Martin, Gonçalves, Anthony, Italiano, Antonio, Keedy, Vicki, Chau, Ian, Puzanov, Igor, Raje, Noopur S., Meric-Bernstam, Funda, Makrutzki, Martina, Riehl, Todd, Pitcher, Bethany, Baselga, Jose, Hyman, David M.
Publicado 2019

RAF inhibitor PLX8394 selectively disrupts BRAF-dimers and RAS-independent BRAF mutant-driven signaling

por Yao, Zhan, Gao, Yijun, Su, Wenjing, Yaeger, Rona, Tao, Jessica, Na, Na, Zhang, Ying, Zhang, Chao, Rymar, Andrey, Tao, Anthony, Timaul, Neilawattie M., Mcgriskin, Rory, Outmezguine, Nathaniel A., Zhao, HuiYong, Chang, Qing, Qeriqi, Besnik, Barbacid, Mariano, de Stanchina, Elisa, Hyman, David M, Bollag, Gideon, Rosen, Neal
Publicado 2018

Efficacy of MEK Inhibition in Patients with Histiocytic Neoplasms

por Diamond, Eli L., Durham, Benjamin H., Ulaner, Gary A, Drill, Esther, Buthorn, Justin, Ki, Michelle, Bitner, Lillian, Cho, Hana, Young, Robert J., Francis, Jasmine H, Rampal, Raajit, Lacouture, Mario, Brody, Lynn A., Ozkaya, Neval, Dogan, Ahmet, Rosen, Neal, Iasonos, Alexia, Abdel-Wahab, Omar, Hyman, David M.
Publicado 2019

Impact of race on dose selection of molecular-targeted agents in early-phase oncology trials

por Yokota, Tomoya, Bendell, Johanna, LoRusso, Patricia, Tsushima, Takahiro, Desai, Ved, Kenmotsu, Hirotsugu, Watanabe, Junichiro, Ono, Akira, Murugesan, Bhavani, Silva, Joseph, Naito, Tateaki, Greenberg, Jonathan, Kumar, Prasanna, Wang, Yibin, Jikoh, Takahiro, Shiga, Ryota, Hyman, David M., Ho, Alan Loh, Spriggs, David R., Schwartz, Gary K., Gounder, Mrinal M.
Publicado 2018

BRAF Inhibition in BRAF(V600)-Mutant Gliomas: Results From the VE-BASKET Study

por Kaley, Thomas, Touat, Mehdi, Subbiah, Vivek, Hollebecque, Antoine, Rodon, Jordi, Lockhart, A. Craig, Keedy, Vicki, Bielle, Franck, Hofheinz, Ralf-Dieter, Joly, Florence, Blay, Jean-Yves, Chau, Ian, Puzanov, Igor, Raje, Noopur S., Wolf, Jurgen, DeAngelis, Lisa M., Makrutzki, Martina, Riehl, Todd, Pitcher, Bethany, Baselga, Jose, Hyman, David M.
Publicado 2018

Early disease progression and treatment discontinuation in patients with advanced ovarian cancer receiving immune checkpoint blockade

por Boland, Julia L., Zhou, Qin, Martin, Madhuri, Callahan, Margaret K., Konner, Jason, O’Cearbhaill, Roisin E., Friedman, Claire F., Tew, William, Makker, Vicky, Grisham, Rachel N., Hensley, Martee L., Zecca, Nicholas, Iasonos, Alexia E., Snyder, Alexandra, Hyman, David M., Sabbatini, Paul, Aghajanian, Carol, Cadoo, Karen A., Zamarin, Dmitriy
Publicado 2018

Genome doubling shapes the evolution and prognosis of advanced cancers

por Bielski, Craig M., Zehir, Ahmet, Penson, Alexander V., Donoghue, Mark T.A., Chatila, Walid, Armenia, Joshua, Chang, Matthew T., Schram, Alison M., Jonsson, Philip, Bandlamudi, Chaitanya, Razavi, Pedram, Iyer, Gopa, Robson, Mark E., Stadler, Zsofia K., Schultz, Nikolaus, Baselga, Jose, Solit, David B., Hyman, David M., Berger, Michael F., Taylor, Barry S.
Publicado 2018