Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

por Cnop, Miriam, Toivonen, Sanna, Igoillo-Esteve, Mariana, Salpea, Paraskevi
Publicado 2017

Glucose-6-Phosphate Dehydrogenase of Trypanosomatids: Characterization, Target Validation, and Drug Discovery

por Gupta, Shreedhara, Igoillo-Esteve, Mariana, Michels, Paul A. M., Cordeiro, Artur T.
Publicado 2011

tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors

por Arroyo, Maria Nicol, Green, Jonathan Alex, Cnop, Miriam, Igoillo-Esteve, Mariana
Publicado 2021

Current Drug Repurposing Strategies for Rare Neurodegenerative Disorders

por Shah, Sweta, Dooms, Marc Marie, Amaral-Garcia, Sofia, Igoillo-Esteve, Mariana
Publicado 2021

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

por Cunha, Daniel A., Ladrière, Laurence, Ortis, Fernanda, Igoillo-Esteve, Mariana, Gurzov, Esteban N., Lupi, Roberto, Marchetti, Piero, Eizirik, Décio L., Cnop, Miriam
Publicado 2009

Ubiquitin Fold Modifier 1 (UFM1) and Its Target UFBP1 Protect Pancreatic Beta Cells from ER Stress-Induced Apoptosis

por Lemaire, Katleen, Moura, Rodrigo F., Granvik, Mikaela, Igoillo-Esteve, Mariana, Hohmeier, Hans E., Hendrickx, Nico, Newgard, Christopher B., Waelkens, Etienne, Cnop, Miriam, Schuit, Frans
Publicado 2011

Genetic and Chemical Evaluation of Trypanosoma brucei Oleate Desaturase as a Candidate Drug Target

por Alloatti, Andrés, Gupta, Shreedhara, Gualdrón-López, Melisa, Igoillo-Esteve, Mariana, Nguewa, Paul A., Deumer, Gladys, Wallemacq, Pierre, Altabe, Silvia G., Michels, Paul A. M., Uttaro, Antonio D.
Publicado 2010

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

por Lytrivi, Maria, Ghaddar, Kassem, Lopes, Miguel, Rosengren, Victoria, Piron, Anthony, Yi, Xiaoyan, Johansson, Henrik, Lehtiö, Janne, Igoillo-Esteve, Mariana, Cunha, Daniel A., Marselli, Lorella, Marchetti, Piero, Ortsäter, Henrik, Eizirik, Decio L., Cnop, Miriam
Publicado 2020

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis

por Alvelos, Maria Inês, Szymczak, Florian, Castela, Ângela, Marín-Cañas, Sandra, de Souza, Bianca Marmontel, Gkantounas, Ioannis, Colli, Maikel, Fantuzzi, Federica, Cosentino, Cristina, Igoillo-Esteve, Mariana, Marselli, Lorella, Marchetti, Piero, Cnop, Miriam, Eizirik, Décio L.
Publicado 2021

LncRNA ARGI Contributes to Virus‐Induced Pancreatic β Cell Inflammation Through Transcriptional Activation of IFN‐Stimulated Genes

por González‐Moro, Itziar, Garcia‐Etxebarria, Koldo, Mendoza, Luis Manuel, Fernández‐Jiménez, Nora, Mentxaka, Jon, Olazagoitia‐Garmendia, Ane, Arroyo, María Nicol, Sawatani, Toshiaki, Moreno‐Castro, Cristina, Vinci, Chiara, Op de Beek, Anne, Cnop, Miriam, Igoillo‐Esteve, Mariana, Santin, Izortze
Publicado 2023

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

por Abdulkarim, Baroj, Nicolino, Marc, Igoillo-Esteve, Mariana, Daures, Mathilde, Romero, Sophie, Philippi, Anne, Senée, Valérie, Lopes, Miguel, Cunha, Daniel A., Harding, Heather P., Derbois, Céline, Bendelac, Nathalie, Hattersley, Andrew T., Eizirik, Décio L., Ron, David, Cnop, Miriam, Julier, Cécile
Publicado 2015

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

por Volkmar, Michael, Dedeurwaerder, Sarah, Cunha, Daniel A, Ndlovu, Matladi N, Defrance, Matthieu, Deplus, Rachel, Calonne, Emilie, Volkmar, Ute, Igoillo-Esteve, Mariana, Naamane, Najib, Del Guerra, Silvia, Masini, Matilde, Bugliani, Marco, Marchetti, Piero, Cnop, Miriam, Eizirik, Decio L, Fuks, François
Publicado 2012

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

por Cunha, Daniel A., Igoillo-Esteve, Mariana, Gurzov, Esteban N., Germano, Carla M., Naamane, Najib, Marhfour, Ihsane, Fukaya, Makiko, Vanderwinden, Jean-Marie, Gysemans, Conny, Mathieu, Chantal, Marselli, Lorella, Marchetti, Piero, Harding, Heather P., Ron, David, Eizirik, Décio L., Cnop, Miriam
Publicado 2012

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

por Eizirik, Décio L., Sammeth, Michael, Bouckenooghe, Thomas, Bottu, Guy, Sisino, Giorgia, Igoillo-Esteve, Mariana, Ortis, Fernanda, Santin, Izortze, Colli, Maikel L., Barthson, Jenny, Bouwens, Luc, Hughes, Linda, Gregory, Lorna, Lunter, Gerton, Marselli, Lorella, Marchetti, Piero, McCarthy, Mark I., Cnop, Miriam
Publicado 2012

tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans

por Igoillo-Esteve, Mariana, Genin, Anne, Lambert, Nelle, Désir, Julie, Pirson, Isabelle, Abdulkarim, Baroj, Simonis, Nicolas, Drielsma, Anais, Marselli, Lorella, Marchetti, Piero, Vanderhaeghen, Pierre, Eizirik, Décio L., Wuyts, Wim, Julier, Cécile, Chakera, Ali J., Ellard, Sian, Hattersley, Andrew T., Abramowicz, Marc, Cnop, Miriam
Publicado 2013

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

por Fantuzzi, Federica, Toivonen, Sanna, Schiavo, Andrea Alex, Chae, Heeyoung, Tariq, Mohammad, Sawatani, Toshiaki, Pachera, Nathalie, Cai, Ying, Vinci, Chiara, Virgilio, Enrico, Ladriere, Laurence, Suleiman, Mara, Marchetti, Piero, Jonas, Jean-Christophe, Gilon, Patrick, Eizirik, Décio L., Igoillo-Esteve, Mariana, Cnop, Miriam
Publicado 2022

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

por Cosentino, Cristina, Toivonen, Sanna, Diaz Villamil, Esteban, Atta, Mohamed, Ravanat, Jean-Luc, Demine, Stéphane, Schiavo, Andrea Alex, Pachera, Nathalie, Deglasse, Jean-Philippe, Jonas, Jean-Christophe, Balboa, Diego, Otonkoski, Timo, Pearson, Ewan R, Marchetti, Piero, Eizirik, Décio L, Cnop, Miriam, Igoillo-Esteve, Mariana
Publicado 2018

GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models

por Gorgogietas, Vyron, Rajaei, Bahareh, Heeyoung, Chae, Santacreu, Bruno J., Marín-Cañas, Sandra, Salpea, Paraskevi, Sawatani, Toshiaki, Musuaya, Anyishai, Arroyo, María N., Moreno-Castro, Cristina, Benabdallah, Khadija, Demarez, Celine, Toivonen, Sanna, Cosentino, Cristina, Pachera, Nathalie, Lytrivi, Maria, Cai, Ying, Carnel, Lode, Brown, Cris, Urano, Fumihiko, Marchetti, Piero, Gilon, Patrick, Eizirik, Decio L., Cnop, Miriam, Igoillo-Esteve, Mariana
Publicado 2023

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress

por De Franco, Elisa, Lytrivi, Maria, Ibrahim, Hazem, Montaser, Hossam, Wakeling, Matthew N., Fantuzzi, Federica, Patel, Kashyap, Demarez, Céline, Cai, Ying, Igoillo-Esteve, Mariana, Cosentino, Cristina, Lithovius, Väinö, Vihinen, Helena, Jokitalo, Eija, Laver, Thomas W., Johnson, Matthew B., Sawatani, Toshiaki, Shakeri, Hadis, Pachera, Nathalie, Haliloglu, Belma, Ozbek, Mehmet Nuri, Unal, Edip, Yıldırım, Ruken, Godbole, Tushar, Yildiz, Melek, Aydin, Banu, Bilheu, Angeline, Suzuki, Ikuo, Flanagan, Sarah E., Vanderhaeghen, Pierre, Senée, Valérie, Julier, Cécile, Marchetti, Piero, Eizirik, Decio L., Ellard, Sian, Saarimäki-Vire, Jonna, Otonkoski, Timo, Cnop, Miriam, Hattersley, Andrew T.
Publicado 2020