Tau-tubulin kinase

por Ikezu, Seiko, Ikezu, Tsuneya
Publicado 2014

Neuritogenic function of microglia in maternal immune activation and autism spectrum disorders

por Kalavai, Srinidhi Venkatesan, Ikezu, Seiko
Publicado 2020

Microglial WNT5A supports dendritic spines maturation and neuronal firing

por Yeh, Hana, Woodbury, Maya E., Ingraham Dixie, Kaitlin L., Ikezu, Tsuneya, Ikezu, Seiko
Publicado 2023

Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

por Ikezu, Seiko, Ingraham Dixie, Kaitlin L., Koro, Lacin, Watanabe, Takashi, Kaibuchi, Kozo, Ikezu, Tsuneya
Publicado 2020

Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study

por Muraoka, Satoshi, Jedrychowski, Mark P., Yanamandra, Kiran, Ikezu, Seiko, Gygi, Steven P., Ikezu, Tsuneya
Publicado 2020

Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice

por Yukawa, Kayo, Yamamoto-Mcguire, Satomi, Cafaro, Louis, Hong, Christine, Kamme, Fredrik, Ikezu, Tsuneya, Ikezu, Seiko
Publicado 2023

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

por Ruan, Zhi, Delpech, Jean-Christophe, Venkatesan Kalavai, Srinidhi, Van Enoo, Alicia A., Hu, Jianqiao, Ikezu, Seiko, Ikezu, Tsuneya
Publicado 2020

Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia

por Ruan, Zhi, Takamatsu-Yukawa, Kayo, Wang, Yuzhi, Ushman, Margaret L., Labadorf, Adam Thomas, Ericsson, Maria, Ikezu, Seiko, Ikezu, Tsuneya
Publicado 2022

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

por Clayton, Kevin, Delpech, Jean Christophe, Herron, Shawn, Iwahara, Naotoshi, Ericsson, Maria, Saito, Takashi, Saido, Takaomi C., Ikezu, Seiko, Ikezu, Tsuneya
Publicado 2021

Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

por Clayton, Kevin, Delpech, Jean Christophe, Herron, Shawn, Iwahara, Naotoshi, Ericsson, Maria, Saito, Takashi, Saido, Takaomi C., Ikezu, Seiko, Ikezu, Tsuneya
Publicado 2021

Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles

por Muraoka, Satoshi, Lin, Weiwei, Takamatsu-Yukawa, Kayo, Hu, Jianqiao, Ikezu, Seiko, DeTure, Michael A, Dickson, Dennis W, Emili, Andrew, Ikezu, Tsuneya
Publicado 2021

Comprehensive characterization of human brain‐derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications

por Zhang, Zhengrong, Yu, Kaiwen, You, Yang, Jiang, Peizhou, Wu, Zhiping, DeTure, Michael A., Dickson, Dennis W., Ikezu, Seiko, Peng, Junmin, Ikezu, Tsuneya
Publicado 2023

Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy

por Muraoka, Satoshi, Jedrychowski, Mark P., Tatebe, Harutsugu, DeLeo, Annina M., Ikezu, Seiko, Tokuda, Takahiko, Gygi, Steven P., Stern, Robert A., Ikezu, Tsuneya
Publicado 2019

Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy

por Muraoka, Satoshi, DeLeo, Annina M, Yang, Zijian, Tatebe, Harutsugu, Yukawa-Takamatsu, Kayo, Ikezu, Seiko, Tokuda, Takahiko, Issadore, David, Stern, Robert A, Ikezu, Tsuneya
Publicado 2021

Alzheimer’s disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR‐edited human neuronal cells

por You, Yang, Hersh, Samuel W., Aslebagh, Roshanak, Shaffer, Scott A., Ikezu, Seiko, Mez, Jesse, Lunetta, Kathryn L., Logue, Mark W., Farrer, Lindsay A., Ikezu, Tsuneya
Publicado 2022

Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models

por Muraoka, Satoshi, Jedrychowski, Mark P., Iwahara, Naotoshi, Abdullah, Mohammad, Onos, Kristen D., Keezer, Kelly J., Hu, Jianqiao, Ikezu, Seiko, Howell, Gareth R., Gygi, Steven P., Ikezu, Tsuneya
Publicado 2021

Wolframin-1–expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice

por Delpech, Jean-Christophe, Pathak, Dhruba, Varghese, Merina, Kalavai, Srinidhi Venkatesan, Hays, Emma C., Hof, Patrick R., Johnson, W. Evan, Ikezu, Seiko, Medalla, Maria, Luebke, Jennifer I., Ikezu, Tsuneya
Publicado 2021

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

por Ruan, Zhi, Pathak, Dhruba, Venkatesan Kalavai, Srinidhi, Yoshii-Kitahara, Asuka, Muraoka, Satoshi, Bhatt, Nemil, Takamatsu-Yukawa, Kayo, Hu, Jianqiao, Wang, Yuzhi, Hersh, Samuel, Ericsson, Maria, Gorantla, Santhi, Gendelman, Howard E, Kayed, Rakez, Ikezu, Seiko, Luebke, Jennifer I, Ikezu, Tsuneya
Publicado 2020

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

por Muraoka, Satoshi, DeLeo, Annina M., Sethi, Manveen K., Yukawa‐Takamatsu, Kayo, Yang, Zijian, Ko, Jina, Hogan, John D., Ruan, Zhi, You, Yang, Wang, Yuzhi, Medalla, Maria, Ikezu, Seiko, Chen, Mei, Xia, Weiming, Gorantla, Santhi, Gendelman, Howard E., Issadore, David, Zaia, Joseph, Ikezu, Tsuneya
Publicado 2020

Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3(+) neurodegenerative microglia

por Shi, Haoshen, Yin, Zhuoran, Koronyo, Yosef, Fuchs, Dieu-Trang, Sheyn, Julia, Davis, Miyah R., Wilson, Jered W., Margeta, Milica A., Pitts, Kristen M., Herron, Shawn, Ikezu, Seiko, Ikezu, Tsuneya, Graham, Stuart L., Gupta, Vivek K., Black, Keith L., Mirzaei, Mehdi, Butovsky, Oleg, Koronyo-Hamaoui, Maya
Publicado 2022