Modeling neurodevelopment in a dish with pluripotent stem cells

por Imaizumi, Kent, Okano, Hideyuki
Publicado 2020

Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD

por Imaizumi, Kent, Ideno, Hirosato, Sato, Tsukika, Morimoto, Satoru, Okano, Hideyuki
Publicado 2022

Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons

por Watanabe, Hirotaka, Imaizumi, Kent, Cai, Tetsuo, Zhou, Zhi, Tomita, Taisuke, Okano, Hideyuki
Publicado 2021

Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes

por Imaizumi, Kent, Sone, Takefumi, Ibata, Keiji, Fujimori, Koki, Yuzaki, Michisuke, Akamatsu, Wado, Okano, Hideyuki
Publicado 2015

Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms

por Ideno, Hirosato, Imaizumi, Kent, Shimada, Hiroko, Sanosaka, Tsukasa, Nemoto, Akisa, Kohyama, Jun, Okano, Hideyuki
Publicado 2022

Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling

por Imaizumi, Kent, Fujimori, Koki, Ishii, Seiji, Otomo, Asako, Hosoi, Yasushi, Miyajima, Hiroaki, Warita, Hitoshi, Aoki, Masashi, Hadano, Shinji, Akamatsu, Wado, Okano, Hideyuki
Publicado 2018

Human Astrocytes Model Derived from Induced Pluripotent Stem Cells

por Leventoux, Nicolas, Morimoto, Satoru, Imaizumi, Kent, Sato, Yuta, Takahashi, Shinichi, Mashima, Kyoko, Ishikawa, Mitsuru, Sonn, Iki, Kondo, Takahiro, Watanabe, Hirotaka, Okano, Hideyuki
Publicado 2020

Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model

por Watanabe, Hirotaka, Murakami, Rei, Tsumagari, Kazuya, Morimoto, Satoru, Hashimoto, Tadafumi, Imaizumi, Kent, Sonn, Iki, Yamada, Kaoru, Saito, Yuko, Murayama, Shigeo, Iwatsubo, Takeshi, Okano, Hideyuki
Publicado 2023

The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy

por Nakamoto, Fumiko Kusunoki, Okamoto, Satoshi, Mitsui, Jun, Sone, Takefumi, Ishikawa, Mitsuru, Yamamoto, Yorihiro, Kanegae, Yumi, Nakatake, Yuhki, Imaizumi, Kent, Ishiura, Hiroyuki, Tsuji, Shoji, Okano, Hideyuki
Publicado 2018

Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells

por Kajikawa, Keita, Imaizumi, Kent, Shinozaki, Munehisa, Shibata, Shinsuke, Shindo, Tomoko, Kitagawa, Takahiro, Shibata, Reo, Kamata, Yasuhiro, Kojima, Kota, Nagoshi, Narihito, Matsumoto, Morio, Nakamura, Masaya, Okano, Hideyuki
Publicado 2020

Single‐cell study of neural stem cells derived from human iPSCs reveals distinct progenitor populations with neurogenic and gliogenic potential

por Lam, Matti, Sanosaka, Tsukasa, Lundin, Anders, Imaizumi, Kent, Etal, Damla, Karlsson, Fredrik H., Clausen, Maryam, Cairns, Jonathan, Hicks, Ryan, Kohyama, Jun, Kele, Malin, Okano, Hideyuki, Falk, Anna
Publicado 2019

Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment

por Meng, Xiangling, Yao, David, Imaizumi, Kent, Chen, Xiaoyu, Kelley, Kevin W., Reis, Noah, Thete, Mayuri Vijay, Arjun McKinney, Arpana, Kulkarni, Shravanti, Panagiotakos, Georgia, Bassik, Michael C., Pașca, Sergiu P.
Publicado 2023

A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer

por Shimada, Hiroko, Sato, Yuta, Sasaki, Takashi, Shimozawa, Aki, Imaizumi, Kent, Shindo, Tomoko, Miyao, Sachiyo, Kiyama, Kosuke, Kondo, Takahiro, Shibata, Shinsuke, Ishii, Seiji, Kuromitsu, Junro, Aoyagi, Hirofumi, Ito, Daisuke, Okano, Hideyuki
Publicado 2022

Gene therapy using genome‐edited iPS cells for targeting malignant glioma

por Tamura, Ryota, Miyoshi, Hiroyuki, Imaizumi, Kent, Yo, Masahiro, Kase, Yoshitaka, Sato, Tsukika, Sato, Mizuto, Morimoto, Yukina, Sampetrean, Oltea, Kohyama, Jun, Shinozaki, Munehisa, Miyawaki, Atsushi, Yoshida, Kazunari, Saya, Hideyuki, Okano, Hideyuki, Toda, Masahiro
Publicado 2022

Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury

por Kitagawa, Takahiro, Nagoshi, Narihito, Kamata, Yasuhiro, Kawai, Momotaro, Ago, Kentaro, Kajikawa, Keita, Shibata, Reo, Sato, Yuta, Imaizumi, Kent, Shindo, Tomoko, Shinozaki, Munehisa, Kohyama, Jun, Shibata, Shinsuke, Matsumoto, Morio, Nakamura, Masaya, Okano, Hideyuki
Publicado 2022

Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species

por Yoshimatsu, Sho, Nakajima, Mayutaka, Iguchi, Aozora, Sanosaka, Tsukasa, Sato, Tsukika, Nakamura, Mari, Nakajima, Ryusuke, Arai, Eri, Ishikawa, Mitsuru, Imaizumi, Kent, Watanabe, Hirotaka, Okahara, Junko, Noce, Toshiaki, Takeda, Yuta, Sasaki, Erika, Behr, Rüdiger, Edamura, Kazuya, Shiozawa, Seiji, Okano, Hideyuki
Publicado 2021

A non-invasive system to monitor in vivo neural graft activity after spinal cord injury

por Ago, Kentaro, Nagoshi, Narihito, Imaizumi, Kent, Kitagawa, Takahiro, Kawai, Momotaro, Kajikawa, Keita, Shibata, Reo, Kamata, Yasuhiro, Kojima, Kota, Shinozaki, Munehisa, Kondo, Takahiro, Iwano, Satoshi, Miyawaki, Atsushi, Ohtsuka, Masanari, Bito, Haruhiko, Kobayashi, Kenta, Shibata, Shinsuke, Shindo, Tomoko, Kohyama, Jun, Matsumoto, Morio, Nakamura, Masaya, Okano, Hideyuki
Publicado 2022

Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling

por Matsumoto, Takuya, Fujimori, Koki, Andoh-Noda, Tomoko, Ando, Takayuki, Kuzumaki, Naoko, Toyoshima, Manabu, Tada, Hirobumi, Imaizumi, Kent, Ishikawa, Mitsuru, Yamaguchi, Ryo, Isoda, Miho, Zhou, Zhi, Sato, Shigeto, Kobayashi, Tetsuro, Ohtaka, Manami, Nishimura, Ken, Kurosawa, Hiroshi, Yoshikawa, Takeo, Takahashi, Takuya, Nakanishi, Mahito, Ohyama, Manabu, Hattori, Nobutaka, Akamatsu, Wado, Okano, Hideyuki
Publicado 2016